(13 nodes) (2022) Physiological Changes in Subjects Exposed to Accidental Hypothermia: An Update. network (Ictidomys tridecemlineatus)

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Your Input:
	GOT1	Aspartate aminotransferase. (413 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	VWF	Von Willebrand factor. (2819 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
	Prl	Uncharacterized protein. (227 aa)
	NOS1	Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (311 aa)
	TRH	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (240 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (266 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
	IL10	Interleukin 10. (178 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GOT1	IL10	ENSSTOP00000006725	ENSSTOP00000005716	Aspartate aminotransferase.	Interleukin 10.	0.412
GOT1	IL1B	ENSSTOP00000006725	ENSSTOP00000002047	Aspartate aminotransferase.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.412
IL10	GOT1	ENSSTOP00000005716	ENSSTOP00000006725	Interleukin 10.	Aspartate aminotransferase.	0.412
IL10	IL1B	ENSSTOP00000005716	ENSSTOP00000002047	Interleukin 10.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.863
IL10	NOS2	ENSSTOP00000005716	ENSSTOP00000017090	Interleukin 10.	Nitric oxide synthase; Produces nitric oxide (NO).	0.418
IL1B	GOT1	ENSSTOP00000002047	ENSSTOP00000006725	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Aspartate aminotransferase.	0.412
IL1B	IL10	ENSSTOP00000002047	ENSSTOP00000005716	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 10.	0.863
IL1B	MB	ENSSTOP00000002047	ENSSTOP00000005021	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.408
IL1B	NOS2	ENSSTOP00000002047	ENSSTOP00000017090	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Nitric oxide synthase; Produces nitric oxide (NO).	0.470
MB	IL1B	ENSSTOP00000005021	ENSSTOP00000002047	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.408
NOS1	NOS2	ENSSTOP00000023214	ENSSTOP00000017090	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.879
NOS1	NOS3	ENSSTOP00000023214	ENSSTOP00000030723	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.845
NOS1	TRH	ENSSTOP00000023214	ENSSTOP00000022079	Nitric oxide synthase; Produces nitric oxide (NO).	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.408
NOS2	IL10	ENSSTOP00000017090	ENSSTOP00000005716	Nitric oxide synthase; Produces nitric oxide (NO).	Interleukin 10.	0.418
NOS2	IL1B	ENSSTOP00000017090	ENSSTOP00000002047	Nitric oxide synthase; Produces nitric oxide (NO).	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.470
NOS2	NOS1	ENSSTOP00000017090	ENSSTOP00000023214	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.879
NOS2	NOS3	ENSSTOP00000017090	ENSSTOP00000030723	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.861
NOS3	NOS1	ENSSTOP00000030723	ENSSTOP00000023214	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.845
NOS3	NOS2	ENSSTOP00000030723	ENSSTOP00000017090	Nitric oxide synthase; Produces nitric oxide (NO).	Nitric oxide synthase; Produces nitric oxide (NO).	0.861
Prl	TRH	ENSSTOP00000024518	ENSSTOP00000022079	Uncharacterized protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.757