STRINGSTRING
I3NBU5_ICTTR I3NBU5_ICTTR TRPM7 TRPM7 CAMK2B CAMK2B IFNGR2 IFNGR2 Pla2g4b Pla2g4b PLA2G4C PLA2G4C RIPK1 RIPK1 PPID PPID MAPK10 MAPK10 Rnf31 Rnf31 IL1A IL1A IL1B IL1B RIPK3 RIPK3 SHARPIN SHARPIN TYK2 TYK2 CAPN11 CAPN11 I3M249_ICTTR I3M249_ICTTR CAPN9 CAPN9 XIAP XIAP PGPEP1 PGPEP1 XKRX XKRX CHMP4B CHMP4B USP2 USP2 BIRC3 BIRC3 Birc2 Birc2 VDAC3 VDAC3 TNFSF10 TNFSF10 USP21 USP21 JAK2 JAK2 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 LOC101966186 LOC101966186 H2AC12 H2AC12 SUCO SUCO Faslg Faslg VDAC1 VDAC1 JAK3 JAK3 TNFAIP3 TNFAIP3 AIFM1 AIFM1 STAT1 STAT1 SNTB1 SNTB1 CAMK2A CAMK2A SMPD1 SMPD1 CAPN2 CAPN2 HSP90AA1 HSP90AA1 TNFRSF1A TNFRSF1A CYLD CYLD RFWD3 RFWD3 Ppia Ppia NLRP3 NLRP3 CAPN8 CAPN8 H2AC6 H2AC6 CASP8 CASP8 TRADD TRADD CHMP2B CHMP2B Slc25a6 Slc25a6 DNM1L DNM1L PYGL PYGL TRAF2 TRAF2 I3MJ28_ICTTR I3MJ28_ICTTR MAPK8 MAPK8 MACROH2A2 MACROH2A2 LOC101970492 LOC101970492 Glud1 Glud1 SNTB2 SNTB2 Vps4a Vps4a TNF TNF CHMP4C CHMP4C STAT6 STAT6 PYCARD PYCARD EIF2AK2 EIF2AK2 BAX BAX PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F PYGB PYGB H2AX H2AX GLUL GLUL MACROH2A1 MACROH2A1 IFNG IFNG IFNAR1 IFNAR1 CHMP7 CHMP7 I3MQN1_ICTTR I3MQN1_ICTTR STAT2 STAT2 PARP1 PARP1 CRACR2B CRACR2B MDP1 MDP1 LOC101973285 LOC101973285 H2AC11 H2AC11 Ftl Ftl SNTA1 SNTA1 H1-2 H1-2 BCL2 BCL2 SPATA2 SPATA2 STAT4 STAT4 RNF103 RNF103 RBCK1 RBCK1 H2AW H2AW IFNGR1 IFNGR1 H2AC21 H2AC21 LOC101977597 LOC101977597 TLR4 TLR4 LOC101959922 LOC101959922 HMGB2 HMGB2 ARSI ARSI BID BID LOC101967565 LOC101967565 SLC25A4 SLC25A4 CHMP6 CHMP6 CAPN3 CAPN3 ALOX15 ALOX15 IRF9 IRF9 JAK1 JAK1 VPS4B VPS4B Chmp3 Chmp3 LOC101968765 LOC101968765 I3N7H2_ICTTR I3N7H2_ICTTR CRACR2A CRACR2A Chmp5 Chmp5 TICAM2 TICAM2 Hmgb3 Hmgb3 LOC101966441 LOC101966441 CAPN14 CAPN14 CASP10 CASP10 CHMP1A CHMP1A HSP90AB1 HSP90AB1 LOC101955430 LOC101955430 JMJD7 JMJD7 TLR3 TLR3 Rab44 Rab44 CAMK2D CAMK2D CAPN12 CAPN12 CYBB CYBB I3NEB6_ICTTR I3NEB6_ICTTR SPATA2L SPATA2L Chmp2a Chmp2a LOC101975245 LOC101975245 H2AC20 H2AC20 H1-5 H1-5 Slc25a5 Slc25a5 I3NHU4_ICTTR I3NHU4_ICTTR TMED3 TMED3 ENSSTOP00000023977 ENSSTOP00000023977 CAMK2G CAMK2G ENSSTOP00000024522 ENSSTOP00000024522 PYGM PYGM FADD FADD CFLAR CFLAR IL33 IL33 ENSSTOP00000025352 ENSSTOP00000025352 ENSSTOP00000025775 ENSSTOP00000025775 MLKL MLKL TRAF5 TRAF5 ENSSTOP00000026616 ENSSTOP00000026616 LOC101969049 LOC101969049 LGSN LGSN Hmgb1 Hmgb1 ENSSTOP00000027807 ENSSTOP00000027807 H2AZ2 H2AZ2 CHMP4A CHMP4A ENSSTOP00000028611 ENSSTOP00000028611 H2AJ H2AJ ENSSTOP00000028786 ENSSTOP00000028786 Tmed7 Tmed7 ENSSTOP00000028887 ENSSTOP00000028887 ENSSTOP00000028908 ENSSTOP00000028908 LOC101974663 LOC101974663 CAPN1 CAPN1 VDAC2 VDAC2 ENSSTOP00000030003 ENSSTOP00000030003 FAF1 FAF1 MAPK9 MAPK9 ENSSTOP00000030705 ENSSTOP00000030705 PLA2G4A PLA2G4A Ifnar2 Ifnar2 PELP1 PELP1 ENSSTOP00000031908 ENSSTOP00000031908 LOC101967165 LOC101967165 SQSTM1 SQSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I3NBU5_ICTTRUncharacterized protein. (209 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1727 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
IFNGR2Interferon gamma receptor 2. (306 aa)
Pla2g4bPhospholipase A2. (774 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
PPIDPeptidylprolyl isomerase D. (370 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Rnf31Uncharacterized protein. (1071 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
SHARPINSHANK associated RH domain interactor. (382 aa)
TYK2Tyrosine-protein kinase. (1194 aa)
CAPN11Calpain 11; Belongs to the peptidase C2 family. (700 aa)
I3M249_ICTTRUncharacterized protein. (683 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (690 aa)
