STRINGSTRING
MRAS MRAS DAPK3 DAPK3 SQSTM1 SQSTM1 RUBCN RUBCN MAP3K7 MAP3K7 MTOR MTOR SH3GLB1 SH3GLB1 RPTOR RPTOR MTMR3 MTMR3 Csde1 Csde1 MAPK9 MAPK9 ENSSTOP00000030521 ENSSTOP00000030521 MLST8 MLST8 Pik3cd Pik3cd CAMKK2 CAMKK2 Pik3r3 Pik3r3 MTMR4 MTMR4 PRKACB PRKACB SNAP47 SNAP47 ENSSTOP00000028611 ENSSTOP00000028611 HRAS HRAS Supt20h Supt20h RAB33A RAB33A AKT1 AKT1 CRYBB3 CRYBB3 LOC101975023 LOC101975023 ENSSTOP00000027631 ENSSTOP00000027631 Ppp2cb Ppp2cb ITPR1 ITPR1 Hmgb1 Hmgb1 ENSSTOP00000026616 ENSSTOP00000026616 ENSSTOP00000026508 ENSSTOP00000026508 ATG7 ATG7 PIK3R1 PIK3R1 ATG16L1 ATG16L1 Rab1a Rab1a ATG13 ATG13 Becn1 Becn1 CFLAR CFLAR Bcl2l1 Bcl2l1 LOC101968118 LOC101968118 ULK2 ULK2 ATG4C ATG4C ENSSTOP00000024229 ENSSTOP00000024229 PRKAA1 PRKAA1 LMLN LMLN LOC101968945 LOC101968945 TSSK1B TSSK1B RAB7B RAB7B IRS4 IRS4 ATG14 ATG14 RIT2 RIT2 GABARAPL2 GABARAPL2 RAB7A RAB7A Atg9a Atg9a RAB8A RAB8A REM1 REM1 TSSK6 TSSK6 Hmgb3 Hmgb3 ERAS ERAS BECN2 BECN2 LOC101960423 LOC101960423 Rps6kb1 Rps6kb1 STK35 STK35 RIT1 RIT1 AMBRA1 AMBRA1 RRAS2 RRAS2 RAB43 RAB43 KIAA1671 KIAA1671 PRKCQ PRKCQ NOL4L NOL4L HMGB2 HMGB2 TSSK2 TSSK2 IRS1 IRS1 WDR41 WDR41 IFITM10 IFITM10 PPP1R14B PPP1R14B LOC101975126 LOC101975126 Ins Ins I3MXX5_ICTTR I3MXX5_ICTTR RPS6KB2 RPS6KB2 ATG4D ATG4D Prkx Prkx SMCR8 SMCR8 UVRAG UVRAG BCL2 BCL2 RAB33B RAB33B RASL11B RASL11B Igbp1 Igbp1 PTEN PTEN GABARAP GABARAP NRAS NRAS HIF3A HIF3A LOC101965906 LOC101965906 LAMP2 LAMP2 Ctsd Ctsd ATG5 ATG5 VMP1 VMP1 ATG2B ATG2B DAPK2 DAPK2 EIF2AK4 EIF2AK4 Ctsl Ctsl DAPK1 DAPK1 SNAP29 SNAP29 TP53INP2 TP53INP2 MAPK1 MAPK1 NPAS3 NPAS3 ATG4B ATG4B DEPTOR DEPTOR ATG3 ATG3 PIK3C3 PIK3C3 TSC2 TSC2 PDPK1 PDPK1 PIK3CA PIK3CA AKT1S1 AKT1S1 MAPK8 MAPK8 BNIP3 BNIP3 Ern2 Ern2 I3MJ28_ICTTR I3MJ28_ICTTR ZFYVE28 ZFYVE28 ATG12 ATG12 IGF1R IGF1R Nrbf2 Nrbf2 RAB39B RAB39B ULK1 ULK1 ZFYVE1 ZFYVE1 RRAGC RRAGC GEM GEM C9orf72 C9orf72 AKT3 AKT3 PPP2CA PPP2CA REM2 REM2 PRKAA2 PRKAA2 DDIT4L DDIT4L STX17 STX17 ATG2A ATG2A LOC101962660 LOC101962660 EIF2AK3 EIF2AK3 KRAS KRAS MAP2K1 MAP2K1 ERN1 ERN1 BAD BAD TBK1 TBK1 RRAD RRAD CTSV CTSV TANK TANK TRAF6 TRAF6 RRAGD RRAGD LOC101966186 LOC101966186 TSSK3 TSSK3 VAMP8 VAMP8 ATG10 ATG10 PDIK1L PDIK1L Hif1a Hif1a RRAGB RRAGB PRKCD PRKCD RHEB RHEB CRYGN CRYGN TP53INP1 TP53INP1 RASEF RASEF RHEBL1 RHEBL1 LAMP1 LAMP1 TTC14 TTC14 ATG16L2 ATG16L2 ATG4A ATG4A TSC1 TSC1 NPAS1 NPAS1 RAB39A RAB39A WIPI1 WIPI1 RB1CC1 RB1CC1 AKT2 AKT2 NOL4 NOL4 STK11 STK11 Map2k2 Map2k2 PRKACA PRKACA TSSK4 TSSK4 GABARAPL1 GABARAPL1 DUS2 DUS2 MTMR14 MTMR14 Pik3r2 Pik3r2 RRAS RRAS MAPK10 MAPK10 EIF2S1 EIF2S1 WIPI2 WIPI2 PIK3CB PIK3CB KCNK1 KCNK1 PIK3R4 PIK3R4 Prap1 Prap1 ATG9B ATG9B MAPK3 MAPK3 DDIT4 DDIT4 ATG101 ATG101
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRASMuscle RAS oncogene homolog. (208 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
SQSTM1Sequestosome 1. (440 aa)
RUBCNRubicon autophagy regulator. (973 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (387 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
MTMR3Myotubularin related protein 3. (1006 aa)
Csde1Uncharacterized protein. (555 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000030521Uncharacterized protein. (164 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
Pik3r3Uncharacterized protein. (461 aa)
MTMR4Myotubularin related protein 4. (1208 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
SNAP47Synaptosome associated protein 47. (447 aa)
ENSSTOP00000028611Uncharacterized protein. (195 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
