STRINGSTRING
UBE2V1 UBE2V1 LOC106144935 LOC106144935 MAPK7 MAPK7 TRAF3 TRAF3 MAPK3 MAPK3 PPP4R4 PPP4R4 PPP2R1A PPP2R1A LOC101954381 LOC101954381 MAPK10 MAPK10 I3LZW4_ICTTR I3LZW4_ICTTR NFKB2 NFKB2 TAB1 TAB1 FOS FOS UBA52 UBA52 RPS6KA2 RPS6KA2 IRF7 IRF7 IKBKB IKBKB NKIRAS2 NKIRAS2 N4BP1 N4BP1 DUSP6 DUSP6 MAPKAPK2 MAPKAPK2 USP14 USP14 Atf7 Atf7 LOC101966186 LOC101966186 UBE2D1 UBE2D1 TRAF6 TRAF6 LRRC45 LRRC45 NFKBIA NFKBIA LRRC74A LRRC74A TANK TANK TBK1 TBK1 Map3k20 Map3k20 Rps27a Rps27a MAP2K3 MAP2K3 DUSP4 DUSP4 NLRC5 NLRC5 ELK1 ELK1 I3MEP9_ICTTR I3MEP9_ICTTR Lrrc14 Lrrc14 RPS6KA3 RPS6KA3 NKIRAS1 NKIRAS1 PPP2CA PPP2CA LRRC71 LRRC71 ATF1 ATF1 CASP8 CASP8 NFKB1 NFKB1 TRAF2 TRAF2 MAPK8 MAPK8 NLRP12 NLRP12 Dusp3 Dusp3 IRAK2 IRAK2 ATF2 ATF2 FNBP4 FNBP4 MAPK1 MAPK1 RIPK2 RIPK2 MAPK11 MAPK11 LRRC34 LRRC34 LRRC31 LRRC31 CHUK CHUK CREB1 CREB1 Naip Naip TAB2 TAB2 RELCH RELCH PPP4R1 PPP4R1 NOD1 NOD1 NOD2 NOD2 VWC2 VWC2 CD14 CD14 RELA RELA LRRC74B LRRC74B MAPK15 MAPK15 TLR4 TLR4 MAP2K4 MAP2K4 IRF3 IRF3 NFKBIB NFKBIB LOC101966763 LOC101966763 CCDC71L CCDC71L PTPN11 PTPN11 PPP2R5D PPP2R5D TICAM2 TICAM2 FOSL2 FOSL2 ALPK1 ALPK1 MAP3K7 MAP3K7 ENSSTOP00000032279 ENSSTOP00000032279 RPS6KA1 RPS6KA1 ENSSTOP00000031366 ENSSTOP00000031366 MAPK9 MAPK9 MAP2K7 MAP2K7 NLRX1 NLRX1 BIRC7 BIRC7 MAPKAPK3 MAPKAPK3 ENSSTOP00000029566 ENSSTOP00000029566 TAB3 TAB3 RPS6KA5 RPS6KA5 ENSSTOP00000028911 ENSSTOP00000028911 ENSSTOP00000028703 ENSSTOP00000028703 ENSSTOP00000028611 ENSSTOP00000028611 LOC101954990 LOC101954990 UBE2D2 UBE2D2 VRK3 VRK3 CASP10 CASP10 JUN JUN KHNYN KHNYN S100A12 S100A12 TIFA TIFA MAPK14 MAPK14 LOC101970926 LOC101970926 Usp18 Usp18 SARM1 SARM1 Ikbke Ikbke IRAK1 IRAK1 AGER AGER TRAF5 TRAF5 ENSSTOP00000026616 ENSSTOP00000026616 PPP2R1B PPP2R1B NLRP6 NLRP6 APP APP CREB5 CREB5 IKBKG IKBKG Hmgb1 Hmgb1 ENSSTOP00000027318 ENSSTOP00000027318 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UBE2V1Ubiquitin conjugating enzyme E2 V1. (139 aa)
LOC106144935Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (100 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (812 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (835 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
LOC101954381UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
I3LZW4_ICTTRUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (129 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
IRF7Interferon regulatory factor 7. (472 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
NKIRAS2Uncharacterized protein. (191 aa)
N4BP1NEDD4 binding protein 1. (827 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (500 aa)
Atf7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (483 aa)
LOC101966186Uncharacterized protein. (159 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LRRC74ALeucine rich repeat containing 74A. (463 aa)
TANKTRAF family member associated NFKB activator. (439 aa)
TBK1TANK binding kinase 1. (729 aa)
Map3k20Uncharacterized protein. (800 aa)
Rps27aUbiquitin-like domain-containing protein. (156 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
NLRC5NLR family CARD domain containing 5. (1847 aa)
ELK1ETS transcription factor ELK1. (428 aa)
I3MEP9_ICTTRUncharacterized protein. (396 aa)
Lrrc14Uncharacterized protein. (214 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LRRC71Leucine rich repeat containing 71. (507 aa)
ATF1Activating transcription factor 1. (269 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
NLRP12NLR family pyrin domain containing 12. (975 aa)
Dusp3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (616 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
FNBP4Formin binding protein 4. (1071 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
LRRC34Leucine rich repeat containing 34. (459 aa)
LRRC31Leucine rich repeat containing 31. (494 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
NaipNACHT domain-containing protein. (1405 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (934 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (951 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LRRC74BLeucine rich repeat containing 74B. (397 aa)
MAPK15Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (554 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
IRF3Interferon regulatory factor 3. (420 aa)
NFKBIBNFKB inhibitor beta. (359 aa)
LOC101966763Ubiquitin-like domain-containing protein. (156 aa)
CCDC71LUncharacterized protein. (176 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
ALPK1Alpha kinase 1. (1226 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ENSSTOP00000032279Uncharacterized protein. (137 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
ENSSTOP00000031366Ubiquitin-like domain-containing protein. (95 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
NLRX1NLR family member X1. (975 aa)
BIRC7Baculoviral IAP repeat containing 7. (304 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
ENSSTOP00000029566UBIQUITIN_CONJUGAT_2 domain-containing protein. (122 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
RPS6KA5Ribosomal protein S6 kinase. (859 aa)
ENSSTOP00000028911UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
ENSSTOP00000028703Ubiquitin-like domain-containing protein. (122 aa)
ENSSTOP00000028611Uncharacterized protein. (195 aa)
LOC101954990Tyrosine-protein phosphatase domain-containing protein. (231 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (143 aa)
VRK3VRK serine/threonine kinase 3. (453 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
KHNYNKH and NYN domain containing. (669 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
TIFATRAF interacting protein with forkhead associated domain. (184 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC101970926Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
Usp18USP domain-containing protein; Belongs to the peptidase C19 family. (354 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENSSTOP00000026616Uncharacterized protein. (174 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
NLRP6NLR family pyrin domain containing 6. (880 aa)
APPAmyloid beta precursor protein. (739 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
Hmgb1Uncharacterized protein. (188 aa)
ENSSTOP00000027318BZIP domain-containing protein. (133 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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