STRINGSTRING
LOC101978636 LOC101978636 ADCY5 ADCY5 MYLK MYLK EDN1 EDN1 PROCA1 PROCA1 Pla2g4b Pla2g4b ERF ERF MAPK3 MAPK3 PLA2G4C PLA2G4C CYP4B1 CYP4B1 MYL9 MYL9 GNA13 GNA13 PLA2G3 PLA2G3 PRKACA PRKACA Map2k2 Map2k2 ADCY4 ADCY4 BRAF BRAF Kcnmb2 Kcnmb2 CALCRL CALCRL PRKCA PRKCA ARHGEF1 ARHGEF1 MYLK3 MYLK3 CALCA CALCA ARAF ARAF ADCY6 ADCY6 ADORA2B ADORA2B PLA2G1B PLA2G1B Rhoa Rhoa PRKCD PRKCD ADCY2 ADCY2 ADCY9 ADCY9 PTRHD1 PTRHD1 ADCY3 ADCY3 I3M8I4_ICTTR I3M8I4_ICTTR NPR2 NPR2 LOC101964576 LOC101964576 PLA2G12A PLA2G12A PLA2G10 PLA2G10 I3MA50_ICTTR I3MA50_ICTTR PLA2G12B PLA2G12B MYLK2 MYLK2 CALML3 CALML3 PPP1R12C PPP1R12C ADCY1 ADCY1 MAP2K1 MAP2K1 PLA2G2D PLA2G2D PPP1CC PPP1CC Prkch Prkch I3MEF2_ICTTR I3MEF2_ICTTR PPP1R12B PPP1R12B EFCAB3 EFCAB3 PPP1R12A PPP1R12A CALCB CALCB PRKCB PRKCB PLA2G2E PLA2G2E ESYT3 ESYT3 EDN3 EDN3 PRKCE PRKCE GUCY1A2 GUCY1A2 LOC101977410 LOC101977410 LYVE1 LYVE1 MRVI1 MRVI1 KCNMB3 KCNMB3 PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F ACTG2 ACTG2 MAPK1 MAPK1 CACNA1C CACNA1C EDN2 EDN2 CALML4 CALML4 ACTA2 ACTA2 ARHGEF12 ARHGEF12 PLCB1 PLCB1 CALM1 CALM1 MYH11 MYH11 ADRA1D ADRA1D AVPR1A AVPR1A ADRA1B ADRA1B GNAQ GNAQ NPPB NPPB KCNMB1 KCNMB1 CALML6 CALML6 CACNA1F CACNA1F CALD1 CALD1 AGT AGT AGTR1 AGTR1 AVP AVP LOC101971249 LOC101971249 ADRA1A ADRA1A AVPR1B AVPR1B PPP1CB PPP1CB PPP1R14A PPP1R14A ETV3 ETV3 PTGIR PTGIR MYH9 MYH9 KCNU1 KCNU1 ADORA2A ADORA2A LOC101959358 LOC101959358 PRKCQ PRKCQ NPPC NPPC MYL6 MYL6 MYLK4 MYLK4 PLA2G2A PLA2G2A RAF1 RAF1 ROCK1 ROCK1 NPR1 NPR1 Rhoc Rhoc GNA11 GNA11 EDNRA EDNRA RAMP3 RAMP3 GNA12 GNA12 JMJD7 JMJD7 ARHGEF11 ARHGEF11 CALM2 CALM2 KCNMB4 KCNMB4 MYH14 MYH14 LOC101955536 LOC101955536 PLA2G2F PLA2G2F RAMP2 RAMP2 ESYT2 ESYT2 ITPR2 ITPR2 PLCB4 PLCB4 KCNMA1 KCNMA1 MYH10 MYH10 ITPR3 ITPR3 MYL6B MYL6B PRKCG PRKCG ESYT1 ESYT1 PPP1CA PPP1CA Gnas Gnas ADM ADM CALM3 CALM3 PLA2G5 PLA2G5 ITPR1 ITPR1 PLCB2 PLCB2 LOC101967288 LOC101967288 RAMP1 RAMP1 CACNA1S CACNA1S ADCY7 ADCY7 PRKACB PRKACB ENSSTOP00000029069 ENSSTOP00000029069 GUCY1A1 GUCY1A1 PRKG1 PRKG1 CACNA1D CACNA1D GUCY1B1 GUCY1B1 ENSSTOP00000029937 ENSSTOP00000029937 ENSSTOP00000030497 ENSSTOP00000030497 ADCY8 ADCY8 PLCB3 PLCB3 ENSSTOP00000030720 ENSSTOP00000030720 ENSSTOP00000031001 ENSSTOP00000031001 PLA2G4A PLA2G4A PLA2G6 PLA2G6 ENSSTOP00000032237 ENSSTOP00000032237 ENSSTOP00000032372 ENSSTOP00000032372 ROCK2 ROCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101978636Uncharacterized protein; Belongs to the cytochrome P450 family. (525 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
MYLKMyosin light chain kinase. (1897 aa)
EDN1Endothelin 1. (202 aa)
PROCA1Protein interacting with cyclin A1. (374 aa)
Pla2g4bPhospholipase A2. (774 aa)
ERFETS2 repressor factor. (552 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (459 aa)
MYL9Myosin light chain 9. (172 aa)
GNA13G protein subunit alpha 13. (306 aa)
PLA2G3Phospholipase A2 group III. (626 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
Kcnmb2KcnmB2_inactiv domain-containing protein. (235 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (972 aa)
MYLK3Myosin light chain kinase 3. (813 aa)
CALCACalcitonin related polypeptide alpha. (137 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
PLA2G1BPhospholipase A(2). (117 aa)
RhoaRas homolog family member A. (193 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
I3M8I4_ICTTRUncharacterized protein. (917 aa)
NPR2Guanylate cyclase. (1047 aa)
LOC101964576Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (734 aa)
PLA2G12APhospholipase A2 group XIIA. (189 aa)
PLA2G10Phospholipase A(2). (148 aa)
I3MA50_ICTTRUncharacterized protein. (220 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
PPP1R12CProtein phosphatase 1 regulatory subunit 12C. (558 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
PLA2G2DPhospholipase A(2). (145 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PrkchProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
I3MEF2_ICTTRETS domain-containing protein. (135 aa)
PPP1R12BProtein phosphatase 1 regulatory subunit. (994 aa)