Supt20hUncharacterized protein. (200 aa)
RAB33ARAB33A, member RAS oncogene family. (237 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CRYBB3Crystallin beta B3; Belongs to the beta/gamma-crystallin family. (211 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
Hmgb1Uncharacterized protein. (188 aa)
ENSSTOP00000026616Uncharacterized protein. (174 aa)
ENSSTOP00000026508BH4_2 domain-containing protein. (224 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (726 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ATG16L1Autophagy related 16 like 1. (624 aa)
Rab1aUncharacterized protein. (205 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
Becn1Beclin 1. (448 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
Bcl2l1BH4_2 domain-containing protein. (233 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1058 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (473 aa)
ENSSTOP00000024229Uncharacterized protein. (169 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
LMLNLeishmanolysin-like peptidase. (684 aa)
LOC101968945Uncharacterized protein; Belongs to the peptidase C1 family. (339 aa)
TSSK1BTestis specific serine kinase 1B; Belongs to the protein kinase superfamily. (369 aa)
RAB7BRAB7B, member RAS oncogene family. (184 aa)
IRS4Insulin receptor substrate 4. (1228 aa)
ATG14Autophagy related 14. (492 aa)
RIT2Ras like without CAAX 2. (217 aa)
GABARAPL2GABA type A receptor associated protein like 2. (123 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
Atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (309 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
Hmgb3High mobility group box 3. (200 aa)
ERASES cell expressed Ras. (227 aa)
BECN2Beclin 2. (412 aa)
LOC101960423Protein kinase domain-containing protein. (473 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
STK35Serine/threonine kinase 35. (539 aa)
RIT1Ras like without CAAX 1. (219 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1240 aa)
RRAS2RAS related 2. (173 aa)
RAB43RAB43, member RAS oncogene family. (144 aa)
KIAA1671KIAA1671. (1773 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
NOL4LNucleolar protein 4 like. (573 aa)
HMGB2High mobility group box 2. (210 aa)
TSSK2Testis specific serine kinase 2; Belongs to the protein kinase superfamily. (358 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
WDR41WD repeat domain 41. (461 aa)
IFITM10Interferon induced transmembrane protein 10. (200 aa)
PPP1R14BProtein phosphatase 1 regulatory inhibitor subunit 14B. (145 aa)
LOC101975126Uncharacterized protein. (498 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
I3MXX5_ICTTRUncharacterized protein. (257 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
ATG4DCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (474 aa)
PrkxUncharacterized protein. (330 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
UVRAGUV radiation resistance associated. (698 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
RASL11BRAS like family 11 member B. (248 aa)
Igbp1Uncharacterized protein. (341 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (677 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
LAMP2Lysosomal associated membrane protein 2. (458 aa)
CtsdPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (411 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
VMP1Vacuole membrane protein 1. (406 aa)
ATG2BAutophagy related 2B. (2015 aa)
DAPK2Death associated protein kinase 2; Belongs to the protein kinase superfamily. (376 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1631 aa)
