STRINGSTRING
MAPK3 MAPK3 CHRNB4 CHRNB4 KCNQ2 KCNQ2 Csde1 Csde1 Gng14 Gng14 PLCB3 PLCB3 ADCY8 ADCY8 KCNJ6 KCNJ6 CACNA1D CACNA1D Pik3cd Pik3cd KCNQ5 KCNQ5 Pik3r3 Pik3r3 PRKACB PRKACB ADCY7 ADCY7 HRAS HRAS AKT1 AKT1 CACNA1S CACNA1S CACNA1A CACNA1A LOC101975023 LOC101975023 CHRNB2 CHRNB2 PLCB2 PLCB2 ITPR1 ITPR1 CREB5 CREB5 PIK3R1 PIK3R1 PRKCG PRKCG ITPR3 ITPR3 LOC101968118 LOC101968118 PLCB4 PLCB4 CAMK2G CAMK2G ITPR2 ITPR2 ATF4 ATF4 CHRM2 CHRM2 CHRM4 CHRM4 Gng10 Gng10 GNG7 GNG7 I3NE76_ICTTR I3NE76_ICTTR CAMK2D CAMK2D ACHE ACHE Kcnj12 Kcnj12 CHRM3 CHRM3 GNA11 GNA11 ERAS ERAS SLC18A3 SLC18A3 KCNQ1 KCNQ1 I3N418_ICTTR I3N418_ICTTR ARSI ARSI KCNJ4 KCNJ4 CHRM5 CHRM5 CHAT CHAT GNG8 GNG8 CACNA1F CACNA1F BCL2 BCL2 I3MUP6_ICTTR I3MUP6_ICTTR GNAQ GNAQ NRAS NRAS GNG2 GNG2 GNB2 GNB2 LOC101965906 LOC101965906 CHRNA4 CHRNA4 CREB3L3 CREB3L3 CREB1 CREB1 GNAI2 GNAI2 PLCB1 PLCB1 KCNJ2 KCNJ2 GNG4 GNG4 GNB3 GNB3 CACNA1C CACNA1C MAPK1 MAPK1 CREB3L4 CREB3L4 KCNJ3 KCNJ3 GNB5 GNB5 PIK3CA PIK3CA CREB3L1 CREB3L1 PRKCB PRKCB GNAI1 GNAI1 KCNQ3 KCNQ3 AKT3 AKT3 GNB1 GNB1 CREB3L2 CREB3L2 LOC101962660 LOC101962660 GNG11 GNG11 GNGT1 GNGT1 KRAS KRAS MAP2K1 MAP2K1 CAMK2A CAMK2A ADCY1 ADCY1 GNAI3 GNAI3 GNG5 GNG5 SRMS SRMS PTK6 PTK6 Gnao1 Gnao1 CHRNA3 CHRNA3 GNGT2 GNGT2 FYN FYN JAK2 JAK2 ADCY3 ADCY3 SLC5A7 SLC5A7 PTRHD1 PTRHD1 PIK3R5 PIK3R5 PIK3R6 PIK3R6 CREB3 CREB3 GNB4 GNB4 ADCY9 ADCY9 ADCY2 ADCY2 CACNA1B CACNA1B CAMK4 CAMK4 CHRM1 CHRM1 GNG12 GNG12 GNG13 GNG13 ADCY6 ADCY6 PRKCA PRKCA FOS FOS AKT2 AKT2 ADCY4 ADCY4 PRKACA PRKACA CHRNA6 CHRNA6 Pik3r2 Pik3r2 KCNQ4 KCNQ4 PIK3CG PIK3CG PIK3CB PIK3CB GNG3 GNG3 CAMK2B CAMK2B KCNJ14 KCNJ14 ADCY5 ADCY5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase. (361 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (497 aa)
KCNQ2Potassium voltage-gated channel subfamily Q member 2; Belongs to the potassium channel family. (867 aa)
Csde1Uncharacterized protein. (555 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (426 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
KCNQ5Potassium voltage-gated channel subfamily Q member 5. (948 aa)
Pik3r3Uncharacterized protein. (461 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1795 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (599 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ATF4Activating transcription factor 4. (352 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
CHRM4Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (478 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
I3NE76_ICTTRUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (435 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (614 aa)
Kcnj12Uncharacterized protein. (537 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
GNA11G protein subunit alpha 11. (359 aa)
ERASES cell expressed Ras. (227 aa)
SLC18A3Solute carrier family 18 member A3. (531 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (592 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
ARSIArylsulfatase family member I. (572 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (440 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (397 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (646 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1981 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAQG protein subunit alpha q. (313 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNB2G protein subunit beta 2. (371 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (617 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
GNB5G protein subunit beta 5. (386 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
GNAI1G protein subunit alpha i1. (354 aa)
KCNQ3Potassium voltage-gated channel subfamily Q member 3; Belongs to the potassium channel family. (872 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GNB1G protein subunit beta 1. (340 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SRMSTyrosine-protein kinase. (534 aa)
PTK6Tyrosine-protein kinase. (450 aa)
Gnao1G protein subunit alpha o1. (344 aa)
CHRNA3Cholinergic receptor nicotinic alpha 3 subunit. (502 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
FYNTyrosine-protein kinase. (537 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (580 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (871 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (748 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
GNB4G protein subunit beta 4. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2316 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
GNG13G protein subunit gamma 13. (67 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
CHRNA6Cholinergic receptor nicotinic alpha 6 subunit. (494 aa)
Pik3r2Uncharacterized protein. (724 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (629 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1071 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (434 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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