STRINGSTRING
DOCK1 DOCK1 CRK CRK LOC101968118 LOC101968118 PLPP1 PLPP1 PRKCG PRKCG LAT LAT PIK3R1 PIK3R1 PTPRC PTPRC ARPC3 ARPC3 ENSSTOP00000027636 ENSSTOP00000027636 ARPC4 ARPC4 ASAP1 ASAP1 ENSSTOP00000028111 ENSSTOP00000028111 AKT1 AKT1 Pik3r3 Pik3r3 LYN LYN Pik3cd Pik3cd Cfl1 Cfl1 ENSSTOP00000029646 ENSSTOP00000029646 ENSSTOP00000029727 ENSSTOP00000029727 PIP5K1C PIP5K1C PLA2G4A PLA2G4A LOC101966144 LOC101966144 PIP5K1A PIP5K1A Pla2g4b Pla2g4b Cdc42 Cdc42 MAPK3 MAPK3 PLA2G4C PLA2G4C PIK3CB PIK3CB Arpc1a Arpc1a Cfl2 Cfl2 ARPC1B ARPC1B Pik3r2 Pik3r2 AKT2 AKT2 PRKCA PRKCA WASF2 WASF2 GAB2 GAB2 ASAP2 ASAP2 PRKCD PRKCD Fcgr3a Fcgr3a MYO10 MYO10 GSN GSN PLCG2 PLCG2 SYK SYK Wasf1 Wasf1 NCF1 NCF1 RAC1 RAC1 ARPC5L ARPC5L CRKL CRKL MAP2K1 MAP2K1 ASAP3 ASAP3 LOC101962660 LOC101962660 PLD1 PLD1 AKT3 AKT3 VAV1 VAV1 INPPL1 INPPL1 INPP5D INPP5D SCIN SCIN PLCG1 PLCG1 MARCKSL1 MARCKSL1 SPHK2 SPHK2 AMPH AMPH PRKCB PRKCB Golga2 Golga2 PRKCE PRKCE PAK1 PAK1 LIMK1 LIMK1 PIK3CA PIK3CA PLA2G4E PLA2G4E PLA2G4D PLA2G4D PLA2G4F PLA2G4F MAPK1 MAPK1 PLD2 PLD2 ARPC2 ARPC2 LOC101965906 LOC101965906 I3MSG9_ICTTR I3MSG9_ICTTR RPS6KB2 RPS6KB2 WASF3 WASF3 RAC2 RAC2 PLPP2 PLPP2 DNM2 DNM2 I3N4S4_ICTTR I3N4S4_ICTTR LOC101973767 LOC101973767 Fcgr2b Fcgr2b I3N6Q6_ICTTR I3N6Q6_ICTTR WAS WAS LIMK2 LIMK2 Rps6kb1 Rps6kb1 CCDC125 CCDC125 SPHK1 SPHK1 Plpp3 Plpp3 VAV2 VAV2 JMJD7 JMJD7 LOC101966442 LOC101966442 PIP5K1B PIP5K1B ARF6 ARF6 ENSSTOP00000023976 ENSSTOP00000023976 ENSSTOP00000031635 ENSSTOP00000031635 PLA2G6 PLA2G6 BIN1 BIN1 ARPC5 ARPC5 VAV3 VAV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1849 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PLPP1Phospholipid phosphatase 1. (285 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LATLinker for activation of T cells. (234 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1180 aa)
ARPC3Actin related protein 2/3 complex subunit 3. (102 aa)
ENSSTOP00000027636Ig-like domain-containing protein. (165 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (176 aa)
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1. (1147 aa)
ENSSTOP00000028111Ig-like domain-containing protein. (135 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Pik3r3Uncharacterized protein. (461 aa)
LYNTyrosine-protein kinase. (512 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
ENSSTOP00000029646WH1 domain-containing protein. (363 aa)
ENSSTOP00000029727ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (152 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PLA2G4APhospholipase A2. (750 aa)
LOC101966144Uncharacterized protein. (147 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (537 aa)
Pla2g4bPhospholipase A2. (774 aa)
Cdc42Uncharacterized protein. (191 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
Arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
Cfl2ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (167 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
Pik3r2Uncharacterized protein. (724 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
WASF2WASP family member 2. (497 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2. (958 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
Fcgr3aUncharacterized protein. (253 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2048 aa)
GSNGelsolin. (748 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
SYKTyrosine-protein kinase. (626 aa)
Wasf1WH2 domain-containing protein. (559 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
RAC1Rac family small GTPase 1. (211 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
ASAP3ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (903 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
PLD1Phospholipase. (1037 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1213 aa)
SCINScinderin. (715 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
MARCKSL1MARCKS like 1. (178 aa)
SPHK2Sphingosine kinase 2. (655 aa)
AMPHAmphiphysin. (690 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
Golga2Uncharacterized protein. (1020 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
LIMK1LIM domain kinase 1. (628 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLA2G4EPhospholipase A2. (876 aa)
PLA2G4DPhospholipase A2. (827 aa)
PLA2G4FPhospholipase A2. (840 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
PLD2Phospholipase. (933 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
I3MSG9_ICTTRIg-like domain-containing protein. (186 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
WASF3WASP family member 3. (502 aa)
RAC2Rac family small GTPase 2. (192 aa)
PLPP2Phospholipid phosphatase 2. (287 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (870 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
LOC101973767WH1 domain-containing protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
Fcgr2bUncharacterized protein. (341 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
WASWASP actin nucleation promoting factor. (503 aa)
LIMK2LIM domain kinase 2. (638 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CCDC125Coiled-coil domain containing 125. (512 aa)
SPHK1Sphingosine kinase 1. (385 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
VAV2Vav guanine nucleotide exchange factor 2. (745 aa)
JMJD7Jumonji domain containing 7. (316 aa)
LOC101966442Uncharacterized protein. (370 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (452 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
ENSSTOP00000023976Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (151 aa)
ENSSTOP00000031635Uncharacterized protein. (493 aa)
PLA2G6Phospholipase A2 group VI. (807 aa)
BIN1Bridging integrator 1. (609 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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