CtslUncharacterized protein; Belongs to the peptidase C1 family. (333 aa)
DAPK1Death associated protein kinase 1. (1432 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
NPAS3Neuronal PAS domain protein 3. (926 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (393 aa)
DEPTORDEP domain containing MTOR interacting protein. (409 aa)
ATG3Autophagy-related protein 3. (314 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (783 aa)
TSC2TSC complex subunit 2. (1745 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AKT1S1AKT1 substrate 1. (274 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BNIP3BCL2 interacting protein 3. (217 aa)
Ern2Endoplasmic reticulum to nucleus signaling 2. (916 aa)
I3MJ28_ICTTRUncharacterized protein. (195 aa)
ZFYVE28Zinc finger FYVE-type containing 28. (910 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
Nrbf2Uncharacterized protein. (287 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
ZFYVE1Zinc finger FYVE-type containing 1. (777 aa)
RRAGCRas related GTP binding C. (320 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
DDIT4LDNA damage inducible transcript 4 like. (192 aa)
STX17Syntaxin 17; Belongs to the syntaxin family. (302 aa)
ATG2AAutophagy related 2A. (1911 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (1005 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (972 aa)
BADBCL2 associated agonist of cell death. (208 aa)
TBK1TANK binding kinase 1. (729 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (332 aa)
TANKTRAF family member associated NFKB activator. (439 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
RRAGDRas related GTP binding D. (399 aa)
LOC101966186Uncharacterized protein. (159 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
VAMP8Vesicle associated membrane protein 8. (141 aa)
ATG10Autophagy related 10. (220 aa)
PDIK1LPDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. (402 aa)
Hif1aUncharacterized protein. (821 aa)
RRAGBRas related GTP binding B. (374 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (147 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
RASEFRAS and EF-hand domain containing. (738 aa)
RHEBL1RHEB like 1. (183 aa)
LAMP1Lysosomal associated membrane protein 1. (389 aa)
TTC14Tetratricopeptide repeat domain 14. (759 aa)
ATG16L2Autophagy related 16 like 2. (620 aa)
ATG4ACysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (398 aa)
TSC1TSC complex subunit 1. (1164 aa)
NPAS1Neuronal PAS domain protein 1. (592 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (422 aa)
RB1CC1RB1 inducible coiled-coil 1. (1593 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
NOL4Nucleolar protein 4. (638 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
TSSK4Testis specific serine kinase 4. (292 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
MTMR14Myotubularin related protein 14. (643 aa)
Pik3r2Uncharacterized protein. (724 aa)
RRASRAS related. (218 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
WIPI2WD repeat domain, phosphoinositide interacting 2. (445 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KCNK1Potassium channel subfamily K member. (335 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1305 aa)
Prap1Uncharacterized protein. (145 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (920 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
DDIT4DNA damage inducible transcript 4. (228 aa)
ATG101Autophagy related 101. (218 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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