STRINGSTRING
PLIN2 PLIN2 PRKAR2B PRKAR2B MEF2D MEF2D ADCY8 ADCY8 ASIC1 ASIC1 PRDM16 PRDM16 CGNL1 CGNL1 Adrb3 Adrb3 Clasp2 Clasp2 ADCY7 ADCY7 ACO2 ACO2 CUBN CUBN CIDEA CIDEA ASS1 ASS1 OTOF OTOF REEP6 REEP6 PPARGC1A PPARGC1A PNPLA2 PNPLA2 CD36 CD36 Gk Gk ADRA2A ADRA2A PLCB4 PLCB4 GJB1 GJB1 ADORA1 ADORA1 CIB2 CIB2 NFIL3 NFIL3 PLIN5 PLIN5 HADHA HADHA CLIC5 CLIC5 MGLL MGLL NPR1 NPR1 ACAA2 ACAA2 FCN1 FCN1 CCDC80 CCDC80 ADRB1 ADRB1 GSTM2 GSTM2 PLIN1 PLIN1 Asl Asl IGFBP5 IGFBP5 FGF21 FGF21 Myo5b Myo5b EGR1 EGR1 NR4A1 NR4A1 REEP4 REEP4 CPT2 CPT2 CALM1 CALM1 GNAI2 GNAI2 PDE3B PDE3B PDE8A PDE8A PCK1 PCK1 TECTB TECTB CPT1A CPT1A KMO KMO ASIC4 ASIC4 GNAI1 GNAI1 DGAT2 DGAT2 PYGL PYGL PLCG1 PLCG1 Lipe Lipe SCGB1A1 SCGB1A1 PLCD3 PLCD3 ACSL1 ACSL1 GNAI3 GNAI3 Fabp4 Fabp4 Eef1a1 Eef1a1 ATP4A ATP4A ATF3 ATF3 Aqp7 Aqp7 ADCY3 ADCY3 UBR5 UBR5 NNAT NNAT ADCY9 ADCY9 UCP3 UCP3 ADCY2 ADCY2 NR4A3 NR4A3 ADCY6 ADCY6 Fabp3 Fabp3 Sik1 Sik1 ALDH1A1 ALDH1A1 ADCY10 ADCY10 UCP1 UCP1 NR4A2 NR4A2 ADCY4 ADCY4 PNLIP PNLIP ABHD5 ABHD5 USH1C USH1C HADHB HADHB HADH HADH PLA2G4C PLA2G4C ZIC1 ZIC1 BHLHE40 BHLHE40 PLCL2 PLCL2 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLIN2Perilipin; Belongs to the perilipin family. (443 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (417 aa)
MEF2DMyocyte enhancer factor 2D. (524 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (538 aa)
PRDM16PR/SET domain 16. (1127 aa)
CGNL1Cingulin like 1. (1298 aa)
Adrb3G_PROTEIN_RECEP_F1_2 domain-containing protein. (404 aa)
Clasp2Uncharacterized protein. (1342 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
CUBNCubilin. (3522 aa)
CIDEACell death inducing DFFA like effector a. (171 aa)
ASS1Argininosuccinate synthase 1. (412 aa)
OTOFOtoferlin. (1995 aa)
REEP6Receptor expression-enhancing protein. (211 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
PNPLA2Patatin like phospholipase domain containing 2. (489 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
GkUncharacterized protein; Belongs to the FGGY kinase family. (559 aa)
ADRA2AAdrenoceptor alpha 2A; Belongs to the G-protein coupled receptor 1 family. (324 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
GJB1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (283 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
CIB2Calcium and integrin binding family member 2. (187 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (463 aa)
PLIN5Perilipin; Belongs to the perilipin family. (448 aa)
HADHAHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (791 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
MGLLMonoglyceride lipase. (311 aa)
NPR1Guanylate cyclase. (1037 aa)
ACAA2Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
FCN1Ficolin 1. (336 aa)
CCDC80Coiled-coil domain containing 80. (955 aa)
ADRB1Adrenoceptor beta 1. (418 aa)
GSTM2Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
PLIN1Perilipin; Belongs to the perilipin family. (517 aa)
AslUncharacterized protein. (464 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
Myo5bUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1814 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (598 aa)
REEP4Receptor expression-enhancing protein. (257 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (645 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PDE3BPhosphodiesterase. (1046 aa)
PDE8APhosphodiesterase. (766 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
TECTBTectorin beta. (339 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (465 aa)
ASIC4Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (539 aa)
GNAI1G protein subunit alpha i1. (354 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
LipeHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
SCGB1A1Secretoglobin family 1A member 1. (93 aa)
PLCD3Phosphoinositide phospholipase C. (782 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (698 aa)
GNAI3G protein subunit alpha i3. (354 aa)
Fabp4Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). FABPs are important elements related to the hibernating state in mammals. (132 aa)
Eef1a1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
ATP4AATPase H+/K+ transporting subunit alpha; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (924 aa)
ATF3Activating transcription factor 3. (181 aa)
Aqp7Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (223 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2782 aa)
NNATNeuronatin. (81 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (630 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
Fabp3Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABPs are important elements related to the hibernating state in mammals; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
Sik1Uncharacterized protein. (776 aa)
ALDH1A1Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
ADCY10Adenylate cyclase 10. (1610 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PNLIPPancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity). Plays a role in hibernation as a key enzyme that shows high activity at low temperatures. When expressed in the hibernating heart it liberates fatty acids from triglycerides at temperatures as low as 0 degrees Celsius. (465 aa)
ABHD5Abhydrolase domain containing 5. (349 aa)
USH1CUSH1 protein network component harmonin. (881 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
HADHHydroxyacyl-CoA dehydrogenase. (314 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
ZIC1Zic family member 1. (447 aa)
BHLHE40Basic helix-loop-helix family member e40. (411 aa)
PLCL2Phosphoinositide phospholipase C. (1100 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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