STRINGSTRING
TRAF3 TRAF3 PIK3CB PIK3CB RIPK1 RIPK1 MAPK10 MAPK10 Pik3r2 Pik3r2 IL1B IL1B VEGFC VEGFC TAB1 TAB1 RIPK3 RIPK3 AKT2 AKT2 FOS FOS CASP7 CASP7 Casp3 Casp3 IL18R1 IL18R1 BCL3 BCL3 I3M4W8_ICTTR I3M4W8_ICTTR CREB3 CREB3 BIRC3 BIRC3 Birc2 Birc2 IL15 IL15 IKBKB IKBKB LIF LIF MMP9 MMP9 VEGFD VEGFD MAP3K8 MAP3K8 BAG4 BAG4 NFKBIA NFKBIA TNFAIP3 TNFAIP3 Mmp10 Mmp10 MMP3 MMP3 SELE SELE MAP3K5 MAP3K5 MAP2K1 MAP2K1 MAP2K3 MAP2K3 Ptgs2 Ptgs2 LOC101962660 LOC101962660 CREB3L2 CREB3L2 IRF1 IRF1 TNFRSF1A TNFRSF1A RFWD3 RFWD3 AKT3 AKT3 SOCS3 SOCS3 CASP8 CASP8 TRADD TRADD NFKB1 NFKB1 DNM1L DNM1L TRAF2 TRAF2 MAPK8 MAPK8 CREB3L1 CREB3L1 LTA LTA TNF TNF PIK3CA PIK3CA LOC101954372 LOC101954372 CSF2 CSF2 ATF2 ATF2 CREB3L4 CREB3L4 MAPK1 MAPK1 ITCH ITCH MAPK12 MAPK12 MAPK11 MAPK11 CCL5 CCL5 I3MQN1_ICTTR I3MQN1_ICTTR CHUK CHUK CREB1 CREB1 CREB3L3 CREB3L3 TNFRSF1B TNFRSF1B LOC101965906 LOC101965906 TAB2 TAB2 LOC101958458 LOC101958458 I3MVL6_ICTTR I3MVL6_ICTTR NOD2 NOD2 CCDC88B CCDC88B RELA RELA I3N090_ICTTR I3N090_ICTTR LOC101964412 LOC101964412 MAP2K4 MAP2K4 LOC101960206 LOC101960206 Vcam1 Vcam1 DAB2IP DAB2IP CSF1 CSF1 LOC101968765 LOC101968765 LOC106144852 LOC106144852 MMP14 MMP14 CASP10 CASP10 TRAF1 TRAF1 JUN JUN LOC101969207 LOC101969207 CX3CL1 CX3CL1 MAPK14 MAPK14 MAPK13 MAPK13 CEACAM16 CEACAM16 ATF4 ATF4 CXCL10 CXCL10 RPS6KA4 RPS6KA4 FADD FADD LOC101968118 LOC101968118 CFLAR CFLAR JUNB JUNB MLKL MLKL PIK3R1 PIK3R1 ICAM1 ICAM1 TRAF5 TRAF5 JAG1 JAG1 CREB5 CREB5 IKBKG IKBKG AKT1 AKT1 CXCL6 CXCL6 LOC101973519 LOC101973519 Pik3r3 Pik3r3 ATF6B ATF6B RPS6KA5 RPS6KA5 TAB3 TAB3 Pik3cd Pik3cd ENSSTOP00000030003 ENSSTOP00000030003 CCL20 CCL20 MAP2K7 MAP2K7 MAPK9 MAPK9 MAP3K14 MAP3K14 ENSSTOP00000031310 ENSSTOP00000031310 ENSSTOP00000032295 ENSSTOP00000032295 MAP3K7 MAP3K7 EDN1 EDN1 MAPK3 MAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (665 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (491 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (303 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
IL18R1Interleukin 18 receptor 1. (539 aa)
BCL3BCL3 transcription coactivator. (440 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
Birc2Uncharacterized protein. (611 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (359 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
BAG4BCL2 associated athanogene 4. (324 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
TNFAIP3TNF alpha induced protein 3. (776 aa)
Mmp10ZnMc domain-containing protein. (410 aa)
MMP3ZnMc domain-containing protein. (479 aa)
SELESelectin E. (495 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1307 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
IRF1Interferon regulatory factor. (326 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
RFWD3Ring finger and WD repeat domain 3. (808 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SOCS3Suppressor of cytokine signaling 3. (227 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
TRADDTNFRSF1A associated via death domain. (302 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (205 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC101954372C-X-C motif chemokine. (102 aa)
CSF2Colony stimulating factor 2. (138 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
ITCHE3 ubiquitin-protein ligase. (855 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
I3MQN1_ICTTRUncharacterized protein. (140 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
TNFRSF1BTNF receptor superfamily member 1B. (436 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
LOC101958458IRG-type G domain-containing protein. (422 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1014 aa)
CCDC88BCoiled-coil domain containing 88B. (1234 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
LOC101964412C-X-C motif chemokine. (102 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
LOC101960206Uncharacterized protein. (207 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
DAB2IPDAB2 interacting protein. (1148 aa)
CSF1Colony stimulating factor 1. (497 aa)
LOC101968765Uncharacterized protein. (187 aa)
LOC106144852IRG-type G domain-containing protein. (413 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
TRAF1TNF receptor-associated factor. (415 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC101969207C-C motif chemokine. (136 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (397 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
CEACAM16Carcinoembryonic antigen related cell adhesion molecule 16. (452 aa)
ATF4Activating transcription factor 4. (352 aa)
CXCL10C-X-C motif chemokine. (98 aa)
RPS6KA4Ribosomal protein S6 kinase. (800 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
MLKLMixed lineage kinase domain like pseudokinase. (472 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CXCL6C-X-C motif chemokine. (129 aa)
LOC101973519IRG-type G domain-containing protein. (400 aa)
Pik3r3Uncharacterized protein. (461 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
RPS6KA5Ribosomal protein S6 kinase. (859 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ENSSTOP00000030003Uncharacterized protein. (546 aa)
CCL20C-C motif chemokine ligand 20. (97 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (934 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
EDN1Endothelin 1. (202 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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