STRINGSTRING
SOS1 SOS1 Pik3cd Pik3cd Pik3r3 Pik3r3 HRAS HRAS AKT1 AKT1 ENSSTOP00000028389 ENSSTOP00000028389 LOC101964641 LOC101964641 LOC101975023 LOC101975023 ALKBH4 ALKBH4 PAK3 PAK3 PIK3R1 PIK3R1 PRKCG PRKCG NRG4 NRG4 SHC1 SHC1 ERBB4 ERBB4 I3LWF9_ICTTR I3LWF9_ICTTR PAK5 PAK5 CAMK2B CAMK2B EREG EREG MAPK3 MAPK3 NCK2 NCK2 PIK3CB PIK3CB MAPK10 MAPK10 NCK1 NCK1 Pik3r2 Pik3r2 Map2k2 Map2k2 BRAF BRAF AKT2 AKT2 SHC4 SHC4 PRKCA PRKCA EPGN EPGN ERBB2 ERBB2 ARAF ARAF MYC MYC CBL CBL PLCG2 PLCG2 STAT5B STAT5B STAT5A STAT5A EGFR EGFR Eif4ebp1 Eif4ebp1 RRAD RRAD PAK2 PAK2 BAD BAD AREG AREG CRKL CRKL CAMK2A CAMK2A MAP2K1 MAP2K1 KRAS KRAS LOC101962660 LOC101962660 ELK1 ELK1 REM2 REM2 ELK3 ELK3 AKT3 AKT3 GEM GEM PLCG1 PLCG1 CBLB CBLB PRKCB PRKCB MAPK8 MAPK8 GRB2 GRB2 PAK1 PAK1 TMEFF2 TMEFF2 PIK3CA PIK3CA BTC BTC MAPK1 MAPK1 MSANTD3-TMEFF1 MSANTD3-TMEFF1 LOC101965906 LOC101965906 MSANTD3 MSANTD3 CDKN1B CDKN1B NRAS NRAS GAB1 GAB1 RPS6KB2 RPS6KB2 PPP1R14B PPP1R14B NRG2 NRG2 MAP2K4 MAP2K4 ARSI ARSI CDKN1A CDKN1A RAF1 RAF1 Pak4 Pak4 Rps6kb1 Rps6kb1 ABL2 ABL2 ERAS ERAS REM1 REM1 JUN JUN CAMK2D CAMK2D GSK3B GSK3B ERBB3 ERBB3 ABL1 ABL1 HBEGF HBEGF CAMK2G CAMK2G CEP152 CEP152 CRK CRK LOC101968118 LOC101968118 TGFA TGFA NRG1 NRG1 MTOR MTOR PTK2 PTK2 Shc2 Shc2 Csde1 Csde1 ENSSTOP00000030902 ENSSTOP00000030902 PAK6 PAK6 MAPK9 MAPK9 MAP2K7 MAP2K7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Pik3r3Uncharacterized protein. (461 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
LOC101964641Uncharacterized protein. (400 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (298 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
NRG4Neuregulin 4. (123 aa)
SHC1SHC adaptor protein 1. (583 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
I3LWF9_ICTTRSH2 domain-containing protein. (118 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
EREGEpiregulin. (163 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
NCK2Cytoplasmic protein. (380 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
NCK1Cytoplasmic protein. (377 aa)
Pik3r2Uncharacterized protein. (724 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
SHC4SHC adaptor protein 4. (630 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
EPGNEpithelial mitogen. (153 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (453 aa)
CBLCbl proto-oncogene. (870 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
BADBCL2 associated agonist of cell death. (208 aa)
AREGAmphiregulin. (252 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
ELK1ETS transcription factor ELK1. (428 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
ELK3ETS transcription factor ELK3. (407 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
CBLBCbl proto-oncogene B. (985 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BTCBetacellulin. (143 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MSANTD3-TMEFF1MSANTD3-TMEFF1 readthrough. (314 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
MSANTD3Myb/SANT DNA binding domain containing 3. (227 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
NRG2Neuregulin 2. (767 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
ARSIArylsulfatase family member I. (572 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
Pak4Protein kinase domain-containing protein. (240 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ABL2Tyrosine-protein kinase. (1142 aa)
ERASES cell expressed Ras. (227 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (309 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1248 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
CEP152Centrosomal protein 152. (1507 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TGFATransforming growth factor alpha. (159 aa)
NRG1Neuregulin 1. (700 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
Shc2Uncharacterized protein. (581 aa)
Csde1Uncharacterized protein. (555 aa)
ENSSTOP00000030902Uncharacterized protein. (380 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.