(52 nodes) Intestinal immune network for IgA production network (Ictidomys tridecemlineatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (808 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (934 aa)
	CCR10	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	LOC101970873	Ig-like domain-containing protein. (251 aa)
	ICOS	Inducible T cell costimulator. (216 aa)
	Tnfrsf13c	Uncharacterized protein. (104 aa)
	ENSSTOP00000028111	Ig-like domain-containing protein. (135 aa)
	ENSSTOP00000027636	Ig-like domain-containing protein. (165 aa)
	TNFSF13	TNF superfamily member 13; Belongs to the tumor necrosis factor family. (250 aa)
	Icoslg	Uncharacterized protein. (292 aa)
	CD40	CD40 molecule. (284 aa)
	LOC101959667	Ig-like domain-containing protein. (272 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (280 aa)
	CD300LB	CD300 molecule like family member b. (184 aa)
	TREML2	Triggering receptor expressed on myeloid cells like 2. (314 aa)
	Madcam1	Mucosal vascular addressin cell adhesion molecule 1. (349 aa)
	LOC101957991	Ig-like domain-containing protein. (249 aa)
	LOC101960206	Uncharacterized protein. (207 aa)
	CD28	CD28 molecule. (221 aa)
	I3N090_ICTTR	Uncharacterized protein. (207 aa)
	Dnmt3l	PHD-type domain-containing protein. (358 aa)
	CCR9	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	I3MVL6_ICTTR	Uncharacterized protein. (192 aa)
	Tnfrsf13b	Uncharacterized protein. (120 aa)
	I3MSG9_ICTTR	Ig-like domain-containing protein. (186 aa)
	LOC101970595	Ig-like domain-containing protein. (264 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	LTBR	Lymphotoxin beta receptor. (435 aa)
	AICDA	Activation induced cytidine deaminase. (198 aa)
	HLA-DOA	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (220 aa)
	TNFRSF17	TNF receptor superfamily member 17. (182 aa)
	HLA-DRA	Major histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
	LOC101968188	Ig-like domain-containing protein. (266 aa)
	LOC101968486	Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
	HLA-DQB1	Major histocompatibility complex, class II, DQ beta 1. (269 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	HLA-DMA	Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (292 aa)
	PIGR	Polymeric immunoglobulin receptor. (760 aa)
	IL10	Interleukin 10. (178 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	Cd86	Ig-like domain-containing protein. (289 aa)
	HLA-DOB	Major histocompatibility complex, class II, DO beta. (282 aa)
	HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (254 aa)
	HLA-DPB1	Major histocompatibility complex, class II, DP beta 1. (288 aa)
	I3M4W8_ICTTR	Uncharacterized protein. (207 aa)
	CCL28	C-C motif chemokine. (121 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (134 aa)
	Il15ra	Sushi domain-containing protein. (309 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (259 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	CD40	ENSSTOP00000009840	ENSSTOP00000022884	Activation induced cytidine deaminase.	CD40 molecule.	0.471
AICDA	CD40LG	ENSSTOP00000009840	ENSSTOP00000005508	Activation induced cytidine deaminase.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.558
AICDA	CXCR4	ENSSTOP00000009840	ENSSTOP00000005647	Activation induced cytidine deaminase.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.425
AICDA	TNFSF13B	ENSSTOP00000009840	ENSSTOP00000021468	Activation induced cytidine deaminase.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.408
CCL28	CCR10	ENSSTOP00000005105	ENSSTOP00000030815	C-C motif chemokine.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.942
CCL28	CCR9	ENSSTOP00000005105	ENSSTOP00000016247	C-C motif chemokine.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.881
CCL28	CXCL12	ENSSTOP00000005105	ENSSTOP00000005317	C-C motif chemokine.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.968
CCL28	CXCR4	ENSSTOP00000005105	ENSSTOP00000005647	C-C motif chemokine.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.839
CCR10	CCL28	ENSSTOP00000030815	ENSSTOP00000005105	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.942
CCR10	CCR9	ENSSTOP00000030815	ENSSTOP00000016247	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	0.789
CCR10	CXCL12	ENSSTOP00000030815	ENSSTOP00000005317	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.918
CCR10	CXCR4	ENSSTOP00000030815	ENSSTOP00000005647	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.640
CCR10	Madcam1	ENSSTOP00000030815	ENSSTOP00000020536	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	Mucosal vascular addressin cell adhesion molecule 1.	0.408
CCR9	CCL28	ENSSTOP00000016247	ENSSTOP00000005105	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.881
CCR9	CCR10	ENSSTOP00000016247	ENSSTOP00000030815	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine receptor 10; Belongs to the G-protein coupled receptor 1 family.	0.789
CCR9	CD40	ENSSTOP00000016247	ENSSTOP00000022884	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	CD40 molecule.	0.434
CCR9	CXCL12	ENSSTOP00000016247	ENSSTOP00000005317	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.918
CCR9	CXCR4	ENSSTOP00000016247	ENSSTOP00000005647	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.643
CCR9	Cd86	ENSSTOP00000016247	ENSSTOP00000002363	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	Ig-like domain-containing protein.	0.407
CCR9	Madcam1	ENSSTOP00000016247	ENSSTOP00000020536	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family.	Mucosal vascular addressin cell adhesion molecule 1.	0.609