XIAPX-linked inhibitor of apoptosis. (497 aa)
PGPEP1Pyroglutamyl-peptidase I. (209 aa)
XKRXXK-related protein. (449 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (612 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
Birc2Uncharacterized protein. (611 aa)
VDAC3Voltage dependent anion channel 3. (284 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (296 aa)
USP21Ubiquitin specific peptidase 21; Belongs to the peptidase C19 family. (567 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
LOC101966186Uncharacterized protein. (159 aa)
H2AC12Histone H2A; Belongs to the histone H2A family. (128 aa)
SUCOSUN domain containing ossification factor. (1253 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
VDAC1Voltage dependent anion channel 1. (292 aa)
JAK3Tyrosine-protein kinase. (1042 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
SNTB1Syntrophin beta 1. (538 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
CAPN2Calpain 2; Belongs to the peptidase C2 family. (700 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
RFWD3Ring finger and WD repeat domain 3. (808 aa)
PpiaPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
CAPN8Calpain 8; Belongs to the peptidase C2 family. (703 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
TRADDTNFRSF1A associated via death domain. (302 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
Slc25a6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
I3MJ28_ICTTRUncharacterized protein. (195 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MACROH2A2Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa)
LOC101970492Histone H2A; Belongs to the histone H2A family. (131 aa)
Glud1ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (264 aa)
SNTB2Syntrophin beta 2. (436 aa)
Vps4aUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
PYCARDPYD and CARD domain containing. (194 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (538 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PLA2G4EPhospholipase A2. (876 aa)
PLA2G4DPhospholipase A2. (827 aa)
PLA2G4FPhospholipase A2. (840 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
GLULGlutamine synthetase. (373 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (490 aa)
CHMP7Charged multivesicular body protein 7. (445 aa)
I3MQN1_ICTTRUncharacterized protein. (140 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
CRACR2BCalcium release activated channel regulator 2B. (397 aa)
MDP1Uncharacterized protein. (164 aa)
LOC101973285Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC11Histone H2A type 1. (130 aa)
FtlFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (222 aa)
SNTA1Syntrophin alpha 1. (453 aa)
H1-2Histone cluster 1 H1 family member c. (212 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
SPATA2Spermatogenesis associated 2. (509 aa)
STAT4Signal transducer and activator of transcription. (758 aa)
RNF103Ring finger protein 103. (670 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (536 aa)
H2AWHistone H2A; Belongs to the histone H2A family. (130 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC101977597Histone H2A; Belongs to the histone H2A family. (130 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
LOC101959922Uncharacterized protein. (442 aa)
HMGB2High mobility group box 2. (210 aa)
ARSIArylsulfatase family member I. (572 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (195 aa)
LOC101967565Histone H2A; Belongs to the histone H2A family. (116 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
IRF9Interferon regulatory factor 9. (357 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
