62 items (Ictidomys tridecemlineatus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

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	ADAT2	Adenosine deaminase tRNA specific 2. (191 aa)
	Pole3	CBFD_NFYB_HMF domain-containing protein. (147 aa)
	Hmgb3	High mobility group box 3. (200 aa)
	Glipr1l2	SCP domain-containing protein; Belongs to the CRISP family. (194 aa)
	APEX2	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
	Pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	ENSSTOP00000025372	CBFD_NFYB_HMF domain-containing protein. (134 aa)
	POLE4	DNA polymerase epsilon 4, accessory subunit. (115 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (486 aa)
	LIG1	DNA ligase. (922 aa)
	ENSSTOP00000026616	Uncharacterized protein. (174 aa)
	Hmgb1	Uncharacterized protein. (188 aa)
	Mutyh	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (537 aa)
	TDG	Thymine DNA glycosylase. (411 aa)
	ENSSTOP00000028611	Uncharacterized protein. (195 aa)
	CRISPLD2	Cysteine rich secretory protein LCCL domain containing 2. (548 aa)
	POLD1	DNA polymerase. (1106 aa)
	I3MJ28_ICTTR	Uncharacterized protein. (195 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (303 aa)
	GTF3C6	General transcription factor IIIC subunit 6. (211 aa)
	GEN1	GEN1 Holliday junction 5' flap endonuclease. (913 aa)
	GTF3C1	General transcription factor IIIC subunit 1. (2171 aa)
	R3HDML	R3H domain containing like. (253 aa)
	Pold4	Uncharacterized protein. (107 aa)
	METTL4	Methyltransferase like 4; Belongs to the MT-A70-like family. (472 aa)
	MBD3	Methyl-CpG binding domain protein 3. (292 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	NEIL3	Nei like DNA glycosylase 3. (607 aa)
	XRCC1	X-ray repair cross complementing 1. (632 aa)
	MGMT	O-6-methylguanine-DNA methyltransferase. (209 aa)
	I3MU87_ICTTR	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (250 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1428 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1266 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (703 aa)
	PARP3	Poly [ADP-ribose] polymerase. (529 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (469 aa)
	OGG1	8-oxoguanine DNA glycosylase. (344 aa)
	MPG	N-methylpurine DNA glycosylase. (313 aa)
	Pold3	Uncharacterized protein. (467 aa)
	VWA5A	Von Willebrand factor A domain containing 5A. (799 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	HMGB2	High mobility group box 2. (210 aa)
	I3N1G5_ICTTR	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (1263 aa)
	PARP2	Poly [ADP-ribose] polymerase. (566 aa)
	Ppil3	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
	CABP5	Calcium binding protein 5. (177 aa)
	MBD4	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (561 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2282 aa)
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
	MBD2	Methyl-CpG binding domain protein 2. (280 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	CACHD1	Cache domain containing 1. (1292 aa)
	VWA5B1	Von Willebrand factor A domain containing 5B1. (1219 aa)
	LOC101971898	Uncharacterized protein. (414 aa)
	CHRAC1	Chromatin accessibility complex subunit 1. (127 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (504 aa)
	LOC101966186	Uncharacterized protein. (159 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (313 aa)
	LIG3	DNA ligase. (1013 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (306 aa)
	NEIL1	Nei like DNA glycosylase 1. (390 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAT2	APEX1	ENSSTOP00000018799	ENSSTOP00000009066	Adenosine deaminase tRNA specific 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.636
ADAT2	APEX2	ENSSTOP00000018799	ENSSTOP00000021606	Adenosine deaminase tRNA specific 2.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.636
ADAT2	FEN1	ENSSTOP00000018799	ENSSTOP00000003021	Adenosine deaminase tRNA specific 2.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.435
ADAT2	MPG	ENSSTOP00000018799	ENSSTOP00000000883	Adenosine deaminase tRNA specific 2.	N-methylpurine DNA glycosylase.	0.483
ADAT2	NEIL1	ENSSTOP00000018799	ENSSTOP00000005171	Adenosine deaminase tRNA specific 2.	Nei like DNA glycosylase 1.	0.418
ADAT2	OGG1	ENSSTOP00000018799	ENSSTOP00000001859	Adenosine deaminase tRNA specific 2.	8-oxoguanine DNA glycosylase.	0.470
ADAT2	SMUG1	ENSSTOP00000018799	ENSSTOP00000004071	Adenosine deaminase tRNA specific 2.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.450
ADAT2	TDG	ENSSTOP00000018799	ENSSTOP00000028371	Adenosine deaminase tRNA specific 2.	Thymine DNA glycosylase.	0.493
ADAT2	UNG	ENSSTOP00000018799	ENSSTOP00000006161	Adenosine deaminase tRNA specific 2.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.	0.600
APEX1	ADAT2	ENSSTOP00000009066	ENSSTOP00000018799	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Adenosine deaminase tRNA specific 2.	0.636
APEX1	APEX2	ENSSTOP00000009066	ENSSTOP00000021606	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.868
APEX1	ENSSTOP00000025372	ENSSTOP00000009066	ENSSTOP00000025372	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	CBFD_NFYB_HMF domain-containing protein.	0.681
APEX1	FEN1	ENSSTOP00000009066	ENSSTOP00000003021	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.994
APEX1	GEN1	ENSSTOP00000009066	ENSSTOP00000012517	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	GEN1 Holliday junction 5' flap endonuclease.	0.747
APEX1	I3MU87_ICTTR	ENSSTOP00000009066	ENSSTOP00000015682	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.885
APEX1	LIG1	ENSSTOP00000009066	ENSSTOP00000026448	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.974
APEX1	LIG3	ENSSTOP00000009066	ENSSTOP00000005449	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA ligase.	0.854
APEX1	MBD4	ENSSTOP00000009066	ENSSTOP00000016633	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.	0.640
APEX1	MGMT	ENSSTOP00000009066	ENSSTOP00000024323	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	O-6-methylguanine-DNA methyltransferase.	0.407
APEX1	MPG	ENSSTOP00000009066	ENSSTOP00000000883	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	N-methylpurine DNA glycosylase.	0.809