STRINGSTRING
SLC4A1AP SLC4A1AP RPA1 RPA1 Ppil3 Ppil3 I3N0J6_ICTTR I3N0J6_ICTTR BRCC3 BRCC3 ABRAXAS2 ABRAXAS2 TM6SF2 TM6SF2 DMC1 DMC1 RAD54L RAD54L ATRX ATRX TOP3B TOP3B PITHD1 PITHD1 MEIOB MEIOB PTGDR2 PTGDR2 MRE11 MRE11 RPA3 RPA3 ENSSTOP00000026858 ENSSTOP00000026858 ENSSTOP00000027930 ENSSTOP00000027930 TOPBP1 TOPBP1 RAD51D RAD51D ENSSTOP00000028194 ENSSTOP00000028194 SUGP1 SUGP1 LOC101955845 LOC101955845 SSBP1 SSBP1 Rad54b Rad54b N4BP2L1 N4BP2L1 CNP CNP SAP130 SAP130 ABRAXAS1 ABRAXAS1 Babam1 Babam1 EME1 EME1 LURAP1 LURAP1 Rad50 Rad50 BRIP1 BRIP1 UNC93B1 UNC93B1 Sem1 Sem1 POLD1 POLD1 Rbbp8 Rbbp8 STN1 STN1 BABAM2 BABAM2 RECQL5 RECQL5 GTF3C6 GTF3C6 SASS6 SASS6 SLF1 SLF1 YJU2 YJU2 TOP3A TOP3A NBN NBN I3LWG0_ICTTR I3LWG0_ICTTR Pold3 Pold3 Brca1 Brca1 SYCP3 SYCP3 Unc93a Unc93a BARD1 BARD1 XRCC2 XRCC2 DDX52 DDX52 POLD2 POLD2 RAD51C RAD51C MCPH1 MCPH1 MUS81 MUS81 MCFD2 MCFD2 RPA2 RPA2 ATM ATM RAD52 RAD52 C12orf66 C12orf66 BLM BLM I3M6A8_ICTTR I3M6A8_ICTTR Pold4 Pold4 RAD51B RAD51B MPHOSPH9 MPHOSPH9 XRCC3 XRCC3 Palb2 Palb2 N4BP2 N4BP2 PIF1 PIF1 FICD FICD HELQ HELQ SUGP2 SUGP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (741 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (592 aa)
Ppil3Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (161 aa)
I3N0J6_ICTTRRAP80_UIM domain-containing protein. (166 aa)
BRCC3BRCA1/BRCA2-containing complex subunit 3. (291 aa)
ABRAXAS2Abraxas 2, BRISC complex subunit. (424 aa)
TM6SF2Transmembrane 6 superfamily member 2. (376 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa)
RAD54LRAD54 like. (747 aa)
ATRXATRX chromatin remodeler. (2464 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
PITHD1PITH domain containing 1. (211 aa)
MEIOBMeiosis specific with OB-fold. (471 aa)
PTGDR2Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (404 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
RPA3Replication protein A3. (121 aa)
ENSSTOP00000026858Uncharacterized protein. (139 aa)
ENSSTOP00000027930Uncharacterized protein. (173 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa)
ENSSTOP00000028194SAE2 domain-containing protein. (75 aa)
SUGP1SURP and G-patch domain containing 1. (651 aa)
LOC101955845Cor1 domain-containing protein. (223 aa)
SSBP1Single stranded DNA binding protein 1. (183 aa)
Rad54bUncharacterized protein. (917 aa)
N4BP2L1NEDD4 binding protein 2 like 1. (240 aa)
CNP2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family. (419 aa)
SAP130Sin3A associated protein 130. (1057 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (409 aa)
Babam1BRISC and BRCA1 A complex member 1. (335 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
LURAP1Leucine rich adaptor protein 1. (239 aa)
Rad50Zinc-hook domain-containing protein. (1312 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (937 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (369 aa)
Sem1Uncharacterized protein. (70 aa)
POLD1DNA polymerase. (1106 aa)
Rbbp8CtIP_N domain-containing protein. (773 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (376 aa)
BABAM2BRISC and BRCA1 A complex member 2. (406 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (990 aa)
GTF3C6General transcription factor IIIC subunit 6. (211 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1057 aa)
YJU2YJU2 splicing factor homolog. (313 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1007 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (634 aa)
I3LWG0_ICTTRRECA_2 domain-containing protein. (187 aa)
Pold3Uncharacterized protein. (467 aa)
Brca1Uncharacterized protein. (353 aa)
SYCP3Synaptonemal complex protein 3. (235 aa)
Unc93aUncharacterized protein. (252 aa)
BARD1BRCA1 associated RING domain 1. (776 aa)
XRCC2X-ray repair cross complementing 2. (278 aa)
DDX52DExD-box helicase 52. (322 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
RAD51CRAD51 paralog C. (360 aa)
MCPH1Microcephalin 1. (807 aa)
MUS81MUS81 structure-specific endonuclease subunit. (567 aa)
MCFD2Multiple coagulation factor deficiency 2. (146 aa)
RPA2Replication protein A2. (271 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
RAD52RAD52 homolog, DNA repair protein. (422 aa)
C12orf66Chromosome 12 open reading frame 66. (445 aa)
BLMBLM RecQ like helicase. (1414 aa)
I3M6A8_ICTTRUncharacterized protein. (968 aa)
Pold4Uncharacterized protein. (107 aa)
RAD51BRAD51 paralog B. (258 aa)
MPHOSPH9M-phase phosphoprotein 9. (1103 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (349 aa)
Palb2PALB2_WD40 domain-containing protein. (384 aa)
N4BP2NEDD4 binding protein 2. (1693 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (654 aa)
FICDFIC domain containing. (458 aa)
HELQHelicase, POLQ like. (1017 aa)
SUGP2SURP and G-patch domain containing 2. (1099 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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