STRINGSTRING
FBXO32 FBXO32 MAPK10 MAPK10 Pik3r2 Pik3r2 GABARAPL1 GABARAPL1 TSSK4 TSSK4 Map2k2 Map2k2 BRAF BRAF STK11 STK11 SKP2 SKP2 AKT2 AKT2 HOMER1 HOMER1 SGK3 SGK3 ARAF ARAF SLC35E3 SLC35E3 SETD7 SETD7 ATM ATM I3M4W8_ICTTR I3M4W8_ICTTR CREBBP CREBBP LOC101967743 LOC101967743 IKBKB IKBKB TNFSF10 TNFSF10 BCL6B BCL6B PLK3 PLK3 IL10 IL10 PRKAG3 PRKAG3 TSSK3 TSSK3 EGFR EGFR STAT3 STAT3 FBXO25 FBXO25 CDK3 CDK3 NOSTRIN NOSTRIN G6PC3 G6PC3 G6PC2 G6PC2 NLK NLK PCK2 PCK2 SUCO SUCO Faslg Faslg FOXJ3 FOXJ3 RRAD RRAD CAT CAT HOMER2 HOMER2 MAP2K1 MAP2K1 STK4 STK4 KRAS KRAS Foxo1 Foxo1 LOC101962660 LOC101962660 TGFB1 TGFB1 SGK2 SGK2 SMAD3 SMAD3 PRKAA2 PRKAA2 REM2 REM2 AKT3 AKT3 GEM GEM FOXJ2 FOXJ2 PRMT3 PRMT3 IGF1R IGF1R PRMT8 PRMT8 ATG12 ATG12 PLK1 PLK1 BNIP3 BNIP3 MAPK8 MAPK8 GRB2 GRB2 PIK3CA PIK3CA PDPK1 PDPK1 MYO9B MYO9B MYO9A MYO9A TGFBR1 TGFBR1 PRKAG1 PRKAG1 Mdm2 Mdm2 MAPK1 MAPK1 PCK1 PCK1 MAPK12 MAPK12 MAPK11 MAPK11 CHUK CHUK Sgk1 Sgk1 LOC101965906 LOC101965906 CDKN1B CDKN1B SIRT1 SIRT1 NRAS NRAS GABARAP GABARAP PTEN PTEN RASL11B RASL11B I3MUQ5_ICTTR I3MUQ5_ICTTR Ccnd2 Ccnd2 I3MVL6_ICTTR I3MVL6_ICTTR G6PC G6PC GADD45G GADD45G RNF6 RNF6 SMAD4 SMAD4 RAG1 RAG1 Ins Ins Homer3 Homer3 LOC101975126 LOC101975126 FOXO6 FOXO6 SLC2A4 SLC2A4 PRKAB1 PRKAB1 Sod2 Sod2 PLK2 PLK2 LDLRAD4 LDLRAD4 CCND1 CCND1 SNAPIN SNAPIN EP300 EP300 RBL2 RBL2 Plk5 Plk5 Csde1 Csde1 PRKAB2 PRKAB2 USP7 USP7 MAPK9 MAPK9 ENSSTOP00000030245 ENSSTOP00000030245 SOS1 SOS1 IGF1 IGF1 Pik3cd Pik3cd Pik3r3 Pik3r3 CCNB1 CCNB1 CDK2 CDK2 HRAS HRAS AKT1 AKT1 LOC101975023 LOC101975023 RASGEF1B RASGEF1B PRKAG2 PRKAG2 PIK3R1 PIK3R1 LOC101974796 LOC101974796 TGFBR2 TGFBR2 LOC101968118 LOC101968118 BCL6 BCL6 RASGEF1A RASGEF1A ENSSTOP00000024463 ENSSTOP00000024463 PRMT1 PRMT1 PRKAA1 PRKAA1 MAPK13 MAPK13 TSSK1B TSSK1B CCNG2 CCNG2 MAPK14 MAPK14 BCL2L11 BCL2L11 IRS4 IRS4 I3NE23_ICTTR I3NE23_ICTTR FOXO4 FOXO4 TGFB3 TGFB3 GABARAPL2 GABARAPL2 Foxo3 Foxo3 I3NC46_ICTTR I3NC46_ICTTR REM1 REM1 TSSK6 TSSK6 S1PR4 S1PR4 PLK4 PLK4 GADD45A GADD45A GRAP GRAP CDKN2B CDKN2B ERAS ERAS LOC101960423 LOC101960423 RAG2 RAG2 RAF1 RAF1 CDKN1A CDKN1A FOXG1 FOXG1 LOC101960206 LOC101960206 GADD45B GADD45B S1PR1 S1PR1 Cdkn2d Cdkn2d TSSK2 TSSK2 IRS1 IRS1 I3N090_ICTTR I3N090_ICTTR MAPK3 MAPK3 INSR INSR AGAP2 AGAP2 TGFB2 TGFB2 PIK3CB PIK3CB RNF111 RNF111 Ccnb2 Ccnb2 PMEPA1 PMEPA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBXO32F-box protein 32. (355 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
TSSK4Testis specific serine kinase 4. (292 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
SKP2S-phase kinase associated protein 2. (401 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
HOMER1Homer scaffold protein 1. (363 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
SLC35E3Solute carrier family 35 member E3. (313 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
ATMATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2618 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
CREBBPCREB binding protein. (2410 aa)
LOC101967743Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (416 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (296 aa)
BCL6BBCL6B transcription repressor. (474 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
IL10Interleukin 10. (178 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
FBXO25F-box protein 25. (366 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (304 aa)
NOSTRINNitric oxide synthase trafficking. (505 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
SUCOSUN domain containing ossification factor. (1253 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
FOXJ3Forkhead box J3. (622 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
HOMER2Homer scaffold protein 2. (354 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
STK4Serine/threonine kinase 4. (488 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (366 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
