STRINGSTRING
ENSSTOP00000031499 ENSSTOP00000031499 CLDN19 CLDN19 NCF2 NCF2 CLDN15 CLDN15 Cdc42 Cdc42 RAPGEF3 RAPGEF3 CTNNA1 CTNNA1 CLDN7 CLDN7 PIK3CB PIK3CB ITGB2 ITGB2 MYL9 MYL9 RAPGEF4 RAPGEF4 Pik3r2 Pik3r2 MYL7 MYL7 MYLPF MYLPF ITGAL ITGAL PRKCA PRKCA ITGAM ITGAM BCAR1 BCAR1 Rhoa Rhoa CLDN18 CLDN18 THY1 THY1 JAM3 JAM3 PLCG2 PLCG2 LOC101966943 LOC101966943 MYL12B MYL12B CXCL12 CXCL12 CDH5 CDH5 RASSF5 RASSF5 CXCR4 CXCR4 MMP9 MMP9 NCF1 NCF1 RAC1 RAC1 Actg1 Actg1 CLDN17 CLDN17 CLDN11 CLDN11 GABPA GABPA GNAI3 GNAI3 CLDN16 CLDN16 ITK ITK CLDN1 CLDN1 LOC101962660 LOC101962660 ACTN1 ACTN1 ITGA4 ITGA4 CLDN9 CLDN9 CLDN10 CLDN10 ACTL9 ACTL9 VAV1 VAV1 RAP1B RAP1B ARHGAP35 ARHGAP35 PLCG1 PLCG1 GNAI1 GNAI1 PRKCB PRKCB PIK3CA PIK3CA MSN MSN ITGB1 ITGB1 PXN PXN LOC101978211 LOC101978211 LOC101977927 LOC101977927 Actb Actb MAPK12 MAPK12 MAPK11 MAPK11 VAV3 VAV3 LPXN LPXN CTNNB1 CTNNB1 GNAI2 GNAI2 ESAM ESAM LOC101965906 LOC101965906 RAP1A RAP1A CLDN6 CLDN6 MYL5 MYL5 TXK TXK ACTL7A ACTL7A ACTRT2 ACTRT2 Ncf4 Ncf4 MMP2 MMP2 CLDN23 CLDN23 RAC2 RAC2 LOC101954496 LOC101954496 ROCK2 ROCK2 I3MZY4_ICTTR I3MZY4_ICTTR CLDN3 CLDN3 LOC101971713 LOC101971713 ACTL8 ACTL8 PECAM1 PECAM1 CD99L2 CD99L2 CLDN2 CLDN2 CLDN5 CLDN5 LOC101959358 LOC101959358 Vcam1 Vcam1 CLDN20 CLDN20 I3N3K3_ICTTR I3N3K3_ICTTR SIPA1 SIPA1 ACTRT1 ACTRT1 ACTL7B ACTL7B I3N4S4_ICTTR I3N4S4_ICTTR LOC101973767 LOC101973767 ROCK1 ROCK1 Rhoc Rhoc PTPN11 PTPN11 CLDN25 CLDN25 JAM2 JAM2 RHOH RHOH OCLN OCLN CLDN14 CLDN14 CD99 CD99 I3NCC6_ICTTR I3NCC6_ICTTR VAV2 VAV2 CLDN4 CLDN4 ARHGAP5 ARHGAP5 CYBB CYBB MYL10 MYL10 MAPK14 MAPK14 MAPK13 MAPK13 NOXA1 NOXA1 AFDN AFDN CYBA CYBA LOC101968118 LOC101968118 PRKCG PRKCG PIK3R1 PIK3R1 ENSSTOP00000026119 ENSSTOP00000026119 ICAM1 ICAM1 CTNND1 CTNND1 ENSSTOP00000027109 ENSSTOP00000027109 VCL VCL ACTN4 ACTN4 Pik3r3 Pik3r3 Pik3cd Pik3cd ENSSTOP00000029646 ENSSTOP00000029646 EZR EZR PTK2B PTK2B ENSSTOP00000030397 ENSSTOP00000030397 MYL2 MYL2 F11R F11R ENSSTOP00000030810 ENSSTOP00000030810 ENSSTOP00000031001 ENSSTOP00000031001 PTK2 PTK2 LOC101966144 LOC101966144 ENSSTOP00000031475 ENSSTOP00000031475
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSSTOP00000031499Uncharacterized protein. (157 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
NCF2Neutrophil cytosolic factor 2. (525 aa)
CLDN15Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (227 aa)
Cdc42Uncharacterized protein. (191 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (898 aa)
CTNNA1Catenin alpha 1. (906 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
ITGB2Integrin beta. (769 aa)
MYL9Myosin light chain 9. (172 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (985 aa)
Pik3r2Uncharacterized protein. (724 aa)
MYL7Myosin light chain 7. (176 aa)
MYLPFMyosin light chain, phosphorylatable, fast skeletal muscle. (169 aa)
ITGALIntegrin subunit alpha L; Belongs to the integrin alpha chain family. (1149 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1120 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (874 aa)
RhoaRas homolog family member A. (193 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
THY1Thy-1 cell surface antigen. (162 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
LOC101966943Uncharacterized protein. (172 aa)
MYL12BMyosin light chain 12B. (172 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (784 aa)
RASSF5Ras association domain family member 5. (313 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
RAC1Rac family small GTPase 1. (211 aa)
Actg1Uncharacterized protein. (375 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
CLDN11Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
GNAI3G protein subunit alpha i3. (354 aa)
CLDN16Claudin 16. (200 aa)
ITKTyrosine-protein kinase. (620 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
ACTN1Actinin alpha 1. (892 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
CLDN9Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (217 aa)
CLDN10Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (231 aa)
