STRINGSTRING
PLCB1 PLCB1 GNG4 GNG4 GNB3 GNB3 CALML4 CALML4 CACNA1C CACNA1C MAPK1 MAPK1 RYR2 RYR2 KCNJ3 KCNJ3 GNB5 GNB5 PER3 PER3 ADCYAP1R1 ADCYAP1R1 GUCY1A2 GUCY1A2 PRKCB PRKCB GNAI1 GNAI1 ADCYAP1 ADCYAP1 I3MGY8_ICTTR I3MGY8_ICTTR NOS1AP NOS1AP GNB1 GNB1 GNG11 GNG11 GNGT1 GNGT1 GRIN2C GRIN2C GRIA3 GRIA3 CAMK2A CAMK2A MTNR1B MTNR1B GRIA1 GRIA1 ADCY1 ADCY1 GNAI3 GNAI3 GNG5 GNG5 PER2 PER2 FBXO21 FBXO21 CALML3 CALML3 Gnao1 Gnao1 GNGT2 GNGT2 LOC101964576 LOC101964576 ADCY3 ADCY3 PTRHD1 PTRHD1 PER1 PER1 GNB4 GNB4 ADCY9 ADCY9 ADCY2 ADCY2 GNG12 GNG12 GNG13 GNG13 ADCY6 ADCY6 ADCY10 ADCY10 PRKCA PRKCA FOS FOS ADCY4 ADCY4 PRKACA PRKACA GNG3 GNG3 GRIN2B GRIN2B CAMK2D CAMK2D MTNR1A MTNR1A CACNA1G CACNA1G C1orf226 C1orf226 GRIN2D GRIN2D RASD1 RASD1 PRKACB PRKACB ADCY7 ADCY7 LOC101967288 LOC101967288 PLCB2 PLCB2 RPS6KA5 RPS6KA5 PRKG1 PRKG1 CACNA1D CACNA1D GUCY1B1 GUCY1B1 ENSSTOP00000029937 ENSSTOP00000029937 KCNJ6 KCNJ6 ADCY8 ADCY8 PLCB3 PLCB3 Gng14 Gng14 RYR3 RYR3 ENSSTOP00000032237 ENSSTOP00000032237 MAPK3 MAPK3 CAMK2B CAMK2B GRIA4 GRIA4 ADCY5 ADCY5 ARSI ARSI KCNJ5 KCNJ5 I3N418_ICTTR I3N418_ICTTR CACNA1I CACNA1I GNG8 GNG8 RYR1 RYR1 ITPR1 ITPR1 KCNJ9 KCNJ9 CALM3 CALM3 Gnas Gnas GRIA2 GRIA2 PRKCG PRKCG GRIN1 GRIN1 GUCY1A1 GUCY1A1 ITPR3 ITPR3 LOC101955741 LOC101955741 PLCB4 PLCB4 CAMK2G CAMK2G GRIN2A GRIN2A NOS1 NOS1 Gng10 Gng10 CALM2 CALM2 LOC101967418 LOC101967418 GNG7 GNG7 CALML6 CALML6 Cacna1h Cacna1h I3MUP6_ICTTR I3MUP6_ICTTR GNG2 GNG2 GNB2 GNB2 CREB1 CREB1 CALM1 CALM1 GNAI2 GNAI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
GNB3G protein subunit beta 3. (340 aa)
CALML4Calmodulin like 4. (153 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
RYR2Ryanodine receptor 2. (4888 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
GNB5G protein subunit beta 5. (386 aa)
PER3Period circadian regulator 3. (1062 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (480 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (631 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
GNAI1G protein subunit alpha i1. (354 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
I3MGY8_ICTTRAGC-kinase C-terminal domain-containing protein. (107 aa)
NOS1APNitric oxide synthase 1 adaptor protein. (502 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GRIN2CGlutamate ionotropic receptor NMDA type subunit 2C; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1047 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (899 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (364 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (837 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
PER2Period circadian regulator 2. (1297 aa)
FBXO21F-box protein 21. (477 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
Gnao1G protein subunit alpha o1. (344 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
LOC101964576Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (734 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
PER1Period circadian regulator 1. (1294 aa)
GNB4G protein subunit beta 4. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG13G protein subunit gamma 13. (67 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
ADCY10Adenylate cyclase 10. (1610 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
C1orf226Chromosome 1 open reading frame 226. (287 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (1394 aa)
RASD1Ras related dexamethasone induced 1. (280 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
LOC101967288Uncharacterized protein. (848 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
RPS6KA5Ribosomal protein S6 kinase. (859 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (426 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
RYR3Ryanodine receptor 3. (4870 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
ARSIArylsulfatase family member I. (572 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (1804 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
RYR1Ryanodine receptor 1. (4864 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
CALM3Calmodulin 3. (149 aa)
GnasUncharacterized protein. (244 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (959 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
LOC101955741Guanylate cyclase domain-containing protein. (412 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
LOC101967418Uncharacterized protein. (2364 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CALML6Calmodulin like 6. (172 aa)
Cacna1hUncharacterized protein. (2259 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNB2G protein subunit beta 2. (371 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
GNAI2G protein subunit alpha i2. (355 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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