(67 nodes) Metabolism of xenobiotics by cytochrome P450 network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSD11B1L	Hydroxysteroid 11-beta dehydrogenase 1 like. (288 aa)
	LOC101975342	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (332 aa)
	GSTA4	Glutathione S-transferase alpha 4. (222 aa)
	LOC101965764	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC101964314	Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
	LOC101964325	Sulfotransferase; Belongs to the sulfotransferase 1 family. (287 aa)
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (241 aa)
	GSTO2	Glutathione S-transferase omega 2; Belongs to the GST superfamily. (248 aa)
	CYP1A1	Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (523 aa)
	DHDH	Dihydrodiol dehydrogenase. (333 aa)
	ALDH3B1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (468 aa)
	HSD11B1	Hydroxysteroid 11-beta dehydrogenase 1. (292 aa)
	LOC101963741	Uncharacterized protein. (240 aa)
	C2orf69	Chromosome 2 open reading frame 69. (371 aa)
	ALDH3A1	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (453 aa)
	LOC101973766	Aldo-keto reductase family 7 like (gene/pseudogene). (331 aa)
	MGST1	Microsomal glutathione S-transferase 1. (155 aa)
	LOC101960145	Glutathione S-transferase. (218 aa)
	ADH7	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (374 aa)
	GSTT4	Glutathione S-transferase theta 4; Belongs to the GST superfamily. (240 aa)
	ADH5	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
	GSTK1	Glutathione S-transferase kappa. (226 aa)
	MGST2	Microsomal glutathione S-transferase 2. (153 aa)
	LOC101958631	Glutathione S-transferase. (222 aa)
	LOC101964037	Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
	LOC101966838	Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (492 aa)
	LOC101964591	Glutathione S-transferase theta-2B-like. (244 aa)
	CBR3	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
	LOC101962223	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC101956983	Uncharacterized protein. (406 aa)
	HPGDS	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily. (204 aa)
	ADH4	Alcohol dehydrogenase 4 (class II), pi polypeptide. (298 aa)
	LOC101961002	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC101966550	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	LOC101958355	Uncharacterized protein. (222 aa)
	LOC101957277	Uncharacterized protein; Belongs to the cytochrome P450 family. (463 aa)
	LOC101966648	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC101959480-2	Uncharacterized protein; Belongs to the GST superfamily. (221 aa)
	LOC101959274	Uncharacterized protein; Belongs to the cytochrome P450 family. (575 aa)
	LOC101974308	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (332 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (515 aa)
	LOC101967896	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	GSTM4	Glutathione S-transferase mu 4. (218 aa)
	LOC101975801	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (331 aa)
	LOC101968812	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (531 aa)
	LOC101959378	Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
	GSTM2	Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
	LOC101958905	Uncharacterized protein; Belongs to the GST superfamily. (221 aa)
	LOC101963557	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	I3N0A8_ICTTR	Uncharacterized protein. (300 aa)
	Akr7a2	Aldo_ket_red domain-containing protein. (370 aa)
	MGST3	Microsomal glutathione S-transferase 3. (153 aa)
	LOC101976546	PKS_ER domain-containing protein. (375 aa)
	LOC101969097	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (341 aa)
	UGT2A2	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (528 aa)
	GSTM3	Glutathione S-transferase mu 3; Belongs to the GST superfamily. (225 aa)
	LOC101973439	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	LOC101975766	Uncharacterized protein. (152 aa)
	GSTP1	Glutathione S-transferase pi 1. (210 aa)
	EPHX1	Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (454 aa)
	LOC101959480	Uncharacterized protein. (222 aa)
	LOC110599253	Sulfotransferase; Belongs to the sulfotransferase 1 family. (285 aa)
	LOC101974782	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (488 aa)
	LOC101976366	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (332 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH4	ADH7	ENSSTOP00000024209	ENSSTOP00000006088	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide.	0.796
ADH4	ALDH3A1	ENSSTOP00000024209	ENSSTOP00000007624	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.895
ADH4	ALDH3B1	ENSSTOP00000024209	ENSSTOP00000013579	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.876
ADH4	CBR3	ENSSTOP00000024209	ENSSTOP00000028670	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.496
ADH4	CYP2E1	ENSSTOP00000024209	ENSSTOP00000000498	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family.	0.812
ADH4	GSTA4	ENSSTOP00000024209	ENSSTOP00000011202	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase alpha 4.	0.667
ADH4	GSTK1	ENSSTOP00000024209	ENSSTOP00000004509	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase kappa.	0.797
ADH4	GSTM2	ENSSTOP00000024209	ENSSTOP00000018126	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein; Belongs to the GST superfamily.	0.546
ADH4	GSTM3	ENSSTOP00000024209	ENSSTOP00000016653	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase mu 3; Belongs to the GST superfamily.	0.804
ADH4	GSTM4	ENSSTOP00000024209	ENSSTOP00000020150	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase mu 4.	0.546
ADH4	GSTO1	ENSSTOP00000024209	ENSSTOP00000012004	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase omega 1; Belongs to the GST superfamily.	0.673
ADH4	GSTO2	ENSSTOP00000024209	ENSSTOP00000012010	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase omega 2; Belongs to the GST superfamily.	0.673
ADH4	GSTP1	ENSSTOP00000024209	ENSSTOP00000016112	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase pi 1.	0.828
ADH4	GSTT4	ENSSTOP00000024209	ENSSTOP00000005852	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase theta 4; Belongs to the GST superfamily.	0.799
ADH4	HPGDS	ENSSTOP00000024209	ENSSTOP00000025163	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.812
ADH4	HSD11B1	ENSSTOP00000024209	ENSSTOP00000014804	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Hydroxysteroid 11-beta dehydrogenase 1.	0.524
ADH4	HSD11B1L	ENSSTOP00000024209	ENSSTOP00000015126	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Hydroxysteroid 11-beta dehydrogenase 1 like.	0.517
ADH4	I3N0A8_ICTTR	ENSSTOP00000024209	ENSSTOP00000017804	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.656
ADH4	LOC101958355	ENSSTOP00000024209	ENSSTOP00000022769	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Uncharacterized protein.	0.667
ADH4	LOC101958631	ENSSTOP00000024209	ENSSTOP00000003223	Alcohol dehydrogenase 4 (class II), pi polypeptide.	Glutathione S-transferase.	0.558