ACTL9Actin like 9; Belongs to the actin family. (415 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
RAP1BRAP1B, member of RAS oncogene family. (159 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
GNAI1G protein subunit alpha i1. (354 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MSNMoesin. (577 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (424 aa)
LOC101978211Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
LOC101977927Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
ActbActin beta. (375 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
CTNNB1Catenin beta 1. (781 aa)
GNAI2G protein subunit alpha i2. (355 aa)
ESAMEndothelial cell adhesion molecule. (393 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
CLDN6Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (221 aa)
MYL5Myosin light chain 5. (172 aa)
TXKTyrosine-protein kinase. (526 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (435 aa)
Ncf4Neutrophil cytosolic factor 4. (294 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
CLDN23Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (294 aa)
RAC2Rac family small GTPase 2. (192 aa)
LOC101954496Uncharacterized protein. (346 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
I3MZY4_ICTTRUncharacterized protein. (356 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
LOC101971713Uncharacterized protein; Belongs to the actin family. (1238 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (740 aa)
CD99L2CD99 molecule like 2. (251 aa)
CLDN2Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (230 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
LOC101959358Uncharacterized protein. (193 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
CLDN20Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
I3N3K3_ICTTRUncharacterized protein. (81 aa)
SIPA1Signal-induced proliferation-associated 1. (1032 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
ACTL7BActin like 7B; Belongs to the actin family. (418 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
LOC101973767WH1 domain-containing protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (381 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
RhocUncharacterized protein. (193 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
CLDN25Claudin 25. (229 aa)
JAM2Junctional adhesion molecule 2. (298 aa)
RHOHRas homolog family member H. (190 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (524 aa)
CLDN14Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (239 aa)
CD99CD99 molecule (Xg blood group). (166 aa)
I3NCC6_ICTTRUncharacterized protein; Belongs to the actin family. (340 aa)
VAV2Vav guanine nucleotide exchange factor 2. (745 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
ARHGAP5Rho GTPase activating protein 5. (1503 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
MYL10Myosin light chain 10. (147 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
NOXA1NADPH oxidase activator 1. (492 aa)
AFDNAfadin, adherens junction formation factor. (1801 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSSTOP00000026119Uncharacterized protein. (143 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
CTNND1Catenin delta 1. (967 aa)
ENSSTOP00000027109Uncharacterized protein. (193 aa)
VCLVinculin. (1134 aa)
ACTN4Actinin alpha 4. (933 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ENSSTOP00000029646WH1 domain-containing protein. (363 aa)
EZREzrin. (604 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ENSSTOP00000030397Uncharacterized protein; Belongs to the actin family. (148 aa)
MYL2Myosin light chain 2. (166 aa)
F11RF11 receptor. (298 aa)
ENSSTOP00000030810Uncharacterized protein. (168 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
LOC101966144Uncharacterized protein. (147 aa)
ENSSTOP00000031475Uncharacterized protein; Belongs to the actin family. (173 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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