STRINGSTRING
ARSI ARSI CDKN1A CDKN1A Egln1 Egln1 I3N654_ICTTR I3N654_ICTTR PDHB PDHB EGLN2 EGLN2 ANGPT4 ANGPT4 Rps6kb1 Rps6kb1 CAMK2D CAMK2D ELOC ELOC PFKL PFKL CYBB CYBB EGLN3 EGLN3 RPS6 RPS6 LOC101965577 LOC101965577 ENSSTOP00000024013 ENSSTOP00000024013 CAMK2G CAMK2G PFKFB3 PFKFB3 ENSSTOP00000024467 ENSSTOP00000024467 LOC101968118 LOC101968118 LDHC LDHC EIF4E2 EIF4E2 PRKCG PRKCG LOC110597981 LOC110597981 PIK3R1 PIK3R1 HMOX1 HMOX1 ENO2 ENO2 SLC2A1 SLC2A1 ENSSTOP00000027444 ENSSTOP00000027444 ENSSTOP00000028121 ENSSTOP00000028121 ENSSTOP00000028389 ENSSTOP00000028389 AKT1 AKT1 Fcgbp Fcgbp ENSSTOP00000028717 ENSSTOP00000028717 PDK1 PDK1 Pik3r3 Pik3r3 Pik3cd Pik3cd LOC101972267 LOC101972267 IGF1 IGF1 TEK TEK NOS3 NOS3 HK1 HK1 MTOR MTOR Ldha Ldha CAMK2B CAMK2B HKDC1 HKDC1 IFNGR2 IFNGR2 ALDOC ALDOC EDN1 EDN1 ENO3 ENO3 EP300 EP300 SERPINE1 SERPINE1 Aldoa Aldoa MAPK3 MAPK3 INSR INSR PIK3CB PIK3CB Pik3r2 Pik3r2 PFKM PFKM Pgk1 Pgk1 EIF4E1B EIF4E1B I3LZZ8_ICTTR I3LZZ8_ICTTR EIF4E EIF4E Map2k2 Map2k2 HK2 HK2 ENO4 ENO4 AKT2 AKT2 ANGPT2 ANGPT2 PRKCA PRKCA TFRC TFRC ERBB2 ERBB2 HK3 HK3 I3M4W8_ICTTR I3M4W8_ICTTR Hif1a Hif1a CREBBP CREBBP PLCG2 PLCG2 TIMP1 TIMP1 PFKP PFKP EGFR EGFR STAT3 STAT3 Eif4ebp1 Eif4ebp1 ALDOB ALDOB Gapdh Gapdh I3MA50_ICTTR I3MA50_ICTTR ANGPT1 ANGPT1 VEGFA VEGFA CAMK2A CAMK2A LTF LTF MAP2K1 MAP2K1 IL6R IL6R LOC101962660 LOC101962660 TBCA TBCA AKT3 AKT3 IGF1R IGF1R NFKB1 NFKB1 PLCG1 PLCG1 ENO1 ENO1 PRKCB PRKCB MKNK2 MKNK2 PIK3CA PIK3CA LTBR LTBR EPO EPO VHL VHL TF TF CUL2 CUL2 MAPK1 MAPK1 IFNG IFNG PDHA1 PDHA1 Rbx1 Rbx1 LOC101965906 LOC101965906 Ldhb Ldhb CDKN1B CDKN1B LOC101955809 LOC101955809 BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR I3MWX8_ICTTR I3MWX8_ICTTR RPS6KB2 RPS6KB2 Ins Ins NOS2 NOS2 RELA RELA IFNGR1 IFNGR1 TLR4 TLR4 I3N090_ICTTR I3N090_ICTTR FLT1 FLT1 I3N110_ICTTR I3N110_ICTTR I3N248_ICTTR I3N248_ICTTR LOC101960206 LOC101960206
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARSIArylsulfatase family member I. (572 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
Egln1Fe2OG dioxygenase domain-containing protein. (127 aa)
I3N654_ICTTR40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (417 aa)
ANGPT4Angiopoietin 4. (496 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
ELOCSkp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (219 aa)
LOC101965577Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (325 aa)
ENSSTOP00000024013Uncharacterized protein. (102 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (544 aa)
ENSSTOP0000002446740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (233 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (323 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC110597981Uncharacterized protein. (137 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HMOX1Heme oxygenase 1. (288 aa)
ENO2Enolase 2. (434 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
ENSSTOP00000027444Uncharacterized protein; Belongs to the LDH/MDH superfamily. (301 aa)
ENSSTOP0000002812140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (236 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FcgbpUncharacterized protein. (2584 aa)
ENSSTOP00000028717RING-type domain-containing protein. (95 aa)
PDK1Protein-serine/threonine kinase. (436 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
LOC101972267Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (275 aa)
IGF1Insulin like growth factor 1. (166 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
HK1Hexokinase 1. (920 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
LdhaL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
IFNGR2Interferon gamma receptor 2. (306 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
EDN1Endothelin 1. (202 aa)
ENO3Enolase 3. (434 aa)
EP300E1A binding protein p300. (2423 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
AldoaFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (417 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Pik3r2Uncharacterized protein. (724 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
Pgk1Phosphoglycerate kinase. (417 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (241 aa)
I3LZZ8_ICTTR40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (223 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (218 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
HK2Hexokinase 2. (917 aa)
ENO4Enolase 4. (620 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
ANGPT2Angiopoietin 2. (495 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
TFRCTransferrin receptor. (760 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
HK3Hexokinase 3. (867 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
Hif1aUncharacterized protein. (821 aa)
CREBBPCREB binding protein. (2410 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (206 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
GapdhGlyceraldehyde-3-phosphate dehydrogenase. (346 aa)
I3MA50_ICTTRUncharacterized protein. (220 aa)
ANGPT1Angiopoietin 1. (497 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
LTFLactotransferrin; Belongs to the transferrin family. (709 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
IL6RInterleukin 6 receptor. (409 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
ENO1Enolase 1. (434 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LTBRLymphotoxin beta receptor. (435 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
VHLVon Hippel-Lindau tumor suppressor. (182 aa)
TFTransferrin; Belongs to the transferrin family. (694 aa)
CUL2Cullin 2; Belongs to the cullin family. (745 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
Rbx1RING-type domain-containing protein. (108 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
LdhbL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (324 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
LOC101955809Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1335 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
I3MWX8_ICTTR40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (253 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
I3N110_ICTTRRING-type domain-containing protein. (147 aa)
I3N248_ICTTRUncharacterized protein. (93 aa)
LOC101960206Uncharacterized protein. (207 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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