STRINGSTRING
Irak4 Irak4 MAP3K7 MAP3K7 Ifnar2 Ifnar2 MAPK9 MAPK9 MAP2K7 MAP2K7 TLR5 TLR5 Pik3cd Pik3cd Pik3r3 Pik3r3 ENSSTOP00000028887 ENSSTOP00000028887 Tmed7 Tmed7 AKT1 AKT1 IKBKG IKBKG LOC101969049 LOC101969049 PIK3R1 PIK3R1 IRAK1 IRAK1 BPI BPI LOC101968118 LOC101968118 FADD FADD TOLLIP TOLLIP TMED3 TMED3 Ikbke Ikbke CXCL10 CXCL10 LOC101961439 LOC101961439 MAPK13 MAPK13 MAPK14 MAPK14 CD40 CD40 LOC101967545 LOC101967545 TRAF3 TRAF3 MAPK3 MAPK3 PIK3CB PIK3CB RIPK1 RIPK1 MAPK10 MAPK10 Pik3r2 Pik3r2 IL1B IL1B TAB1 TAB1 Map2k2 Map2k2 Cd86 Cd86 AKT2 AKT2 FOS FOS CXCL8 CXCL8 I3M4W8_ICTTR I3M4W8_ICTTR IRF5 IRF5 IL12B IL12B IRF7 IRF7 IKBKB IKBKB TLR8 TLR8 MAP3K8 MAP3K8 RAC1 RAC1 TRAF6 TRAF6 NFKBIA NFKBIA TBK1 TBK1 STAT1 STAT1 MAP2K1 MAP2K1 CXCL11 CXCL11 MAP2K3 MAP2K3 LOC101962660 LOC101962660 TIRAP TIRAP AKT3 AKT3 CASP8 CASP8 NFKB1 NFKB1 LBP LBP MAPK8 MAPK8 TNF TNF PIK3CA PIK3CA LOC101968597 LOC101968597 LOC101968303 LOC101968303 MYD88 MYD88 CXCL9 CXCL9 CTSK CTSK IL12A IL12A MAPK1 MAPK1 IFNAR1 IFNAR1 MAPK12 MAPK12 MAPK11 MAPK11 BPIFC BPIFC CCL5 CCL5 CHUK CHUK LOC101965906 LOC101965906 TAB2 TAB2 I3MVL6_ICTTR I3MVL6_ICTTR CD14 CD14 SPP1 SPP1 RELA RELA TLR4 TLR4 I3N090_ICTTR I3N090_ICTTR TLR6 TLR6 MAP2K4 MAP2K4 LOC101960206 LOC101960206 IRF3 IRF3 TLR7 TLR7 LOC101968765 LOC101968765 TICAM2 TICAM2 TLR1 TLR1 CASP10 CASP10 JUN JUN TLR2 TLR2 TLR3 TLR3 IRF6 IRF6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
Ifnar2Uncharacterized protein. (516 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (899 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Pik3r3Uncharacterized protein. (461 aa)
ENSSTOP00000028887Uncharacterized protein. (184 aa)
Tmed7GOLD domain-containing protein. (225 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
LOC101969049Uncharacterized protein. (174 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
BPIBactericidal permeability increasing protein. (490 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TOLLIPToll interacting protein. (274 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CD40CD40 molecule. (284 aa)
LOC101967545C-C motif chemokine. (93 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
Cd86Ig-like domain-containing protein. (289 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
IRF5Interferon regulatory factor 5. (500 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
IRF7Interferon regulatory factor 7. (472 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
RAC1Rac family small GTPase 1. (211 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TBK1TANK binding kinase 1. (729 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
CXCL11C-X-C motif chemokine ligand 11. (100 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
LBPLipopolysaccharide binding protein. (481 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101968597C-C motif chemokine. (92 aa)
LOC101968303C-C motif chemokine. (93 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
CXCL9C-X-C motif chemokine. (125 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (490 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
BPIFCBPI fold containing family C. (507 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
SPP1Secreted phosphoprotein 1. (309 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
LOC101960206Uncharacterized protein. (207 aa)
IRF3Interferon regulatory factor 3. (420 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1055 aa)
LOC101968765Uncharacterized protein. (187 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
IRF6Interferon regulatory factor 6. (467 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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