STRINGSTRING
LOC101968765 LOC101968765 IRF3 IRF3 LOC101960206 LOC101960206 MAP2K4 MAP2K4 TLR6 TLR6 I3N090_ICTTR I3N090_ICTTR TLR4 TLR4 RELA RELA SPP1 SPP1 CD14 CD14 I3MVL6_ICTTR I3MVL6_ICTTR TAB2 TAB2 LOC101965906 LOC101965906 CHUK CHUK CCL5 CCL5 BPIFC BPIFC MAPK11 MAPK11 MAPK12 MAPK12 IFNAR1 IFNAR1 MAPK1 MAPK1 IL12A IL12A CTSK CTSK Irak4 Irak4 CXCL9 CXCL9 MYD88 MYD88 LOC101968303 LOC101968303 LOC101968597 LOC101968597 PIK3CA PIK3CA TNF TNF MAPK8 MAPK8 LBP LBP NFKB1 NFKB1 CASP8 CASP8 AKT3 AKT3 TIRAP TIRAP LOC101962660 LOC101962660 MAP2K3 MAP2K3 CXCL11 CXCL11 MAP2K1 MAP2K1 STAT1 STAT1 TBK1 TBK1 NFKBIA NFKBIA TRAF6 TRAF6 RAC1 RAC1 MAP3K8 MAP3K8 TLR8 TLR8 IKBKB IKBKB IRF7 IRF7 IL12B IL12B IRF5 IRF5 I3M4W8_ICTTR I3M4W8_ICTTR CXCL8 CXCL8 FOS FOS AKT2 AKT2 Cd86 Cd86 Map2k2 Map2k2 TAB1 TAB1 IL1B IL1B Pik3r2 Pik3r2 MAPK10 MAPK10 RIPK1 RIPK1 PIK3CB PIK3CB MAPK3 MAPK3 TRAF3 TRAF3 LOC101967545 LOC101967545 MAP3K7 MAP3K7 Ifnar2 Ifnar2 MAPK9 MAPK9 MAP2K7 MAP2K7 TLR5 TLR5 Pik3cd Pik3cd Pik3r3 Pik3r3 ENSSTOP00000028887 ENSSTOP00000028887 Tmed7 Tmed7 AKT1 AKT1 IKBKG IKBKG LOC101969049 LOC101969049 PIK3R1 PIK3R1 IRAK1 IRAK1 BPI BPI LOC101968118 LOC101968118 FADD FADD TOLLIP TOLLIP TMED3 TMED3 Ikbke Ikbke CXCL10 CXCL10 LOC101961439 LOC101961439 MAPK13 MAPK13 MAPK14 MAPK14 CD40 CD40 IRF6 IRF6 TLR3 TLR3 TLR2 TLR2 JUN JUN CASP10 CASP10 TLR1 TLR1 TICAM2 TICAM2 TLR7 TLR7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101968765Uncharacterized protein. (187 aa)
IRF3Interferon regulatory factor 3. (420 aa)
LOC101960206Uncharacterized protein. (207 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
TLR6Toll like receptor 6; Belongs to the Toll-like receptor family. (796 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
SPP1Secreted phosphoprotein 1. (309 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
BPIFCBPI fold containing family C. (507 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (490 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
CXCL9C-X-C motif chemokine. (125 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
LOC101968303C-C motif chemokine. (93 aa)
LOC101968597C-C motif chemokine. (92 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LBPLipopolysaccharide binding protein. (481 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
CXCL11C-X-C motif chemokine ligand 11. (100 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
TBK1TANK binding kinase 1. (729 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
RAC1Rac family small GTPase 1. (211 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1039 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IRF7Interferon regulatory factor 7. (472 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
IRF5Interferon regulatory factor 5. (500 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
Cd86Ig-like domain-containing protein. (289 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
Pik3r2Uncharacterized protein. (724 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
LOC101967545C-C motif chemokine. (93 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
Ifnar2Uncharacterized protein. (516 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (899 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Pik3r3Uncharacterized protein. (461 aa)
ENSSTOP00000028887Uncharacterized protein. (184 aa)
Tmed7GOLD domain-containing protein. (225 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
LOC101969049Uncharacterized protein. (174 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
BPIBactericidal permeability increasing protein. (490 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TOLLIPToll interacting protein. (274 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CD40CD40 molecule. (284 aa)
IRF6Interferon regulatory factor 6. (467 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
TLR1Toll like receptor 1; Belongs to the Toll-like receptor family. (795 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1055 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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