FOXJ2Forkhead box J2. (574 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (530 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (369 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PLK1Serine/threonine-protein kinase PLK. (601 aa)
BNIP3BCL2 interacting protein 3. (217 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2090 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2638 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
Sgk1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (454 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
SIRT1Sirtuin 1. (602 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
RASL11BRAS like family 11 member B. (248 aa)
I3MUQ5_ICTTRRING-type domain-containing protein. (239 aa)
Ccnd2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (288 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
RNF6Ring finger protein 6. (683 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
Homer3WH1 domain-containing protein. (359 aa)
LOC101975126Uncharacterized protein. (498 aa)
FOXO6Forkhead box O6. (370 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PLK2Serine/threonine-protein kinase PLK. (683 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
CCND1Cyclin D1. (250 aa)
SNAPINSNAP associated protein. (125 aa)
EP300E1A binding protein p300. (2423 aa)
RBL2RB transcriptional corepressor like 2. (1161 aa)
Plk5Uncharacterized protein. (608 aa)
Csde1Uncharacterized protein. (555 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1085 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000030245Uncharacterized protein. (174 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
IGF1Insulin like growth factor 1. (166 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Pik3r3Uncharacterized protein. (461 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (429 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
RASGEF1BRasGEF domain family member 1B. (559 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LOC101974796Uncharacterized protein; Belongs to the cyclin family. (387 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
BCL6BCL6 transcription repressor. (706 aa)
RASGEF1ARasGEF domain family member 1A. (489 aa)
ENSSTOP00000024463RING-type domain-containing protein. (209 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
TSSK1BTestis specific serine kinase 1B; Belongs to the protein kinase superfamily. (369 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
IRS4Insulin receptor substrate 4. (1228 aa)
I3NE23_ICTTRANK_REP_REGION domain-containing protein. (150 aa)
FOXO4Forkhead box O4. (505 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GABARAPL2GABA type A receptor associated protein like 2. (123 aa)
Foxo3Forkhead box O3. (673 aa)
I3NC46_ICTTRNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (397 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (309 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
S1PR4Sphingosine-1-phosphate receptor 4. (383 aa)
PLK4Polo like kinase 4. (909 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
GRAPUncharacterized protein. (157 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (162 aa)
ERASES cell expressed Ras. (227 aa)
LOC101960423Protein kinase domain-containing protein. (473 aa)
RAG2Recombination activating 2. (526 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (162 aa)
FOXG1Forkhead box G1. (428 aa)
LOC101960206Uncharacterized protein. (207 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (381 aa)
Cdkn2dANK_REP_REGION domain-containing protein. (166 aa)
TSSK2Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (358 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1116 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RNF111Ring finger protein 111. (984 aa)
Ccnb2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (398 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (264 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (18%) [HD]