STRINGSTRING
RPTOR RPTOR ADCY5 ADCY5 INSR INSR KCNK1 KCNK1 PIK3CB PIK3CB Pik3r2 Pik3r2 PRKACA PRKACA ADCY4 ADCY4 AKT2 AKT2 HSPA8 HSPA8 ADCY6 ADCY6 SOD1 SOD1 TIMM8A TIMM8A CLPB CLPB ADCY2 ADCY2 ADCY9 ADCY9 PTRHD1 PTRHD1 ADCY3 ADCY3 PRKAG3 PRKAG3 CAT CAT PRKAB1 PRKAB1 Sod2 Sod2 ADCY1 ADCY1 KRAS KRAS Foxo1 Foxo1 LOC101962660 LOC101962660 CRYAB CRYAB PRKAA2 PRKAA2 AKT3 AKT3 IGF1R IGF1R Hdac1 Hdac1 HDAC2 HDAC2 AKT1S1 AKT1S1 PIK3CA PIK3CA EIF4EBP2 EIF4EBP2 Hspa1a Hspa1a PRKAG1 PRKAG1 ATG5 ATG5 TIMM8B TIMM8B LOC101965906 LOC101965906 FOXA1 FOXA1 SIRT1 SIRT1 NRAS NRAS RPS6KB2 RPS6KB2 Ins Ins LOC101975126 LOC101975126 IRS1 IRS1 Hspa1b Hspa1b HSPA1L HSPA1L FOXA2 FOXA2 Rps6kb1 Rps6kb1 ERAS ERAS I3NAI6_ICTTR I3NAI6_ICTTR Foxo3 Foxo3 HSPA6 HSPA6 IRS4 IRS4 PRKAA1 PRKAA1 ENSSTOP00000024144 ENSSTOP00000024144 LOC101968118 LOC101968118 PIK3R1 PIK3R1 ENSSTOP00000026639 ENSSTOP00000026639 PRKAG2 PRKAG2 LOC101975023 LOC101975023 AKT1 AKT1 HRAS HRAS ADCY7 ADCY7 PRKACB PRKACB MTOR MTOR Pik3r3 Pik3r3 Pik3cd Pik3cd IGF1 IGF1 ADCY8 ADCY8 PRKAB2 PRKAB2 Csde1 Csde1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
KCNK1Potassium channel subfamily K member. (335 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Pik3r2Uncharacterized protein. (724 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
HSPA8Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
TIMM8ATranslocase of inner mitochondrial membrane 8A; Belongs to the small Tim family. (97 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (708 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
Sod2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
Hdac1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (399 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
AKT1S1AKT1 substrate 1. (274 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (120 aa)
Hspa1aUncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (83 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
FOXA1Forkhead box A1. (468 aa)
SIRT1Sirtuin 1. (602 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC101975126Uncharacterized protein. (498 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
Hspa1bHeat shock protein family A (Hsp70) member 1B. (641 aa)
HSPA1LHeat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
FOXA2Forkhead box A2. (463 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ERASES cell expressed Ras. (227 aa)
I3NAI6_ICTTRzf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (97 aa)
Foxo3Forkhead box O3. (673 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
IRS4Insulin receptor substrate 4. (1228 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
ENSSTOP00000024144zf-Tim10_DDP domain-containing protein; Belongs to the small Tim family. (87 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSSTOP00000026639Hist_deacetyl domain-containing protein. (323 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
IGF1Insulin like growth factor 1. (166 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
Csde1Uncharacterized protein. (555 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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