(95 nodes) EGFR tyrosine kinase inhibitor resistance network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	I3N654_ICTTR	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	JAK1	Tyrosine-protein kinase. (1142 aa)
	Rps6kb1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	ERAS	ES cell expressed Ras. (227 aa)
	GAS6	Growth arrest specific 6. (654 aa)
	Foxo3	Forkhead box O3. (673 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
	RPS6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (219 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1248 aa)
	CEP152	Centrosomal protein 152. (1507 aa)
	ENSSTOP00000024467	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (233 aa)
	TGFA	Transforming growth factor alpha. (159 aa)
	LOC101968118	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
	Bcl2l1	BH4_2 domain-containing protein. (233 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	ENSSTOP00000026508	BH4_2 domain-containing protein. (224 aa)
	NF1	Neurofibromin 1. (2473 aa)
	LOC101975023	CSD_1 domain-containing protein. (729 aa)
	ENSSTOP00000028121	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (236 aa)
	ENSSTOP00000028389	Uncharacterized protein. (113 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	AXL	AXL receptor tyrosine kinase. (887 aa)
	Pik3r3	Uncharacterized protein. (461 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	IGF1	Insulin like growth factor 1. (166 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
	Csde1	Uncharacterized protein. (555 aa)
	Shc2	Uncharacterized protein. (581 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)
	NRG1	Neuregulin 1. (700 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	I3LWF9_ICTTR	SH2 domain-containing protein. (118 aa)
	MAPK3	Mitogen-activated protein kinase. (361 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
	I3LZZ8_ICTTR	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (223 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
	Map2k2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (754 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
	PDGFA	Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1256 aa)
	ARAF	A-Raf proto-oncogene, serine/threonine kinase. (606 aa)
	FGFR2	Fibroblast growth factor receptor. (823 aa)
	PDGFD	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	EGFR	Receptor protein-tyrosine kinase. (1192 aa)
	STAT3	Signal transducer and activator of transcription. (748 aa)
	Eif4ebp1	Uncharacterized protein. (118 aa)
	BAD	BCL2 associated agonist of cell death. (208 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	IL6R	Interleukin 6 receptor. (409 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	LOC101962660	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
	TBCA	Tubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1368 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	MAPK1	Mitogen-activated protein kinase. (331 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
	LOC101965906	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	Fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (144 aa)
	BCL2	BCL2 apoptosis regulator. (195 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	GAB1	GRB2 associated binding protein 1. (724 aa)
	I3MWX8_ICTTR	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (253 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
	PPP1R14B	Protein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
	NRG2	Neuregulin 2. (767 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	LOC101960206	Uncharacterized protein. (207 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1380 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSSTOP00000028457	ENSSTOP00000002612	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.968
AKT1	AKT3	ENSSTOP00000028457	ENSSTOP00000009513	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.896
AKT1	ARAF	ENSSTOP00000028457	ENSSTOP00000003497	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	A-Raf proto-oncogene, serine/threonine kinase.	0.920
AKT1	BAD	ENSSTOP00000028457	ENSSTOP00000007563	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated agonist of cell death.	0.979
AKT1	BAX	ENSSTOP00000028457	ENSSTOP00000012508	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 associated X, apoptosis regulator.	0.606
AKT1	BCL2	ENSSTOP00000028457	ENSSTOP00000016154	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BCL2 apoptosis regulator.	0.934
AKT1	BCL2L11	ENSSTOP00000028457	ENSSTOP00000023052	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.511
AKT1	BRAF	ENSSTOP00000028457	ENSSTOP00000002302	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	B-Raf proto-oncogene, serine/threonine kinase.	0.736
AKT1	Bcl2l1	ENSSTOP00000028457	ENSSTOP00000024857	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BH4_2 domain-containing protein.	0.888
AKT1	Csde1	ENSSTOP00000028457	ENSSTOP00000031051	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.431
AKT1	EGFR	ENSSTOP00000028457	ENSSTOP00000006038	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.528
AKT1	EIF4E	ENSSTOP00000028457	ENSSTOP00000001986	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.456
AKT1	ENSSTOP00000026508	ENSSTOP00000028457	ENSSTOP00000026508	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BH4_2 domain-containing protein.	0.888
AKT1	ENSSTOP00000028389	ENSSTOP00000028457	ENSSTOP00000028389	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.522
AKT1	ERAS	ENSSTOP00000028457	ENSSTOP00000020926	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	ES cell expressed Ras.	0.474
AKT1	ERBB2	ENSSTOP00000028457	ENSSTOP00000003374	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.419
AKT1	ERBB3	ENSSTOP00000028457	ENSSTOP00000023609	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Erb-b2 receptor tyrosine kinase 3.	0.609
AKT1	Eif4ebp1	ENSSTOP00000028457	ENSSTOP00000006087	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.522
AKT1	Fgf2	ENSSTOP00000028457	ENSSTOP00000015653	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.540
AKT1	Foxo3	ENSSTOP00000028457	ENSSTOP00000022009	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box O3.	0.977