VPS4BVacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (444 aa)
Chmp3Uncharacterized protein. (208 aa)
LOC101968765Uncharacterized protein. (187 aa)
I3N7H2_ICTTRHistone H2A; Belongs to the histone H2A family. (120 aa)
CRACR2ACalcium release activated channel regulator 2A. (730 aa)
Chmp5Uncharacterized protein. (219 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
Hmgb3High mobility group box 3. (200 aa)
LOC101966441Histone H2A; Belongs to the histone H2A family. (130 aa)
CAPN14Calpain 14; Belongs to the peptidase C2 family. (674 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
CHMP1ACharged multivesicular body protein 1A. (196 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (724 aa)
LOC101955430Histone H2A type 1. (130 aa)
JMJD7Jumonji domain containing 7. (316 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
Rab44Uncharacterized protein. (645 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
CAPN12Calpain 12; Belongs to the peptidase C2 family. (645 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
I3NEB6_ICTTRPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (148 aa)
SPATA2LSpermatogenesis associated 2 like. (425 aa)
Chmp2aUncharacterized protein. (222 aa)
LOC101975245HATPase_c domain-containing protein. (733 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
H1-5Histone cluster 1 H1 family member b. (226 aa)
Slc25a5Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
I3NHU4_ICTTRFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (172 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
ENSSTOP00000023977Uncharacterized protein. (205 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
ENSSTOP00000024522Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (186 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
IL33Interleukin 33. (264 aa)
ENSSTOP00000025352Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (147 aa)
ENSSTOP00000025775Uncharacterized protein. (710 aa)
MLKLMixed lineage kinase domain like pseudokinase. (472 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENSSTOP00000026616Uncharacterized protein. (174 aa)
LOC101969049Uncharacterized protein. (174 aa)
LGSNLengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (572 aa)
Hmgb1Uncharacterized protein. (188 aa)
ENSSTOP00000027807Uncharacterized protein. (160 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
CHMP4ACharged multivesicular body protein 4A. (259 aa)
ENSSTOP00000028611Uncharacterized protein. (195 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (140 aa)
ENSSTOP00000028786Ferritin domain-containing protein. (190 aa)
Tmed7GOLD domain-containing protein. (225 aa)
ENSSTOP00000028887Uncharacterized protein. (184 aa)
ENSSTOP00000028908Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (253 aa)
LOC101974663Histone H2A; Belongs to the histone H2A family. (149 aa)
CAPN1Calpain 1; Belongs to the peptidase C2 family. (743 aa)
VDAC2Voltage dependent anion channel 2. (294 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
FAF1Fas associated factor 1. (673 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000030705Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (267 aa)
PLA2G4APhospholipase A2. (750 aa)
Ifnar2Uncharacterized protein. (516 aa)
PELP1Proline, glutamate and leucine rich protein 1. (1152 aa)
ENSSTOP00000031908Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (180 aa)
LOC101967165Histone H2A; Belongs to the histone H2A family. (144 aa)
SQSTM1Sequestosome 1. (440 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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