STRINGSTRING
GNGT1 GNGT1 ADCY5 ADCY5 MYLK MYLK CCND1 CCND1 SNAPIN SNAPIN SERPINE1 SERPINE1 MAPK3 MAPK3 GNG3 GNG3 PIK3R4 PIK3R4 PIK3CG PIK3CG TFAM TFAM GNA13 GNA13 RRAS RRAS I3LZZ8_ICTTR I3LZZ8_ICTTR GABARAPL1 GABARAPL1 PRKACA PRKACA Map2k2 Map2k2 ADCY4 ADCY4 MYL4 MYL4 AKT2 AKT2 MYL3 MYL3 UCP1 UCP1 ADCY10 ADCY10 NOTCH3 NOTCH3 SMAD2 SMAD2 MYLK3 MYLK3 SLC8A3 SLC8A3 ADCY6 ADCY6 GNG13 GNG13 GNG12 GNG12 CAMK4 CAMK4 ADCY2 ADCY2 UCP3 UCP3 ADCY9 ADCY9 GNB4 GNB4 PIK3R6 PIK3R6 PIK3R5 PIK3R5 PTRHD1 PTRHD1 ADCY3 ADCY3 PRKAG3 PRKAG3 I3M8I4_ICTTR I3M8I4_ICTTR GNGT2 GNGT2 MYLK2 MYLK2 RRAD RRAD CALML3 CALML3 FBXO21 FBXO21 NRF1 NRF1 PRKAB1 PRKAB1 GNG5 GNG5 GNAI3 GNAI3 ADCY1 ADCY1 MAP2K1 MAP2K1 KRAS KRAS GNG11 GNG11 PLAT PLAT SLC9A1 SLC9A1 EFCAB3 EFCAB3 SMAD3 SMAD3 PRKAA2 PRKAA2 GNB1 GNB1 AKT3 AKT3 UCP2 UCP2 GEM GEM HDAC4 HDAC4 Lipe Lipe GNAI1 GNAI1 SPHK2 SPHK2 MRAS MRAS PRKCE PRKCE TGFBR1 TGFBR1 PIK3C3 PIK3C3 GNB5 GNB5 PRKAG1 PRKAG1 RYR2 RYR2 MAPK1 MAPK1 CALML4 CALML4 ACTA2 ACTA2 GNB3 GNB3 GNG4 GNG4 PDE3B PDE3B PLCB1 PLCB1 GNAI2 GNAI2 CALM1 CALM1 GNB2 GNB2 GNG2 GNG2 NRAS NRAS GABARAP GABARAP I3MUP6_ICTTR I3MUP6_ICTTR CCN2 CCN2 CALML6 CALML6 EGR1 EGR1 RYR1 RYR1 I3MWX8_ICTTR I3MWX8_ICTTR RPS6KB2 RPS6KB2 SMAD4 SMAD4 AGTR1 AGTR1 GNG8 GNG8 NOS2 NOS2 SPP1 SPP1 PLIN1 PLIN1 I3N418_ICTTR I3N418_ICTTR MYLK4 MYLK4 I3N654_ICTTR I3N654_ICTTR PLIN3 PLIN3 RRAS2 RRAS2 MFSD6L MFSD6L Rps6kb1 Rps6kb1 BECN2 BECN2 ERAS ERAS REM1 REM1 SPHK1 SPHK1 GABARAPL2 GABARAPL2 APLNR APLNR TMEM145 TMEM145 GNG7 GNG7 RPS6 RPS6 CALM2 CALM2 Gng10 Gng10 NOS1 NOS1 PRKAA1 PRKAA1 SLC8A2 SLC8A2 ITPR2 ITPR2 PLCB4 PLCB4 ENSSTOP00000024467 ENSSTOP00000024467 MEF2A MEF2A MEF2B MEF2B Becn1 Becn1 LOC101955741 LOC101955741 ITPR3 ITPR3 HDAC5 HDAC5 PPARGC1A PPARGC1A JAG1 JAG1 CALM3 CALM3 PRKAG2 PRKAG2 ITPR1 ITPR1 PLCB2 PLCB2 LOC101975023 LOC101975023 SLC8A1 SLC8A1 APLN APLN ENSSTOP00000028121 ENSSTOP00000028121 AKT1 AKT1 HRAS HRAS ADCY7 ADCY7 PRKACB PRKACB ENSSTOP00000029069 ENSSTOP00000029069 ENSSTOP00000029937 ENSSTOP00000029937 MYL2 MYL2 ADCY8 ADCY8 PLCB3 PLCB3 Gng14 Gng14 NOS3 NOS3 MEF2C MEF2C RYR3 RYR3 PRKAB2 PRKAB2 Csde1 Csde1 MEF2D MEF2D MTOR MTOR ENSSTOP00000032237 ENSSTOP00000032237 CDH1 CDH1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
MYLKMyosin light chain kinase. (1897 aa)
CCND1Cyclin D1. (250 aa)
SNAPINSNAP associated protein. (125 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1305 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1071 aa)
TFAMTranscription factor A, mitochondrial. (246 aa)
GNA13G protein subunit alpha 13. (306 aa)
RRASRAS related. (218 aa)
I3LZZ8_ICTTR40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (223 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
MYL4Myosin light chain 4. (193 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
MYL3Myosin light chain 3. (197 aa)
UCP1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
ADCY10Adenylate cyclase 10. (1610 aa)
NOTCH3Notch receptor 3. (2277 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MYLK3Myosin light chain kinase 3. (813 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (929 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
UCP3Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (308 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNB4G protein subunit beta 4. (340 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (748 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
I3M8I4_ICTTRUncharacterized protein. (917 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
MYLK2Myosin light chain kinase 2. (596 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
