node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCLRE1C | DNTT | ENSSTOP00000001987 | ENSSTOP00000011414 | DNA cross-link repair 1C. | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | 0.616 |
DCLRE1C | ENKD1 | ENSSTOP00000001987 | ENSSTOP00000021527 | DNA cross-link repair 1C. | Enkurin domain containing 1. | 0.540 |
DCLRE1C | FEN1 | ENSSTOP00000001987 | ENSSTOP00000003021 | DNA cross-link repair 1C. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.482 |
DCLRE1C | GTF3C3 | ENSSTOP00000001987 | ENSSTOP00000010670 | DNA cross-link repair 1C. | General transcription factor IIIC subunit 3. | 0.700 |
DCLRE1C | LIG4 | ENSSTOP00000001987 | ENSSTOP00000023308 | DNA cross-link repair 1C. | DNA ligase. | 0.958 |
DCLRE1C | MRE11 | ENSSTOP00000001987 | ENSSTOP00000024452 | DNA cross-link repair 1C. | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. | 0.845 |
DCLRE1C | NHEJ1 | ENSSTOP00000001987 | ENSSTOP00000019173 | DNA cross-link repair 1C. | Non-homologous end joining factor 1. | 0.713 |
DCLRE1C | POLL | ENSSTOP00000001987 | ENSSTOP00000010303 | DNA cross-link repair 1C. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.760 |
DCLRE1C | POLM | ENSSTOP00000001987 | ENSSTOP00000002384 | DNA cross-link repair 1C. | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. | 0.616 |
DCLRE1C | PRKDC | ENSSTOP00000001987 | ENSSTOP00000008861 | DNA cross-link repair 1C. | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. | 0.994 |
DCLRE1C | Rad50 | ENSSTOP00000001987 | ENSSTOP00000008870 | DNA cross-link repair 1C. | Zinc-hook domain-containing protein. | 0.783 |
DCLRE1C | XRCC4 | ENSSTOP00000001987 | ENSSTOP00000021064 | DNA cross-link repair 1C. | X-ray repair cross complementing 4. | 0.763 |
DCLRE1C | XRCC5 | ENSSTOP00000001987 | ENSSTOP00000005811 | DNA cross-link repair 1C. | X-ray repair cross complementing 5. | 0.989 |
DCLRE1C | XRCC6 | ENSSTOP00000001987 | ENSSTOP00000008520 | DNA cross-link repair 1C. | X-ray repair cross complementing 6. | 0.993 |
DNTT | DCLRE1C | ENSSTOP00000011414 | ENSSTOP00000001987 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA cross-link repair 1C. | 0.616 |
DNTT | FEN1 | ENSSTOP00000011414 | ENSSTOP00000003021 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.778 |
DNTT | LIG4 | ENSSTOP00000011414 | ENSSTOP00000023308 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA ligase. | 0.809 |
DNTT | NHEJ1 | ENSSTOP00000011414 | ENSSTOP00000019173 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | Non-homologous end joining factor 1. | 0.471 |
DNTT | POLL | ENSSTOP00000011414 | ENSSTOP00000010303 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.704 |
DNTT | PRKDC | ENSSTOP00000011414 | ENSSTOP00000008861 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. | 0.662 |