STRINGSTRING
KSR1 KSR1 CLEC4E CLEC4E LOC101959358 LOC101959358 LOC101960206 LOC101960206 LOC101969495 LOC101969495 MALT1 MALT1 EGR3 EGR3 I3N090_ICTTR I3N090_ICTTR RELA RELA I3MW17_ICTTR I3MW17_ICTTR CALML6 CALML6 I3MVL6_ICTTR I3MVL6_ICTTR I3MUQ5_ICTTR I3MUQ5_ICTTR NRAS NRAS NFATC3 NFATC3 PPP3CC PPP3CC LOC101965906 LOC101965906 Ppp3r1 Ppp3r1 CLEC1B CLEC1B CHUK CHUK CALM1 CALM1 IL2 IL2 STAT2 STAT2 IL23A IL23A ARHGEF12 ARHGEF12 CALML4 CALML4 MAPK11 MAPK11 MAPK12 MAPK12 CCL17 CCL17 MAPK1 MAPK1 Mdm2 Mdm2 IL12A IL12A CARD9 CARD9 PYCARD PYCARD PIK3CA PIK3CA TNF TNF PAK1 PAK1 MAPK8 MAPK8 MRAS MRAS CLEC4D CLEC4D CBLB CBLB PPP3CA PPP3CA PPP3CB PPP3CB ENSSTOP00000032295 ENSSTOP00000032295 ENSSTOP00000032237 ENSSTOP00000032237 Plk5 Plk5 Csde1 Csde1 ENSSTOP00000031001 ENSSTOP00000031001 MAP3K14 MAP3K14 MAPK9 MAPK9 ENSSTOP00000029937 ENSSTOP00000029937 Pik3cd Pik3cd LOC101969790 LOC101969790 Pik3r3 Pik3r3 CLEC4G CLEC4G MAPK3 MAPK3 PIK3CB PIK3CB MAPK10 MAPK10 RRAS RRAS Pik3r2 Pik3r2 NFKB2 NFKB2 TMEM52B TMEM52B IL1B IL1B NFATC4 NFATC4 AKT2 AKT2 EGR2 EGR2 BCL3 BCL3 Rhoa Rhoa PRKCD PRKCD I3M4W8_ICTTR I3M4W8_ICTTR IL12B IL12B CLEC1A CLEC1A PLCG2 PLCG2 SYK SYK IKBKB IKBKB MAPKAPK2 MAPKAPK2 PLK3 PLK3 IL10 IL10 FCER1G FCER1G NFKBIA NFKBIA RRAD RRAD CALML3 CALML3 NFATC1 NFATC1 STAT1 STAT1 KRAS KRAS Ptgs2 Ptgs2 LOC101962660 LOC101962660 IRF1 IRF1 CYLD CYLD NLRP3 NLRP3 CCL22 CCL22 EFCAB3 EFCAB3 AKT3 AKT3 IL17D IL17D GEM GEM Clec4a Clec4a CASP8 CASP8 NFKB1 NFKB1 NFATC2 NFATC2 ENSSTOP00000029069 ENSSTOP00000029069 CLEC9A CLEC9A LOC101969219 LOC101969219 HRAS HRAS AKT1 AKT1 LOC101975023 LOC101975023 Clec7a Clec7a ITPR1 ITPR1 CALM3 CALM3 IKBKG IKBKG RELB RELB PIK3R1 PIK3R1 ITPR3 ITPR3 LOC101968118 LOC101968118 ENSSTOP00000024463 ENSSTOP00000024463 ITPR2 ITPR2 Ikbke Ikbke CEACAM16 CEACAM16 MAPK13 MAPK13 CALM2 CALM2 MAPK14 MAPK14 I3NEH4_ICTTR I3NEH4_ICTTR JUN JUN CASP10 CASP10 REM1 REM1 ERAS ERAS BCL10 BCL10 PTPN11 PTPN11 RRAS2 RRAS2 Rhoc Rhoc IRF9 IRF9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KSR1Kinase suppressor of ras 1. (876 aa)
CLEC4EC-type lectin domain family 4 member E. (214 aa)
LOC101959358Uncharacterized protein. (193 aa)
LOC101960206Uncharacterized protein. (207 aa)
LOC101969495C-type lectin domain-containing protein. (240 aa)
MALT1MALT1 paracaspase. (747 aa)
EGR3Early growth response 3. (387 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
I3MW17_ICTTRC-type lectin domain-containing protein. (242 aa)
CALML6Calmodulin like 6. (172 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
I3MUQ5_ICTTRRING-type domain-containing protein. (239 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
PPP3CCSerine/threonine-protein phosphatase. (487 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
Ppp3r1Uncharacterized protein. (169 aa)
CLEC1BC-type lectin domain family 1 member B. (230 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
STAT2Signal transducer and activator of transcription. (805 aa)
IL23AInterleukin 23 subunit alpha. (185 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1518 aa)
CALML4Calmodulin like 4. (153 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
CCL17C-C motif chemokine ligand 17. (102 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
Mdm2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (489 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
PYCARDPYD and CARD domain containing. (194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MRASMuscle RAS oncogene homolog. (208 aa)
CLEC4DC-type lectin domain family 4 member D. (218 aa)
CBLBCbl proto-oncogene B. (985 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
PPP3CBSerine/threonine-protein phosphatase. (523 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
Plk5Uncharacterized protein. (608 aa)
Csde1Uncharacterized protein. (555 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (934 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
LOC101969790C-type lectin domain-containing protein. (209 aa)
Pik3r3Uncharacterized protein. (461 aa)
CLEC4GC-type lectin domain family 4 member G. (295 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
RRASRAS related. (218 aa)
Pik3r2Uncharacterized protein. (724 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
TMEM52BTransmembrane protein 52B. (192 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
NFATC4Nuclear factor of activated T cells 4. (890 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
EGR2Early growth response 2. (423 aa)
BCL3BCL3 transcription coactivator. (440 aa)
RhoaRas homolog family member A. (193 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
CLEC1AC-type lectin domain family 1 member A. (273 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
SYKTyrosine-protein kinase. (626 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (358 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
IL10Interleukin 10. (178 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
IRF1Interferon regulatory factor. (326 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
CCL22C-C motif chemokine. (93 aa)
EFCAB3EF-hand calcium binding domain 3. (432 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
IL17DInterleukin 17D. (143 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
Clec4aC-type lectin domain-containing protein. (241 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
ENSSTOP00000029069EF-hand domain-containing protein. (222 aa)
CLEC9AC-type lectin domain containing 9A. (241 aa)
LOC101969219C-type lectin domain-containing protein. (264 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
Clec7aUncharacterized protein. (157 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
CALM3Calmodulin 3. (149 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
RELBRELB proto-oncogene, NF-kB subunit. (567 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
ENSSTOP00000024463RING-type domain-containing protein. (209 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
IkbkeProtein kinase domain-containing protein. (130 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (452 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
I3NEH4_ICTTRC-type lectin domain-containing protein. (207 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (309 aa)
ERASES cell expressed Ras. (227 aa)
BCL10BCL10 immune signaling adaptor. (153 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
RRAS2RAS related 2. (173 aa)
RhocUncharacterized protein. (193 aa)
IRF9Interferon regulatory factor 9. (357 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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