FBXO21F-box protein 21. (477 aa)
NRF1Nuclear respiratory factor 1. (501 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (560 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
EFCAB3EF-hand calcium binding domain 3. (432 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
GNB1G protein subunit beta 1. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1086 aa)
LipeHormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SPHK2Sphingosine kinase 2. (655 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (783 aa)
GNB5G protein subunit beta 5. (386 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
RYR2Ryanodine receptor 2. (4888 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
CALML4Calmodulin like 4. (153 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
GNB3G protein subunit beta 3. (340 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
PDE3BPhosphodiesterase. (1046 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
GNB2G protein subunit beta 2. (371 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GABARAPGABA type A receptor-associated protein. (117 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CCN2Cellular communication network factor 2. (348 aa)
CALML6Calmodulin like 6. (172 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
RYR1Ryanodine receptor 1. (4864 aa)
I3MWX8_ICTTR40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (253 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
SPP1Secreted phosphoprotein 1. (309 aa)
PLIN1Perilipin; Belongs to the perilipin family. (517 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
MYLK4Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (378 aa)
I3N654_ICTTR40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
PLIN3Perilipin; Belongs to the perilipin family. (465 aa)
RRAS2RAS related 2. (173 aa)
MFSD6LMajor facilitator superfamily domain containing 6 like. (597 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BECN2Beclin 2. (412 aa)
ERASES cell expressed Ras. (227 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (309 aa)
SPHK1Sphingosine kinase 1. (385 aa)
GABARAPL2GABA type A receptor associated protein like 2. (123 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
TMEM145Transmembrane protein 145. (563 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (219 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (779 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ENSSTOP0000002446740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (233 aa)
MEF2AMyocyte enhancer factor 2A. (496 aa)
MEF2BMyocyte enhancer factor 2B. (395 aa)
Becn1Beclin 1. (448 aa)
LOC101955741Guanylate cyclase domain-containing protein. (412 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1113 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CALM3Calmodulin 3. (149 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
APLNApelin. (75 aa)
ENSSTOP0000002812140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (236 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ENSSTOP00000029069EF-hand domain-containing protein. (222 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
MYL2Myosin light chain 2. (166 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
RYR3Ryanodine receptor 3. (4870 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
Csde1Uncharacterized protein. (555 aa)
MEF2DMyocyte enhancer factor 2D. (524 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
CDH1Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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