(79 nodes) Retinol metabolism network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP26C1	Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (518 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
	LOC101965174	Uncharacterized protein; Belongs to the cytochrome P450 family. (467 aa)
	AWAT2	Acyl-CoA wax alcohol acyltransferase 2. (333 aa)
	CYP4B1	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa)
	RPE65	Retinoid isomerohydrolase RPE65. (533 aa)
	DEPDC1	DEP domain containing 1. (806 aa)
	I3M0I5_ICTTR	Uncharacterized protein. (485 aa)
	SDR16C5	Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
	ALDH1A1	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
	DHRS13	Dehydrogenase/reductase 13. (377 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	ADH7	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (374 aa)
	Aox1	Aldehyde oxidase 1. (1334 aa)
	BCO1	Beta-carotene oxygenase 1. (471 aa)
	CARMIL3	Capping protein regulator and myosin 1 linker 3. (1375 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (520 aa)
	DHRS9	Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	RDH5	Retinol dehydrogenase 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (318 aa)
	AWAT1	Acyl-CoA wax alcohol acyltransferase 1. (328 aa)
	BCO2	Beta-carotene oxygenase 2. (575 aa)
	LOC101975342	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (332 aa)
	LOC101977410	Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
	I3MLS0_ICTTR	Uncharacterized protein; Belongs to the cytochrome P450 family. (395 aa)
	LOC101975676	Uncharacterized protein; Belongs to the cytochrome P450 family. (151 aa)
	LOC101971685	Uncharacterized protein. (503 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (523 aa)
	LOC101967929	Uncharacterized protein; Belongs to the cytochrome P450 family. (480 aa)
	Rdh8	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
	EXOC6	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (687 aa)
	CYP26A1	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
	RDH12	Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	LOC101978636	Uncharacterized protein; Belongs to the cytochrome P450 family. (525 aa)
	LOC101971054	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	LOC101976366	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (332 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (488 aa)
	LOC101974782	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	LOC101978322	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	LOC101958990	Uncharacterized protein; Belongs to the cytochrome P450 family. (434 aa)
	WWOX	WW domain containing oxidoreductase. (415 aa)
	LOC101969633	Uncharacterized protein. (279 aa)
	RETSAT	Retinol saturase. (610 aa)
	EXOC6B	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (811 aa)
	PNPLA4	Patatin like phospholipase domain containing 4. (253 aa)
	LOC101973439	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	UGT2A2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	LOC101975961	Uncharacterized protein. (503 aa)
	LOC101969097	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (341 aa)
	RDH16	Retinol dehydrogenase 16; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	LOC101976546	PKS_ER domain-containing protein. (375 aa)
	LOC101965594	Uncharacterized protein. (1355 aa)
	LOC101972885	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	I3N0A8_ICTTR	Uncharacterized protein. (300 aa)
	SDR9C7	Short chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (313 aa)
	LOC101968812	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
	LOC101973702	Uncharacterized protein. (1262 aa)
	LOC101975801	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (331 aa)
	LOC101976849	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	LOC101964273	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
	I3N708_ICTTR	Uncharacterized protein; Belongs to the cytochrome P450 family. (476 aa)
	LOC101977482	Uncharacterized protein; Belongs to the cytochrome P450 family. (340 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (515 aa)
	LOC101972028	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	LOC101974308	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (332 aa)
	LOC101966223	Uncharacterized protein; Belongs to the cytochrome P450 family. (206 aa)
	LOC101961668	Uncharacterized protein. (284 aa)
	DGAT2L6	Diacylglycerol O-acyltransferase 2 like 6. (337 aa)
	LRAT	Lecithin retinol acyltransferase. (230 aa)
	LOC101976375	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	DGAT1	O-acyltransferase. (500 aa)
	LOC101955536	Uncharacterized protein. (346 aa)
	LOC101964311	Uncharacterized protein. (486 aa)
	DEPDC1B	DEP domain containing 1B. (529 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (298 aa)
	HSD17B13	Hydroxysteroid 17-beta dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (220 aa)
	Rdh11	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH4	ADH7	ENSSTOP00000024209	ENSSTOP00000006088	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide.	0.796
ADH4	ALDH1A1	ENSSTOP00000024209	ENSSTOP00000002943	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family.	0.858
ADH4	ALDH1A2	ENSSTOP00000024209	ENSSTOP00000000260	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.	0.840
ADH4	ALDH1A3	ENSSTOP00000024209	ENSSTOP00000008032	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	0.840
ADH4	AWAT1	ENSSTOP00000024209	ENSSTOP00000010280	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Acyl-CoA wax alcohol acyltransferase 1.	0.505
ADH4	AWAT2	ENSSTOP00000024209	ENSSTOP00000001200	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Acyl-CoA wax alcohol acyltransferase 2.	0.794
ADH4	Aox1	ENSSTOP00000024209	ENSSTOP00000006409	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde oxidase 1.	0.800
ADH4	BCO1	ENSSTOP00000024209	ENSSTOP00000006673	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Beta-carotene oxygenase 1.	0.793
ADH4	CYP26A1	ENSSTOP00000024209	ENSSTOP00000013980	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family.	0.804
ADH4	CYP26B1	ENSSTOP00000024209	ENSSTOP00000021029	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.570
ADH4	CYP4B1	ENSSTOP00000024209	ENSSTOP00000001267	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family.	0.437
ADH4	DGAT1	ENSSTOP00000024209	ENSSTOP00000023501	Alcohol dehydrogenase 4 (class II), pi polypeptide.	O-acyltransferase.	0.787
ADH4	DGAT2L6	ENSSTOP00000024209	ENSSTOP00000022332	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Diacylglycerol O-acyltransferase 2 like 6.	0.505
ADH4	DHRS13	ENSSTOP00000024209	ENSSTOP00000003122	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Dehydrogenase/reductase 13.	0.497
ADH4	DHRS3	ENSSTOP00000024209	ENSSTOP00000031426	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.676
ADH4	DHRS9	ENSSTOP00000024209	ENSSTOP00000008873	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.648
ADH4	HSD17B13	ENSSTOP00000024209	ENSSTOP00000027676	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Hydroxysteroid 17-beta dehydrogenase 13; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.495
ADH4	I3N0A8_ICTTR	ENSSTOP00000024209	ENSSTOP00000017804	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.656
ADH4	LOC101955536	ENSSTOP00000024209	ENSSTOP00000023732	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.437
ADH4	LOC101961668	ENSSTOP00000024209	ENSSTOP00000022089	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.590