STRINGSTRING
Rbm3 Rbm3 ANXA9 ANXA9 ANXA6 ANXA6 IL13 IL13 FGF23 FGF23 BDNF BDNF ANXA7 ANXA7 PPARG PPARG AQP4 AQP4 ATF2 ATF2 IFNG IFNG ANXA5 ANXA5 BCL2 BCL2 FGF21 FGF21 Ins Ins CD34 CD34 CIRBP CIRBP RUNX2 RUNX2 Anxa2 Anxa2 ATF4 ATF4 METRNL METRNL FGF19 FGF19 ANXA3 ANXA3 ANXA1 ANXA1 SHBG SHBG APAF1 APAF1 KL KL ANXA11 ANXA11 STAT3 STAT3 IL10 IL10 Casp3 Casp3 UCP1 UCP1 LOC101956281 LOC101956281 ANXA13 ANXA13 ANXA4 ANXA4 Rtn3 Rtn3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rbm3RRM domain-containing protein. (156 aa)
ANXA9Annexin. (345 aa)
ANXA6Annexin. (673 aa)
IL13Interleukin 13. (130 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (252 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
ANXA7Annexin. (463 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (316 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
ANXA5Annexin. (321 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
CD34CD34 molecule. (382 aa)
CIRBPCold inducible RNA binding protein. (204 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (520 aa)
Anxa2Annexin. (339 aa)
ATF4Activating transcription factor 4. (352 aa)
METRNLMeteorin like, glial cell differentiation regulator. (280 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
ANXA3Annexin. (323 aa)
ANXA1Annexin. (346 aa)
SHBGSex hormone binding globulin. (405 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1247 aa)
KLKlotho. (1008 aa)
ANXA11Annexin. (503 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
IL10Interleukin 10. (178 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
LOC101956281Annexin. (329 aa)
ANXA13Annexin. (325 aa)
ANXA4Annexin. (319 aa)
Rtn3Reticulon. (255 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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