(116 nodes) Amino sugar and nucleotide sugar metabolism network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (649 aa)
	OXNAD1	Oxidoreductase NAD binding domain containing 1. (312 aa)
	GLT8D1	Glycosyltransferase 8 domain containing 1. (371 aa)
	HKDC1	Hexokinase domain containing 1. (917 aa)
	LARP4B	La ribonucleoprotein domain family member 4B. (721 aa)
	Ubash3a	Uncharacterized protein. (111 aa)
	NIPAL2	NIPA like domain containing 2. (338 aa)
	UGP2	UTP--glucose-1-phosphate uridylyltransferase. (506 aa)
	UAP1	UDP-N-acetylglucosamine pyrophosphorylase 1. (521 aa)
	M1AP	Meiosis 1 associated protein. (552 aa)
	GLT8D2	Glycosyltransferase 8 domain containing 2. (351 aa)
	METTL23	Methyltransferase like 23. (190 aa)
	NIPAL4	NIPA like domain containing 4. (394 aa)
	NANP	N-acetylneuraminic acid phosphatase. (248 aa)
	UGDH	UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
	Fam149b1	DUF3719 domain-containing protein. (298 aa)
	SLC25A23	Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (515 aa)
	HK2	Hexokinase 2. (917 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
	GCK	Phosphotransferase. (467 aa)
	GFPT2	Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
	NIPAL3	NIPA like domain containing 3. (406 aa)
	LARP4	La ribonucleoprotein domain family member 4. (724 aa)
	GLIPR1	GLI pathogenesis related 1; Belongs to the CRISP family. (265 aa)
	NAGK	N-acetylglucosamine kinase. (361 aa)
	Nipa2	Uncharacterized protein. (360 aa)
	NIPA1	NIPA magnesium transporter 1. (308 aa)
	HK3	Hexokinase 3. (867 aa)
	UHMK1	U2AF homology motif kinase 1. (419 aa)
	SYP	Synaptophysin. (313 aa)
	GCKR	Glucokinase regulator. (606 aa)
	CHIA	Chitinase acidic; Belongs to the glycosyl hydrolase 18 family. (306 aa)
	SYNPR	Synaptoporin. (285 aa)
	METTL21C	Methyltransferase like 21C. (263 aa)
	LOC101967703	Uncharacterized protein. (236 aa)
	NANS	N-acetylneuraminate synthase. (359 aa)
	PMM2	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (246 aa)
	FCSK	Fucose kinase. (1079 aa)
	HEXB	Beta-hexosaminidase. (538 aa)
	PGM2	Phosphoglucomutase 2. (617 aa)
	PGM5	Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
	CYB5R4	Cytochrome b5 reductase 4. (533 aa)
	HAS1	Hyaluronan synthase 1. (539 aa)
	Fam149a	DUF3719 domain-containing protein. (800 aa)
	NAA10	N(alpha)-acetyltransferase 10, NatA catalytic subunit. (235 aa)
	RENBP	Renin binding protein. (427 aa)
	CMAS	Cytidine monophosphate N-acetylneuraminic acid synthetase. (433 aa)
	NIPAL1	NIPA like domain containing 1. (416 aa)
	UAP1L1	UDP-N-acetylglucosamine pyrophosphorylase 1 like 1. (507 aa)
	SYPL2	Synaptophysin like 2. (266 aa)
	LOC101970692	Rieske domain-containing protein. (846 aa)
	CRISP2	Cysteine rich secretory protein 2; Belongs to the CRISP family. (255 aa)
	PI15	Peptidase inhibitor 15; Belongs to the CRISP family. (258 aa)
	GALK1	Galactokinase 1. (392 aa)
	Amdhd2	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. (409 aa)
	NFU1	NFU1 iron-sulfur cluster scaffold. (254 aa)
	GMPPB	GDP-mannose pyrophosphorylase B. (360 aa)
	GNPNAT1	Glucosamine 6-phosphate N-acetyltransferase. (184 aa)
	CHIT1	Chitinase 1; Belongs to the glycosyl hydrolase 18 family. (469 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	CHI3L1	Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (382 aa)
	UXS1	UDP-glucuronate decarboxylase 1. (421 aa)
	METTL21A	Methyltransferase like 21A. (218 aa)
	Gnpda1	Glucosamine-6-phosphate isomerase. (289 aa)
	HAS3	Hyaluronan synthase 3. (553 aa)
	SLC25A24	Solute carrier family 25 member 24; Belongs to the mitochondrial carrier (TC 2.A.29) family. (475 aa)
	SLC25A41	Solute carrier family 25 member 41; Belongs to the mitochondrial carrier (TC 2.A.29) family. (304 aa)
	CYB5RL	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (312 aa)
	GFPT1	Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
	SLC25A25	Solute carrier family 25 member 25; Belongs to the mitochondrial carrier (TC 2.A.29) family. (514 aa)
	EDF1	Endothelial differentiation related factor 1. (148 aa)
	HIRIP3	HIRA interacting protein 3. (573 aa)
	MPI	Mannose-6-phosphate isomerase. (423 aa)
	CRISP1	Cysteine rich secretory protein 1; Belongs to the CRISP family. (249 aa)
	GNPDA2	Glucosamine-6-phosphate isomerase. (276 aa)
	FPGT	Fucose-1-phosphate guanylyltransferase. (599 aa)
	GLIPR1L1	GLIPR1 like 1; Belongs to the CRISP family. (202 aa)
	Rabggtb	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (331 aa)
	PI16	Peptidase inhibitor 16; Belongs to the CRISP family. (476 aa)
	LOC101957297	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (474 aa)
	CYB5R2	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (291 aa)
	SNX8	Sorting nexin 8. (455 aa)
	CYB5R3	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (294 aa)
	ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa)
