STRINGSTRING
I3N6R6_ICTTR I3N6R6_ICTTR ADCY5 ADCY5 SHC1 SHC1 CYTH2 CYTH2 I3LWF9_ICTTR I3LWF9_ICTTR PIP5K1A PIP5K1A Pla2g4b Pla2g4b KIT KIT MAPK3 MAPK3 RAPGEF3 RAPGEF3 INSR INSR PLA2G4C PLA2G4C RALB RALB PTGFR PTGFR PIK3CB PIK3CB DGKI DGKI PIK3CG PIK3CG PDGFC PDGFC RAPGEF4 RAPGEF4 GNA13 GNA13 RRAS RRAS Pik3r2 Pik3r2 Map2k2 Map2k2 ADCY4 ADCY4 AGPAT4 AGPAT4 AKT2 AKT2 SHC4 SHC4 GAB2 GAB2 PDGFA PDGFA CXCL8 CXCL8 TSC1 TSC1 RHEBL1 RHEBL1 ADCY6 ADCY6 PDGFD PDGFD RHEB RHEB Rhoa Rhoa CYTH1 CYTH1 ADCY2 ADCY2 ADCY9 ADCY9 ZNF408 ZNF408 F2 F2 PIK3R6 PIK3R6 PIK3R5 PIK3R5 LPAR3 LPAR3 PLCG2 PLCG2 SYK SYK PTRHD1 PTRHD1 ADCY3 ADCY3 GRM8 GRM8 FCER1G FCER1G EGFR EGFR FYN FYN DNM3 DNM3 PTK6 PTK6 MS4A2 MS4A2 SRMS SRMS GRM3 GRM3 F2R F2R AVPR2 AVPR2 DGKK DGKK AGPAT1 AGPAT1 ADCY1 ADCY1 MAP2K1 MAP2K1 Arf1 Arf1 KRAS KRAS LOC101962660 LOC101962660 DGKH DGKH PLD1 PLD1 AGPAT3 AGPAT3 AKT3 AKT3 Ralgds Ralgds DGKD DGKD PDGFRA PDGFRA PLCG1 PLCG1 SPHK2 SPHK2 MRAS MRAS GRB2 GRB2 GRM7 GRM7 PIK3CA PIK3CA TSC2 TSC2 CXCR2 CXCR2 CXCR1 CXCR1 I3MM52_ICTTR I3MM52_ICTTR PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F DGKQ DGKQ MAPK1 MAPK1 PLD2 PLD2 PLCB1 PLCB1 LOC101965906 LOC101965906 I3MSG9_ICTTR I3MSG9_ICTTR CYTH4 CYTH4 AVPR1A AVPR1A NRAS NRAS GAB1 GAB1 GRM4 GRM4 AGT AGT AGTR1 AGTR1 AVP AVP PLPP2 PLPP2 Ins Ins AVPR1B AVPR1B LPAR5 LPAR5 LOC101959358 LOC101959358 DNM2 DNM2 GPR55 GPR55 LPAR6 LPAR6 GRM2 GRM2 PDGFB PDGFB RUFY4 RUFY4 Rhoc Rhoc RRAS2 RRAS2 PTPN11 PTPN11 LOC101960968 LOC101960968 LPAR4 LPAR4 ERAS ERAS SPHK1 SPHK1 GNA12 GNA12 LPAR1 LPAR1 Plpp3 Plpp3 JMJD7 JMJD7 GRM1 GRM1 RALA RALA PIP5K1B PIP5K1B AGPAT2 AGPAT2 ARF6 ARF6 GRM6 GRM6 PDGFRB PDGFRB LPAR2 LPAR2 AGPAT5 AGPAT5 CEP152 CEP152 PLCB4 PLCB4 LOC101968118 LOC101968118 PLPP1 PLPP1 PIK3R1 PIK3R1 Gnas Gnas DGKG DGKG PLCB2 PLCB2 LOC101967288 LOC101967288 ENSSTOP00000027636 ENSSTOP00000027636 LOC101975023 LOC101975023 ENSSTOP00000028111 ENSSTOP00000028111 AKT1 AKT1 KITLG KITLG HRAS HRAS ADCY7 ADCY7 Pik3r3 Pik3r3 Pik3cd Pik3cd DNM1 DNM1 SOS1 SOS1 DGKB DGKB PTK2B PTK2B ADCY8 ADCY8 PLCB3 PLCB3 LOC101962636 LOC101962636 DGKA DGKA ENSSTOP00000031001 ENSSTOP00000031001 Csde1 Csde1 Shc2 Shc2 PIP5K1C PIP5K1C PLA2G4A PLA2G4A DGKZ DGKZ GRM5 GRM5 CYTH3 CYTH3 MTOR MTOR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I3N6R6_ICTTRANF_receptor domain-containing protein. (186 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
SHC1SHC adaptor protein 1. (583 aa)
CYTH2Uncharacterized protein. (410 aa)
I3LWF9_ICTTRSH2 domain-containing protein. (118 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (537 aa)
Pla2g4bPhospholipase A2. (774 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (898 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
RALBRAS like proto-oncogene B. (206 aa)
PTGFRProstaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (365 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
DGKIDiacylglycerol kinase. (960 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1071 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (344 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (985 aa)
GNA13G protein subunit alpha 13. (306 aa)
RRASRAS related. (218 aa)
Pik3r2Uncharacterized protein. (724 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4. (378 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
SHC4SHC adaptor protein 4. (630 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
PDGFAPlatelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
TSC1TSC complex subunit 1. (1164 aa)
RHEBL1RHEB like 1. (183 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
RhoaRas homolog family member A. (193 aa)
CYTH1Cytohesin 1. (389 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ZNF408Zinc finger protein 408. (722 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (748 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
SYKTyrosine-protein kinase. (626 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
GRM8Glutamate metabotropic receptor 8. (908 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
FYNTyrosine-protein kinase. (537 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (869 aa)
