66 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NLRX1	NLR family member X1. (975 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (665 aa)
	MAPK10	Mitogen-activated protein kinase. (492 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IFIH1	Interferon induced with helicase C domain 1. (974 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	IRF7	Interferon regulatory factor 7. (472 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	DHX58	DExH-box helicase 58. (678 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1437 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	TANK	TRAF family member associated NFKB activator. (439 aa)
	DDX3X	DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (692 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	FGFR1OP2	FGFR1 oncogene partner 2. (185 aa)
	TRIM25	Tripartite motif containing 25. (644 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (520 aa)
	TRADD	TNFRSF1A associated via death domain. (302 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (985 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	COIL	Coilin. (529 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	TRIM47	Tripartite motif containing 47. (544 aa)
	TRIM65	Tripartite motif containing 65. (443 aa)
	OTUD5	OTU deubiquitinase 5. (569 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
	MAPK12	Mitogen-activated protein kinase. (325 aa)
	MAPK11	Mitogen-activated protein kinase. (325 aa)
	MAVS	Mitochondrial antiviral signaling protein. (509 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	RNF135	Ring finger protein 135. (421 aa)
	LOC101975998	Uncharacterized protein. (187 aa)
	LOC101971846	Uncharacterized protein. (187 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	LOC101955511	Uncharacterized protein. (626 aa)
	STING1	Transmembrane protein 173. (379 aa)
	IRF3	Interferon regulatory factor 3. (420 aa)
	NFKBIB	NFKB inhibitor beta. (359 aa)
	TBKBP1	TBK1 binding protein 1. (497 aa)
	AZI2	5-azacytidine induced 2. (393 aa)
	IFNE	Interferon epsilon. (184 aa)
	LOC101968765	Uncharacterized protein. (187 aa)
	Ifnk	Uncharacterized protein. (241 aa)
	LOC101975152	Uncharacterized protein. (187 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (480 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAPK13	Mitogen-activated protein kinase. (326 aa)
	RNF125	Ring finger protein 125. (232 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	Ikbke	Protein kinase domain-containing protein. (130 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	TKFC	Triokinase and FMN cyclase. (578 aa)
	LOC101969049	Uncharacterized protein. (174 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
	ENSSTOP00000028887	Uncharacterized protein. (184 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	ENSSTOP00000010542	ENSSTOP00000014775	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CASP10	ENSSTOP00000010542	ENSSTOP00000021797	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 10; Belongs to the peptidase C14A family.	0.412
ATG12	CASP8	ENSSTOP00000010542	ENSSTOP00000010179	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Caspase 8; Belongs to the peptidase C14A family.	0.412
ATG12	DDX58	ENSSTOP00000010542	ENSSTOP00000006269	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExD/H-box helicase 58.	0.945
ATG12	DHX58	ENSSTOP00000010542	ENSSTOP00000005836	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	DExH-box helicase 58.	0.830
ATG12	FADD	ENSSTOP00000010542	ENSSTOP00000024623	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.690
ATG12	IFIH1	ENSSTOP00000010542	ENSSTOP00000004468	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon induced with helicase C domain 1.	0.914
ATG12	MAVS	ENSSTOP00000010542	ENSSTOP00000013856	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral signaling protein.	0.955
ATG12	NLRX1	ENSSTOP00000010542	ENSSTOP00000030193	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1.	0.726
ATG5	ATG12	ENSSTOP00000014775	ENSSTOP00000010542	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	CASP10	ENSSTOP00000014775	ENSSTOP00000021797	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 10; Belongs to the peptidase C14A family.	0.639
ATG5	CASP8	ENSSTOP00000014775	ENSSTOP00000010179	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase 8; Belongs to the peptidase C14A family.	0.639
ATG5	DDX58	ENSSTOP00000014775	ENSSTOP00000006269	Autophagy protein 5; Involved in autophagic vesicle formation.	DExD/H-box helicase 58.	0.945
ATG5	DHX58	ENSSTOP00000014775	ENSSTOP00000005836	Autophagy protein 5; Involved in autophagic vesicle formation.	DExH-box helicase 58.	0.829
ATG5	FADD	ENSSTOP00000014775	ENSSTOP00000024623	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.750
ATG5	IFIH1	ENSSTOP00000014775	ENSSTOP00000004468	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon induced with helicase C domain 1.	0.912
ATG5	IKBKG	ENSSTOP00000014775	ENSSTOP00000026959	Autophagy protein 5; Involved in autophagic vesicle formation.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.405
ATG5	MAVS	ENSSTOP00000014775	ENSSTOP00000013856	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral signaling protein.	0.955
ATG5	NLRX1	ENSSTOP00000014775	ENSSTOP00000030193	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1.	0.764
ATG5	RIPK1	ENSSTOP00000014775	ENSSTOP00000001385	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor interacting serine/threonine kinase 1.	0.569