(55 nodes) Cytosolic DNA-sensing pathway network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLR2E	RNA polymerase II subunit E. (210 aa)
	IRF7	Interferon regulatory factor 7. (472 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	POLR2K	Uncharacterized protein. (58 aa)
	DDX58	DExD/H-box helicase 58. (925 aa)
	NFKBIA	NFKB inhibitor alpha. (314 aa)
	AIM2	Absent in melanoma 2. (349 aa)
	POLR2H	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	TBK1	TANK binding kinase 1. (729 aa)
	Polr3g	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (224 aa)
	POLR1C	RNA polymerase I and III subunit C. (346 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (985 aa)
	POLR3A	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1390 aa)
	LOC101968597	C-C motif chemokine. (92 aa)
	PYCARD	PYD and CARD domain containing. (194 aa)
	POLR3F	DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family. (316 aa)
	POLR1D	RNA polymerase I and III subunit D. (133 aa)
	Polr3gl	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (218 aa)
	ADAR	Adenosine deaminase RNA specific. (1165 aa)
	POLR3C	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
	MAVS	Mitochondrial antiviral signaling protein. (509 aa)
	CCL5	C-C motif chemokine ligand 5. (91 aa)
	POLR3H	RNA polymerase III subunit H. (204 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
	POLR3D	RNA polymerase III subunit D. (398 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (962 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	POLR3K	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	Polr2l	Uncharacterized protein. (83 aa)
	Cgas	Mab-21 domain-containing protein. (305 aa)
	ENSSTOP00000030987	Uncharacterized protein. (49 aa)
	POLR3E	RNA polymerase III subunit E. (711 aa)
	ENSSTOP00000028887	Uncharacterized protein. (184 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
	LOC101969049	Uncharacterized protein. (174 aa)
	IL33	Interleukin 33. (264 aa)
	POLR3B	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1133 aa)
	Ikbke	Protein kinase domain-containing protein. (130 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	I3NFC8_ICTTR	DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. (224 aa)
	NFKBIB	NFKB inhibitor beta. (359 aa)
	IRF3	Interferon regulatory factor 3. (420 aa)
	LOC101960206	Uncharacterized protein. (207 aa)
	STING1	Transmembrane protein 173. (379 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	POLR2F	RNA polymerase II subunit F. (127 aa)
	LOC101968765	Uncharacterized protein. (187 aa)
	TREX1	Three prime repair exonuclease 1. (304 aa)
	TREX2	Three prime repair exonuclease 2. (236 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (665 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAR	DDX58	ENSSTOP00000012687	ENSSTOP00000006269	Adenosine deaminase RNA specific.	DExD/H-box helicase 58.	0.405
ADAR	IRF7	ENSSTOP00000012687	ENSSTOP00000005114	Adenosine deaminase RNA specific.	Interferon regulatory factor 7.	0.517
ADAR	MAVS	ENSSTOP00000012687	ENSSTOP00000013856	Adenosine deaminase RNA specific.	Mitochondrial antiviral signaling protein.	0.605
AIM2	Cgas	ENSSTOP00000007285	ENSSTOP00000032196	Absent in melanoma 2.	Mab-21 domain-containing protein.	0.567
AIM2	DDX58	ENSSTOP00000007285	ENSSTOP00000006269	Absent in melanoma 2.	DExD/H-box helicase 58.	0.589
AIM2	IL18	ENSSTOP00000007285	ENSSTOP00000015111	Absent in melanoma 2.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.589
AIM2	IL1B	ENSSTOP00000007285	ENSSTOP00000002047	Absent in melanoma 2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.520
AIM2	PYCARD	ENSSTOP00000007285	ENSSTOP00000012013	Absent in melanoma 2.	PYD and CARD domain containing.	0.992
AIM2	STING1	ENSSTOP00000007285	ENSSTOP00000017977	Absent in melanoma 2.	Transmembrane protein 173.	0.774
CCL5	CXCL10	ENSSTOP00000014170	ENSSTOP00000023723	C-C motif chemokine ligand 5.	C-X-C motif chemokine.	0.990
CCL5	DDX58	ENSSTOP00000014170	ENSSTOP00000006269	C-C motif chemokine ligand 5.	DExD/H-box helicase 58.	0.408
CCL5	IL18	ENSSTOP00000014170	ENSSTOP00000015111	C-C motif chemokine ligand 5.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.432
CCL5	IL1B	ENSSTOP00000014170	ENSSTOP00000002047	C-C motif chemokine ligand 5.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.630
CCL5	IRF3	ENSSTOP00000014170	ENSSTOP00000018572	C-C motif chemokine ligand 5.	Interferon regulatory factor 3.	0.432
CCL5	IRF7	ENSSTOP00000014170	ENSSTOP00000005114	C-C motif chemokine ligand 5.	Interferon regulatory factor 7.	0.456
CCL5	LOC101968597	ENSSTOP00000014170	ENSSTOP00000011929	C-C motif chemokine ligand 5.	C-C motif chemokine.	0.908
CCL5	LOC101968765	ENSSTOP00000014170	ENSSTOP00000020234	C-C motif chemokine ligand 5.	Uncharacterized protein.	0.414
CCL5	MAVS	ENSSTOP00000014170	ENSSTOP00000013856	C-C motif chemokine ligand 5.	Mitochondrial antiviral signaling protein.	0.450
CCL5	NFKB1	ENSSTOP00000014170	ENSSTOP00000010277	C-C motif chemokine ligand 5.	Nuclear factor kappa B subunit 1.	0.896
CCL5	NFKBIA	ENSSTOP00000014170	ENSSTOP00000006784	C-C motif chemokine ligand 5.	NFKB inhibitor alpha.	0.656