STRINGSTRING
SMAD7 SMAD7 IRX5 IRX5 LOC101976737 LOC101976737 SMAD4 SMAD4 ACVR2A ACVR2A PARD6A PARD6A LOC101959358 LOC101959358 BMP2 BMP2 PCSK4 PCSK4 LTBP3 LTBP3 IRX4 IRX4 NOG NOG GREM2 GREM2 LOC101966763 LOC101966763 LDLRAD4 LDLRAD4 INHBB INHBB NEDD8 NEDD8 LOC101970997 LOC101970997 MKX MKX ITGAV ITGAV RBL1 RBL1 MEIS3 MEIS3 TGFB3 TGFB3 UBE2M UBE2M ZCCHC4 ZCCHC4 GDF2 GDF2 CCNT1 CCNT1 NCOR2 NCOR2 TGFBR2 TGFBR2 LOC101955706 LOC101955706 JUNB JUNB SMURF2 SMURF2 TRIM33 TRIM33 LTBP2 LTBP2 ENSSTOP00000026639 ENSSTOP00000026639 DRAP1 DRAP1 TFDP2 TFDP2 MEN1 MEN1 NCOR1 NCOR1 CCNK CCNK ENSSTOP00000028703 ENSSTOP00000028703 ZFYVE9 ZFYVE9 MTMR4 MTMR4 Inhba Inhba F11R F11R LOC101961455 LOC101961455 SKI SKI ENSSTOP00000031366 ENSSTOP00000031366 ACVR1C ACVR1C IRX1 IRX1 CHRDL2 CHRDL2 ACVRL1 ACVRL1 ACVR1B ACVR1B SMAD6 SMAD6 USP9X USP9X MAPK3 MAPK3 STRAP STRAP TGFB2 TGFB2 RNF111 RNF111 FSTL1 FSTL1 PMEPA1 PMEPA1 TGIF2 TGIF2 ATP1B4 ATP1B4 BMPR2 BMPR2 TFDP1 TFDP1 Itgb3 Itgb3 SNW1 SNW1 IRX2 IRX2 AMHR2 AMHR2 SMAD2 SMAD2 Cgn Cgn Rhoa Rhoa UBA52 UBA52 ACVR1 ACVR1 CHRDL1 CHRDL1 CBL CBL SP1 SP1 SMAD9 SMAD9 UBE2D1 UBE2D1 ITGA8 ITGA8 FBN1 FBN1 ITGB5 ITGB5 SKIL SKIL CCNQ CCNQ ITGB6 ITGB6 CDK9 CDK9 FSTL3 FSTL3 Rps27a Rps27a LOC101963830 LOC101963830 TGFB1 TGFB1 FOXH1 FOXH1 PARD3B PARD3B SMAD3 SMAD3 BMP10 BMP10 CCNT2 CCNT2 SMAD1 SMAD1 LTBP1 LTBP1 SMAD5 SMAD5 Hdac1 Hdac1 I3MJJ6_ICTTR I3MJJ6_ICTTR NEDD4L NEDD4L FST FST E2F5 E2F5 ITGB1 ITGB1 TGFBR1 TGFBR1 LTBP4 LTBP4 PPM1A PPM1A MAPK1 MAPK1 FURIN FURIN ACVR2B ACVR2B BAMBI BAMBI IRX6 IRX6 BMPR1B BMPR1B PARD3 PARD3 SMURF1 SMURF1 BMPR1A BMPR1A PARP1 PARP1 ITGB8 ITGB8 E2F4 E2F4 CCNC CCNC Cdk8 Cdk8 TGIF1 TGIF1 IRX3 IRX3 STUB1 STUB1 AMH AMH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD7Mothers against decapentaplegic homolog. (426 aa)
IRX5Iroquois homeobox 5. (424 aa)
LOC101976737FYVE-type domain-containing protein. (1544 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
PARD6APar-6 family cell polarity regulator alpha. (345 aa)
LOC101959358Uncharacterized protein. (193 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (645 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1193 aa)
IRX4Iroquois homeobox 4. (420 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GREM2Gremlin. (168 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
INHBBInhibin subunit beta B. (336 aa)
NEDD8NEDD8 ubiquitin like modifier. (81 aa)
LOC101970997Protein kinase domain-containing protein. (337 aa)
MKXMohawk homeobox. (352 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1077 aa)
RBL1RB transcriptional corepressor like 1. (1038 aa)
MEIS3Meis homeobox 3. (378 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (513 aa)
GDF2Growth differentiation factor 2. (429 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (726 aa)
NCOR2Nuclear receptor corepressor 2. (2447 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101955706Peptidylprolyl isomerase. (108 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SMURF2E3 ubiquitin-protein ligase. (740 aa)
TRIM33Tripartite motif containing 33. (1028 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1813 aa)
ENSSTOP00000026639Hist_deacetyl domain-containing protein. (323 aa)
DRAP1DR1 associated protein 1. (141 aa)
TFDP2Transcription factor. (446 aa)
MEN1Menin 1. (616 aa)
NCOR1Nuclear receptor corepressor 1. (2529 aa)
CCNKCyclin K; Belongs to the cyclin family. (582 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1425 aa)
MTMR4Myotubularin related protein 4. (1208 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
F11RF11 receptor. (298 aa)
LOC101961455Uncharacterized protein. (334 aa)
SKISKI proto-oncogene. (730 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
IRX1Iroquois homeobox 1. (457 aa)
CHRDL2Chordin like 2. (424 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RNF111Ring finger protein 111. (984 aa)
FSTL1Follistatin like 1. (310 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (264 aa)
TGIF2TGFB induced factor homeobox 2. (237 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
TFDP1Transcription factor. (410 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
SNW1SNW domain containing 1. (554 aa)
IRX2Iroquois homeobox 2. (446 aa)
AMHR2Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. (550 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CgnMyosin_tail_1 domain-containing protein. (1195 aa)
RhoaRas homolog family member A. (193 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CHRDL1Chordin like 1. (447 aa)
CBLCbl proto-oncogene. (870 aa)
SP1Sp1 transcription factor. (788 aa)
SMAD9Mothers against decapentaplegic homolog. (452 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1066 aa)
FBN1Fibrillin 1. (2736 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SKILSKI like proto-oncogene. (677 aa)
CCNQCyclin Q; Belongs to the cyclin family. (250 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (786 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
FSTL3Follistatin like 3. (261 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
LOC101963830Uncharacterized protein. (1013 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
FOXH1Forkhead box H1. (370 aa)
PARD3BPar-3 family cell polarity regulator beta. (1204 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP10Bone morphogenetic protein 10. (422 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (728 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1488 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
Hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (399 aa)
I3MJJ6_ICTTRPeptidylprolyl isomerase. (98 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (962 aa)
FSTFollistatin. (330 aa)
E2F5E2F transcription factor 5. (315 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1598 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
IRX6Iroquois homeobox 6. (436 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PARD3Par-3 family cell polarity regulator. (1296 aa)
SMURF1E3 ubiquitin-protein ligase. (753 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
E2F4E2F transcription factor 4. (406 aa)
CCNCCyclin C; Belongs to the cyclin family. (246 aa)
Cdk8Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
TGIF1TGFB induced factor homeobox 1. (272 aa)
IRX3Iroquois homeobox 3. (443 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
AMHAnti-Mullerian hormone. (545 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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