PTK6Tyrosine-protein kinase. (450 aa)
MS4A2Membrane spanning 4-domains A2. (235 aa)
SRMSTyrosine-protein kinase. (534 aa)
GRM3Glutamate metabotropic receptor 3. (879 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
AVPR2Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (371 aa)
DGKKDiacylglycerol kinase. (1110 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
Arf1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
DGKHDiacylglycerol kinase. (1216 aa)
PLD1Phospholipase. (1037 aa)
AGPAT31-acylglycerol-3-phosphate O-acyltransferase 3. (376 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RalgdsUncharacterized protein. (894 aa)
DGKDDiacylglycerol kinase. (1170 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
SPHK2Sphingosine kinase 2. (655 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
GRM7Glutamate metabotropic receptor 7. (629 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TSC2TSC complex subunit 2. (1745 aa)
CXCR2C-X-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (359 aa)
CXCR1C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
I3MM52_ICTTRIg-like domain-containing protein. (222 aa)
PLA2G4EPhospholipase A2. (876 aa)
PLA2G4DPhospholipase A2. (827 aa)
PLA2G4FPhospholipase A2. (840 aa)
DGKQDiacylglycerol kinase. (924 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
PLD2Phospholipase. (933 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
I3MSG9_ICTTRIg-like domain-containing protein. (186 aa)
CYTH4Cytohesin 4. (367 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (418 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GAB1GRB2 associated binding protein 1. (724 aa)
GRM4Glutamate metabotropic receptor 4. (911 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (145 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (384 aa)
LOC101959358Uncharacterized protein. (193 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (319 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
GRM2Glutamate metabotropic receptor 2. (872 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (211 aa)
RUFY4RUN and FYVE domain containing 4. (566 aa)
RhocUncharacterized protein. (193 aa)
RRAS2RAS related 2. (173 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
LOC101960968Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
ERASES cell expressed Ras. (227 aa)
SPHK1Sphingosine kinase 1. (385 aa)
GNA12G protein subunit alpha 12. (343 aa)
LPAR1Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
JMJD7Jumonji domain containing 7. (316 aa)
GRM1Glutamate metabotropic receptor 1. (1131 aa)
RALARAS like proto-oncogene A. (206 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (452 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (218 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
GRM6Glutamate metabotropic receptor 6. (878 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1112 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (213 aa)
CEP152Centrosomal protein 152. (1507 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
GnasUncharacterized protein. (244 aa)
DGKGDiacylglycerol kinase. (791 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
LOC101967288Uncharacterized protein. (848 aa)
ENSSTOP00000027636Ig-like domain-containing protein. (165 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
ENSSTOP00000028111Ig-like domain-containing protein. (135 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (810 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
DGKBDiacylglycerol kinase. (802 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
LOC101962636Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (175 aa)
DGKADiacylglycerol kinase. (799 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
Csde1Uncharacterized protein. (555 aa)
Shc2Uncharacterized protein. (581 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PLA2G4APhospholipase A2. (750 aa)
DGKZDiacylglycerol kinase. (1154 aa)
GRM5Glutamate metabotropic receptor 5. (1178 aa)
CYTH3Cytohesin 3. (399 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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