25 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

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Your Input:
	ABCG1	ATP binding cassette subfamily G member 1. (666 aa)
	APOA5	Apolipoprotein A5. (370 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (901 aa)
	LIPC	Lipase C, hepatic type. (463 aa)
	PCSK4	Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (645 aa)
	APOB	Apolipoprotein B. (4482 aa)
	APOA2	Apolipoprotein A2. (101 aa)
	LMF2	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (684 aa)
	P4HB	Protein disulfide-isomerase. (509 aa)
	APOC3	Apolipoprotein C3. (130 aa)
	LMF1	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family. (556 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (794 aa)
	PDIA2	Protein disulfide isomerase family A member 2. (523 aa)
	ANGPTL8	Angiopoietin like 8. (198 aa)
	LPL	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (473 aa)
	APOA1	Apolipoprotein A1. (264 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (495 aa)
	ANGPTL3	Angiopoietin like 3. (455 aa)
	Pltp	BPI1 domain-containing protein. (147 aa)
	MTTP	Microsomal triglyceride transfer protein. (840 aa)
	ANGPTL4	Angiopoietin like 4. (421 aa)
	PCSK5	Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1880 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
	LIPG	Lipase G, endothelial type. (500 aa)
	LCAT	Lecithin-cholesterol acyltransferase. (440 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	APOA1	ENSSTOP00000016494	ENSSTOP00000002077	ATP binding cassette subfamily G member 1.	Apolipoprotein A1.	0.799
ABCG1	APOA2	ENSSTOP00000016494	ENSSTOP00000020847	ATP binding cassette subfamily G member 1.	Apolipoprotein A2.	0.451
ABCG1	Pltp	ENSSTOP00000016494	ENSSTOP00000004557	ATP binding cassette subfamily G member 1.	BPI1 domain-containing protein.	0.408
ANGPTL3	ANGPTL4	ENSSTOP00000004549	ENSSTOP00000007221	Angiopoietin like 3.	Angiopoietin like 4.	0.840
ANGPTL3	ANGPTL8	ENSSTOP00000004549	ENSSTOP00000023543	Angiopoietin like 3.	Angiopoietin like 8.	0.952
ANGPTL3	APOA1	ENSSTOP00000004549	ENSSTOP00000002077	Angiopoietin like 3.	Apolipoprotein A1.	0.434
ANGPTL3	APOA5	ENSSTOP00000004549	ENSSTOP00000017348	Angiopoietin like 3.	Apolipoprotein A5.	0.633
ANGPTL3	APOB	ENSSTOP00000004549	ENSSTOP00000020666	Angiopoietin like 3.	Apolipoprotein B.	0.576
ANGPTL3	APOC3	ENSSTOP00000004549	ENSSTOP00000022848	Angiopoietin like 3.	Apolipoprotein C3.	0.487
ANGPTL3	LIPC	ENSSTOP00000004549	ENSSTOP00000030828	Angiopoietin like 3.	Lipase C, hepatic type.	0.405
ANGPTL3	LIPG	ENSSTOP00000004549	ENSSTOP00000014330	Angiopoietin like 3.	Lipase G, endothelial type.	0.416
ANGPTL3	LMF1	ENSSTOP00000004549	ENSSTOP00000016272	Angiopoietin like 3.	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family.	0.437
ANGPTL3	LPL	ENSSTOP00000004549	ENSSTOP00000001322	Angiopoietin like 3.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.845
ANGPTL3	PLG	ENSSTOP00000004549	ENSSTOP00000023249	Angiopoietin like 3.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.539
ANGPTL4	ANGPTL3	ENSSTOP00000007221	ENSSTOP00000004549	Angiopoietin like 4.	Angiopoietin like 3.	0.840
ANGPTL4	ANGPTL8	ENSSTOP00000007221	ENSSTOP00000023543	Angiopoietin like 4.	Angiopoietin like 8.	0.931
ANGPTL4	LMF1	ENSSTOP00000007221	ENSSTOP00000016272	Angiopoietin like 4.	Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family.	0.400
ANGPTL4	LPL	ENSSTOP00000007221	ENSSTOP00000001322	Angiopoietin like 4.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.827
ANGPTL8	ANGPTL3	ENSSTOP00000023543	ENSSTOP00000004549	Angiopoietin like 8.	Angiopoietin like 3.	0.952
ANGPTL8	ANGPTL4	ENSSTOP00000023543	ENSSTOP00000007221	Angiopoietin like 8.	Angiopoietin like 4.	0.931