EFCAB3EF-hand calcium binding domain 3. (432 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (1005 aa)
CALCBCalcitonin related polypeptide beta. (125 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
PLA2G2EPhospholipase A(2). (142 aa)
ESYT3Extended synaptotagmin 3. (888 aa)
EDN3Endothelin 3. (197 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (631 aa)
LOC101977410Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (318 aa)
MRVI1Murine retrovirus integration site 1 homolog. (901 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (243 aa)
PLA2G4EPhospholipase A2. (876 aa)
PLA2G4DPhospholipase A2. (827 aa)
PLA2G4FPhospholipase A2. (840 aa)
ACTG2Actin gamma 2, smooth muscle. (376 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
EDN2Endothelin 2. (148 aa)
CALML4Calmodulin like 4. (153 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1518 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
ADRA1DAdrenoceptor alpha 1D. (551 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (418 aa)
ADRA1BAdrenoceptor alpha 1B. (515 aa)
GNAQG protein subunit alpha q. (313 aa)
NPPBUncharacterized protein. (132 aa)
KCNMB1Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
CALML6Calmodulin like 6. (172 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1981 aa)
CALD1Caldesmon 1. (771 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (145 aa)
LOC101971249Uncharacterized protein. (298 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
PPP1R14AProtein phosphatase 1 regulatory inhibitor subunit 14A. (132 aa)
ETV3ETS variant 3. (510 aa)
PTGIRProstaglandin I2 receptor; Belongs to the G-protein coupled receptor 1 family. (406 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
KCNU1Potassium calcium-activated channel subfamily U member 1. (950 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (417 aa)
LOC101959358Uncharacterized protein. (193 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
NPPCNatriuretic peptide C. (126 aa)
MYL6Uncharacterized protein. (160 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (378 aa)
PLA2G2APhospholipase A(2). (145 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
NPR1Guanylate cyclase. (1037 aa)
RhocUncharacterized protein. (193 aa)
GNA11G protein subunit alpha 11. (359 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
RAMP3Receptor activity modifying protein 3. (147 aa)
GNA12G protein subunit alpha 12. (343 aa)
JMJD7Jumonji domain containing 7. (316 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1494 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
MYH14Myosin heavy chain 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1807 aa)
LOC101955536Uncharacterized protein. (346 aa)
PLA2G2FPhospholipase A(2). (209 aa)
RAMP2Receptor activity modifying protein 2. (177 aa)
ESYT2Extended synaptotagmin 2. (738 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1219 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
MYL6BMyosin light chain 6B. (235 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ESYT1Extended synaptotagmin 1. (1106 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
GnasUncharacterized protein. (244 aa)
ADMAdrenomedullin. (188 aa)
CALM3Calmodulin 3. (149 aa)
PLA2G5Phospholipase A(2). (161 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
LOC101967288Uncharacterized protein. (848 aa)
RAMP1Receptor activity modifying protein 1. (165 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1795 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSSTOP00000029069EF-hand domain-containing protein. (222 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
ENSSTOP00000030497SER_THR_PHOSPHATASE domain-containing protein. (298 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
ENSSTOP00000030720ETS domain-containing protein. (133 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
PLA2G4APhospholipase A2. (750 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
ENSSTOP00000032372Uncharacterized protein. (128 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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