STRINGSTRING
IFNGR2 IFNGR2 NCF2 NCF2 MAPK3 MAPK3 TGFB2 TGFB2 PIK3CB PIK3CB MAPK10 MAPK10 Pik3r2 Pik3r2 NFKB2 NFKB2 IL1A IL1A IL1B IL1B TAB1 TAB1 Itgb3 Itgb3 AKT2 AKT2 FOS FOS GAB2 GAB2 FOSL1 FOSL1 TYK2 TYK2 ACP5 ACP5 CAMK4 CAMK4 Fcgr3a Fcgr3a BTK BTK NOX1 NOX1 PLCG2 PLCG2 SYK SYK IKBKB IKBKB MITF MITF NCF1 NCF1 RAC1 RAC1 TRAF6 TRAF6 FYN FYN NFKBIA NFKBIA LOC101972741 LOC101972741 PTK6 PTK6 SRMS SRMS NFATC1 NFATC1 STAT1 STAT1 FHL2 FHL2 MAP2K1 MAP2K1 TNFRSF11B TNFRSF11B LOC101962660 LOC101962660 TGFB1 TGFB1 TNFRSF1A TNFRSF1A TNFSF11 TNFSF11 CYLD CYLD TREM2 TREM2 AKT3 AKT3 SOCS3 SOCS3 I3MH84_ICTTR I3MH84_ICTTR NFKB1 NFKB1 Spib Spib PPP3CA PPP3CA CALCR CALCR IGSF1 IGSF1 TRAF2 TRAF2 MAPK8 MAPK8 GRB2 GRB2 BLNK BLNK PPARG PPARG TNF TNF PIK3CA PIK3CA TGFBR1 TGFBR1 CTSK CTSK MAPK1 MAPK1 IFNG IFNG IFNAR1 IFNAR1 MAPK12 MAPK12 MAPK11 MAPK11 STAT2 STAT2 CHUK CHUK CREB1 CREB1 LCP2 LCP2 Ppp3r1 Ppp3r1 LOC101965906 LOC101965906 PPP3CC PPP3CC TAB2 TAB2 IL1R1 IL1R1 RELCH RELCH Ncf4 Ncf4 TYROBP TYROBP CSF1R CSF1R RELA RELA IFNGR1 IFNGR1 I3MZ70_ICTTR I3MZ70_ICTTR TNFRSF11A TNFRSF11A IRF9 IRF9 JAK1 JAK1 Fcgr2b Fcgr2b CSF1 CSF1 LOC101968765 LOC101968765 SOCS1 SOCS1 SPI1 SPI1 FOSL2 FOSL2 JUN JUN OSCAR OSCAR LOC101966442 LOC101966442 FOSB FOSB MAPK14 MAPK14 LOC101970625 LOC101970625 MAPK13 MAPK13 NOXA1 NOXA1 CYBA CYBA LOC101968118 LOC101968118 TGFBR2 TGFBR2 JUNB JUNB PIK3R1 PIK3R1 RELB RELB IKBKG IKBKG TEC TEC AKT1 AKT1 NFATC2 NFATC2 Pik3r3 Pik3r3 Pik3cd Pik3cd MAP2K7 MAP2K7 MAPK9 MAPK9 MAP3K14 MAP3K14 Ifnar2 Ifnar2 MAP3K7 MAP3K7 SQSTM1 SQSTM1 PPP3CB PPP3CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGR2Interferon gamma receptor 2. (306 aa)
NCF2Neutrophil cytosolic factor 2. (525 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (792 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
TYK2Tyrosine-protein kinase. (1194 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (327 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
Fcgr3aUncharacterized protein. (253 aa)
BTKTyrosine-protein kinase. (659 aa)
NOX1NADPH oxidase 1. (561 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
SYKTyrosine-protein kinase. (626 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MITFMelanocyte inducing transcription factor. (482 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
RAC1Rac family small GTPase 1. (211 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
FYNTyrosine-protein kinase. (537 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
LOC101972741Uncharacterized protein. (363 aa)
PTK6Tyrosine-protein kinase. (450 aa)
SRMSTyrosine-protein kinase. (534 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (321 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (262 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SOCS3Suppressor of cytokine signaling 3. (227 aa)
I3MH84_ICTTRUncharacterized protein. (334 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
SpibETS domain-containing protein. (262 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (497 aa)
IGSF1Immunoglobulin superfamily member 1. (1317 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
BLNKB cell linker. (456 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (490 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
Ppp3r1Uncharacterized protein. (169 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
PPP3CCSerine/threonine-protein phosphatase. (487 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
IL1R1Interleukin 1 receptor type 1. (506 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1217 aa)
Ncf4Neutrophil cytosolic factor 4. (294 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (113 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (975 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
I3MZ70_ICTTRUncharacterized protein. (305 aa)
TNFRSF11ATNF receptor superfamily member 11a. (625 aa)
IRF9Interferon regulatory factor 9. (357 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
Fcgr2bUncharacterized protein. (341 aa)
CSF1Colony stimulating factor 1. (497 aa)
LOC101968765Uncharacterized protein. (187 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
SPI1Spi-1 proto-oncogene. (270 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
OSCAROsteoclast associated Ig-like receptor. (277 aa)
LOC101966442Uncharacterized protein. (370 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC101970625Uncharacterized protein. (328 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
NOXA1NADPH oxidase activator 1. (492 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RELBRELB proto-oncogene, NF-kB subunit. (567 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
TECTyrosine-protein kinase. (630 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (934 aa)
Ifnar2Uncharacterized protein. (516 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SQSTM1Sequestosome 1. (440 aa)
PPP3CBSerine/threonine-protein phosphatase. (523 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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