STRINGSTRING
LOC101965906 LOC101965906 CCND1 CCND1 INSR INSR PPP2R1A PPP2R1A PIK3CB PIK3CB Pik3r2 Pik3r2 PFKM PFKM ACACA ACACA STK11 STK11 AKT2 AKT2 CAB39L CAB39L TSC1 TSC1 CCNA1 CCNA1 RHEBL1 RHEBL1 LOC101966452 LOC101966452 RHEB RHEB ACACB ACACB EEF2 EEF2 CREB3 CREB3 I3M6L1_ICTTR I3M6L1_ICTTR LOC101964310 LOC101964310 PFKP PFKP GYS2 GYS2 PRKAG3 PRKAG3 SCD5 SCD5 Eif4ebp1 Eif4ebp1 NOSTRIN NOSTRIN G6PC3 G6PC3 G6PC2 G6PC2 PCK2 PCK2 CCNA2 CCNA2 SLC2A4 SLC2A4 PRKAB1 PRKAB1 ELAVL1 ELAVL1 PPP2R3C PPP2R3C HMGCR HMGCR Foxo1 Foxo1 LOC101962660 LOC101962660 CREB3L2 CREB3L2 PFKFB4 PFKFB4 FASN FASN PRKAA2 PRKAA2 PPP2CA PPP2CA AKT3 AKT3 ULK1 ULK1 IGF1R IGF1R Lipe Lipe PPP2R2D PPP2R2D LOC101965270 LOC101965270 CREB3L1 CREB3L1 PPARG PPARG AKT1S1 AKT1S1 CPT1A CPT1A PIK3CA PIK3CA PDPK1 PDPK1 TSC2 TSC2 PPP2R5A PPP2R5A CPT1B CPT1B GYS1 GYS1 CREB3L4 CREB3L4 PRKAG1 PRKAG1 PPP2R3A PPP2R3A PCK1 PCK1 ADIPOR1 ADIPOR1 ADIPOQ ADIPOQ PFKFB1 PFKFB1 CREB1 CREB1 CREB3L3 CREB3L3 LEP LEP SIRT1 SIRT1 G6PC G6PC PPP2R5E PPP2R5E RPS6KB2 RPS6KB2 RAB10 RAB10 Ins Ins ADRA1A ADRA1A I3MY97_ICTTR I3MY97_ICTTR LOC101975126 LOC101975126 CAB39 CAB39 Tbc1d1 Tbc1d1 PPP2R2A PPP2R2A IRS1 IRS1 FBP2 FBP2 FBP1 FBP1 ADIPOR2 ADIPOR2 RAB2A RAB2A LEPR LEPR PPP2R5D PPP2R5D Rps6kb1 Rps6kb1 PPP2R5B PPP2R5B RAB14 RAB14 RAB8A RAB8A Foxo3 Foxo3 GAREM2 GAREM2 PFKL PFKL IRS4 IRS4 STRADB STRADB CRTC2 CRTC2 PRKAA1 PRKAA1 PFKFB3 PFKFB3 ENSSTOP00000024432 ENSSTOP00000024432 LOC101968118 LOC101968118 CPT1C CPT1C CD36 CD36 PIK3R1 PIK3R1 PPARGC1A PPARGC1A PPP2R1B PPP2R1B LOC101965950 LOC101965950 CREB5 CREB5 PRKAG2 PRKAG2 HNF4A HNF4A STRADA STRADA Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 RAB11B RAB11B ENSSTOP00000028389 ENSSTOP00000028389 PPP2R5C PPP2R5C AKT1 AKT1 ENSSTOP00000029088 ENSSTOP00000029088 Pik3r3 Pik3r3 SREBF1 SREBF1 CAMKK2 CAMKK2 PPP2R2C PPP2R2C Pik3cd Pik3cd IGF1 IGF1 EEF2K EEF2K PFKFB2 PFKFB2 PPP2R2B PPP2R2B PRKAB2 PRKAB2 RPTOR RPTOR RAB2B RAB2B MTOR MTOR ENSSTOP00000032383 ENSSTOP00000032383 MAP3K7 MAP3K7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CCND1Cyclin D1. (250 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Pik3r2Uncharacterized protein. (724 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
ACACAAcetyl-CoA carboxylase alpha. (2383 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (437 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
CAB39LCalcium binding protein 39 like. (315 aa)
TSC1TSC complex subunit 1. (1164 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
RHEBL1RHEB like 1. (183 aa)
LOC101966452FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (349 aa)
RHEBRas homolog, mTORC1 binding. (184 aa)
ACACBAcetyl-CoA carboxylase beta. (2328 aa)
EEF2Eukaryotic translation elongation factor 2. (857 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
I3M6L1_ICTTRABC transmembrane type-1 domain-containing protein. (528 aa)
LOC101964310FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (354 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
SCD5Stearoyl-CoA desaturase 5; Belongs to the fatty acid desaturase type 1 family. (330 aa)
Eif4ebp1Uncharacterized protein. (118 aa)
NOSTRINNitric oxide synthase trafficking. (505 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (420 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4. (469 aa)
FASNFatty acid synthase. (2467 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1041 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
LipeHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (439 aa)
LOC101965270FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (360 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
AKT1S1AKT1 substrate 1. (274 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
TSC2TSC complex subunit 2. (1745 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (649 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1149 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
ADIPOR1Uncharacterized protein. (375 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (471 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
SIRT1Sirtuin 1. (602 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
RAB10RAB10, member RAS oncogene family. (200 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
I3MY97_ICTTRUncharacterized protein. (155 aa)
LOC101975126Uncharacterized protein. (498 aa)
CAB39Calcium binding protein 39. (341 aa)
Tbc1d1Uncharacterized protein. (1233 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
FBP2Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (339 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
RAB2ARAB2A, member RAS oncogene family. (196 aa)
LEPRLeptin receptor. (1148 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
Foxo3Forkhead box O3. (673 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (863 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
IRS4Insulin receptor substrate 4. (1228 aa)
STRADBSTE20 related adaptor beta. (418 aa)
CRTC2CREB regulated transcription coactivator 2. (693 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (544 aa)
ENSSTOP00000024432MCD domain-containing protein. (267 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
CPT1CCarnitine palmitoyltransferase 1C. (834 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
LOC101965950FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (357 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
STRADASTE20 related adaptor alpha. (431 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
ENSSTOP00000028389Uncharacterized protein. (113 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSSTOP00000029088Rab-GAP TBC domain-containing protein. (355 aa)
Pik3r3Uncharacterized protein. (461 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (587 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
IGF1Insulin like growth factor 1. (166 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (556 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
RAB2BRAB2B, member RAS oncogene family. (216 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
ENSSTOP00000032383Uncharacterized protein. (131 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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