	Sypl1	MARVEL domain-containing protein. (261 aa)
	GMDS	GDP-mannose 4,6-dehydratase. (372 aa)
	LMCD1	LIM and cysteine rich domains 1. (364 aa)
	NPL	N-acetylneuraminate pyruvate lyase; Belongs to the DapA family. (319 aa)
	LOC101971483	Acyl_transf_3 domain-containing protein. (609 aa)
	I3NEP8_ICTTR	Uncharacterized protein. (329 aa)
	EEF1AKMT3	EEF1A lysine methyltransferase 3. (226 aa)
	OVGP1	Oviductal glycoprotein 1; Belongs to the glycosyl hydrolase 18 family. (517 aa)
	CYB5R1	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
	VCPKMT	Valosin containing protein lysine methyltransferase. (225 aa)
	GALE	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (348 aa)
	PGM3	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (542 aa)
	ENSSTOP00000024385	MARVEL domain-containing protein. (236 aa)
	CRISP3	Cysteine rich secretory protein 3; Belongs to the CRISP family. (244 aa)
	LOC101959484	Uncharacterized protein. (343 aa)
	METTL7A	Methyltransferase like 7A. (244 aa)
	ENSSTOP00000026291	Uncharacterized protein. (256 aa)
	TSTA3	Tissue specific transplantation antigen P35B. (329 aa)
	NAA11	N(alpha)-acetyltransferase 11, NatA catalytic subunit. (224 aa)
	GNE	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase. (753 aa)
	GALT	Galactose-1-phosphate uridylyltransferase. (379 aa)
	CTBS	Chitobiase; Belongs to the glycosyl hydrolase 18 family. (381 aa)
	PMM1	Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (262 aa)
	GMPPA	GDP-mannose pyrophosphorylase A. (425 aa)
	ENSSTOP00000029807	Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX. (290 aa)
	ENSSTOP00000029819	Glucosamine_iso domain-containing protein. (267 aa)
	Hexa	Beta-hexosaminidase. (527 aa)
	GLIPR2	GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
	ENSSTOP00000032400	Uncharacterized protein. (338 aa)
	LOC101962251	DUF3719 domain-containing protein. (401 aa)
	HK1	Hexokinase 1. (920 aa)
	PGM1	Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (580 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Amdhd2	CYB5R4	ENSSTOP00000012027	ENSSTOP00000008410	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Cytochrome b5 reductase 4.	0.422
Amdhd2	ENSSTOP00000029819	ENSSTOP00000012027	ENSSTOP00000029819	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucosamine_iso domain-containing protein.	0.992
Amdhd2	Fam149a	ENSSTOP00000012027	ENSSTOP00000008928	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	DUF3719 domain-containing protein.	0.613
Amdhd2	Fam149b1	ENSSTOP00000012027	ENSSTOP00000001917	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	DUF3719 domain-containing protein.	0.613
Amdhd2	GALE	ENSSTOP00000012027	ENSSTOP00000024279	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.651
Amdhd2	GALK1	ENSSTOP00000012027	ENSSTOP00000011949	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Galactokinase 1.	0.473
Amdhd2	GCK	ENSSTOP00000012027	ENSSTOP00000002448	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Phosphotransferase.	0.675
Amdhd2	GCKR	ENSSTOP00000012027	ENSSTOP00000004530	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucokinase regulator.	0.953
Amdhd2	GFPT1	ENSSTOP00000012027	ENSSTOP00000015842	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glutamine--fructose-6-phosphate transaminase 1.	0.929
Amdhd2	GFPT2	ENSSTOP00000012027	ENSSTOP00000002489	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glutamine-fructose-6-phosphate transaminase 2.	0.929
Amdhd2	GMPPA	ENSSTOP00000012027	ENSSTOP00000029649	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	GDP-mannose pyrophosphorylase A.	0.782
Amdhd2	GMPPB	ENSSTOP00000012027	ENSSTOP00000012300	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	GDP-mannose pyrophosphorylase B.	0.782
Amdhd2	GNE	ENSSTOP00000012027	ENSSTOP00000027956	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase.	0.954
Amdhd2	GNPDA2	ENSSTOP00000012027	ENSSTOP00000017486	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucosamine-6-phosphate isomerase.	0.997
Amdhd2	GNPNAT1	ENSSTOP00000012027	ENSSTOP00000013003	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucosamine 6-phosphate N-acetyltransferase.	0.902
Amdhd2	GPI	ENSSTOP00000012027	ENSSTOP00000002308	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.941
Amdhd2	Gnpda1	ENSSTOP00000012027	ENSSTOP00000014777	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Glucosamine-6-phosphate isomerase.	0.993
Amdhd2	HAS1	ENSSTOP00000012027	ENSSTOP00000008502	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Hyaluronan synthase 1.	0.412
Amdhd2	HAS2	ENSSTOP00000012027	ENSSTOP00000013575	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Hyaluronan synthase 2.	0.412
Amdhd2	HAS3	ENSSTOP00000012027	ENSSTOP00000014833	N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.	Hyaluronan synthase 3.	0.412