16 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC101966763	Ubiquitin-like domain-containing protein. (156 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
	UBA52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (232 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
	Map3k20	Uncharacterized protein. (800 aa)
	Rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (616 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
	TLR4	Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
	ENSSTOP00000031366	Ubiquitin-like domain-containing protein. (95 aa)
	TICAM2	Toll like receptor adaptor molecule 2. (235 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (724 aa)
	ENSSTOP00000028703	Ubiquitin-like domain-containing protein. (122 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD14	IRAK2	ENSSTOP00000016628	ENSSTOP00000012537	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Interleukin 1 receptor associated kinase 2.	0.404
CD14	MAP3K7	ENSSTOP00000016628	ENSSTOP00000032393	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.486
CD14	Map3k20	ENSSTOP00000016628	ENSSTOP00000008071	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Uncharacterized protein.	0.426
CD14	TLR4	ENSSTOP00000016628	ENSSTOP00000017653	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll like receptor 4; Belongs to the Toll-like receptor family.	0.969
CD14	TRAF6	ENSSTOP00000016628	ENSSTOP00000006521	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.523
ENSSTOP00000028703	ENSSTOP00000031366	ENSSTOP00000028703	ENSSTOP00000031366	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.985
ENSSTOP00000028703	IRAK2	ENSSTOP00000028703	ENSSTOP00000012537	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 2.	0.626
ENSSTOP00000028703	LOC101966763	ENSSTOP00000028703	ENSSTOP00000019666	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.985
ENSSTOP00000028703	MAP3K7	ENSSTOP00000028703	ENSSTOP00000032393	Ubiquitin-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.682
ENSSTOP00000028703	Map3k20	ENSSTOP00000028703	ENSSTOP00000008071	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.669
ENSSTOP00000028703	Rps27a	ENSSTOP00000028703	ENSSTOP00000008580	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.985
ENSSTOP00000028703	TAB2	ENSSTOP00000028703	ENSSTOP00000015218	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.915
ENSSTOP00000028703	TAB3	ENSSTOP00000028703	ENSSTOP00000029490	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.819
ENSSTOP00000028703	TRAF6	ENSSTOP00000028703	ENSSTOP00000006521	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.966
ENSSTOP00000031366	ENSSTOP00000028703	ENSSTOP00000031366	ENSSTOP00000028703	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.985
ENSSTOP00000031366	IRAK2	ENSSTOP00000031366	ENSSTOP00000012537	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 2.	0.622
ENSSTOP00000031366	MAP3K7	ENSSTOP00000031366	ENSSTOP00000032393	Ubiquitin-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.675
ENSSTOP00000031366	Map3k20	ENSSTOP00000031366	ENSSTOP00000008071	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.637
ENSSTOP00000031366	TAB1	ENSSTOP00000031366	ENSSTOP00000002106	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 1.	0.609
ENSSTOP00000031366	TAB2	ENSSTOP00000031366	ENSSTOP00000015218	Ubiquitin-like domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.932