STRINGSTRING
ADCY5 ADCY5 LOC101965174 LOC101965174 Pla2g4b Pla2g4b MAPK3 MAPK3 RAPGEF3 RAPGEF3 GNG3 GNG3 PLA2G4C PLA2G4C PTGS1 PTGS1 PRKACA PRKACA BRAF BRAF I3M0S0_ICTTR I3M0S0_ICTTR HTR3B HTR3B TPH2 TPH2 HTR2A HTR2A CYP2W1 CYP2W1 ALOX15B ALOX15B PRKCA PRKCA TPH1 TPH1 GABRB2 GABRB2 DDC DDC HTR1F HTR1F Casp3 Casp3 ARAF ARAF SLC6A4 SLC6A4 GNG13 GNG13 GNG12 GNG12 CACNA1B CACNA1B ALOXE3 ALOXE3 MAOA MAOA MAOB MAOB GNB4 GNB4 SLC18A2 SLC18A2 ALOX12 ALOX12 Htr1d Htr1d HTR4 HTR4 GNGT2 GNGT2 Gnao1 Gnao1 HTR2B HTR2B ENSSTOP00000032295 ENSSTOP00000032295 PELP1 PELP1 ENSSTOP00000031310 ENSSTOP00000031310 PLA2G4A PLA2G4A Csde1 Csde1 Gng14 Gng14 PLCB3 PLCB3 KCNJ6 KCNJ6 CACNA1D CACNA1D TRPC1 TRPC1 PRKACB PRKACB HRAS HRAS CACNA1S CACNA1S CACNA1A CACNA1A LOC101975023 LOC101975023 LOC101967288 LOC101967288 PLCB2 PLCB2 ITPR1 ITPR1 KCNJ9 KCNJ9 GABRB3 GABRB3 APP APP Gnas Gnas PRKCG PRKCG LOC101954639 LOC101954639 ITPR3 ITPR3 KCND2 KCND2 LOC101961588 LOC101961588 HTR7 HTR7 PLCB4 PLCB4 ITPR2 ITPR2 ENSSTOP00000024194 ENSSTOP00000024194 LOC101964311 LOC101964311 LOC101970793 LOC101970793 Gng10 Gng10 HTR1B HTR1B LOC101976375 LOC101976375 GNG7 GNG7 I3NDM7_ICTTR I3NDM7_ICTTR JMJD7 JMJD7 LOC101972028 LOC101972028 ALOX12B ALOX12B ERAS ERAS Kcnn2 Kcnn2 LOC101977482 LOC101977482 HTR6 HTR6 I3N708_ICTTR I3N708_ICTTR ALOX15 ALOX15 HTR2C HTR2C RAF1 RAF1 I3N418_ICTTR I3N418_ICTTR LOC101976849 LOC101976849 KCNJ5 KCNJ5 LOC101972885 LOC101972885 GNG8 GNG8 HTR1A HTR1A CACNA1F CACNA1F I3MUP6_ICTTR I3MUP6_ICTTR LOC101978322 LOC101978322 ALOX5 ALOX5 NRAS NRAS GNG2 GNG2 GNB2 GNB2 LOC101971054 LOC101971054 DUSP1 DUSP1 HTR1E HTR1E GNAI2 GNAI2 PLCB1 PLCB1 LOC101978105 LOC101978105 GNG4 GNG4 GNB3 GNB3 CACNA1C CACNA1C MAPK1 MAPK1 HTR5A HTR5A KCNJ3 KCNJ3 PLA2G4F PLA2G4F PLA2G4D PLA2G4D PLA2G4E PLA2G4E GNB5 GNB5 CYP4X1 CYP4X1 PRKCB PRKCB GNAI1 GNAI1 SLC18A1 SLC18A1 LOC101963157 LOC101963157 LOC101975536 LOC101975536 GNB1 GNB1 GNG11 GNG11 GNGT1 GNGT1 Ptgs2 Ptgs2 KRAS KRAS GABRB1 GABRB1 GNG5 GNG5 GNAI3 GNAI3 MAP2K1 MAP2K1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
LOC101965174Uncharacterized protein; Belongs to the cytochrome P450 family. (467 aa)
Pla2g4bPhospholipase A2. (774 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (898 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLA2G4CPhospholipase A2 group IVC. (571 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (578 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (754 aa)
I3M0S0_ICTTRNeur_chan_memb domain-containing protein. (222 aa)
HTR3B5-hydroxytryptamine receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (331 aa)
TPH2Tryptophan hydroxylase 2. (491 aa)
HTR2A5-hydroxytryptamine receptor 2A. (472 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (490 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (678 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
DDCDopa decarboxylase. (432 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2316 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
MAOAAmine oxidase. (527 aa)
MAOBAmine oxidase. (520 aa)
GNB4G protein subunit beta 4. (340 aa)
SLC18A2Solute carrier family 18 member A2. (518 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (664 aa)
Htr1dG_PROTEIN_RECEP_F1_2 domain-containing protein. (378 aa)
HTR45-hydroxytryptamine receptor 4; Belongs to the G-protein coupled receptor 1 family. (388 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Gnao1G protein subunit alpha o1. (344 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
PELP1Proline, glutamate and leucine rich protein 1. (1152 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
PLA2G4APhospholipase A2. (750 aa)
Csde1Uncharacterized protein. (555 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (426 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (748 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1795 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
LOC101967288Uncharacterized protein. (848 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (493 aa)
APPAmyloid beta precursor protein. (739 aa)
GnasUncharacterized protein. (244 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
LOC101954639Uncharacterized protein. (394 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (630 aa)
LOC101961588Uncharacterized protein; Belongs to the cytochrome P450 family. (437 aa)
HTR75-hydroxytryptamine receptor 7; Belongs to the G-protein coupled receptor 1 family. (465 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
ENSSTOP00000024194Uncharacterized protein. (421 aa)
LOC101964311Uncharacterized protein. (486 aa)
LOC101970793Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
HTR1B5-hydroxytryptamine receptor 1B. (391 aa)
LOC101976375Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
I3NDM7_ICTTRUncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
JMJD7Jumonji domain containing 7. (316 aa)
LOC101972028Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (701 aa)
ERASES cell expressed Ras. (227 aa)
Kcnn2CaMBD domain-containing protein. (258 aa)
LOC101977482Uncharacterized protein; Belongs to the cytochrome P450 family. (340 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (438 aa)
I3N708_ICTTRUncharacterized protein; Belongs to the cytochrome P450 family. (476 aa)
ALOX15Arachidonate 15-lipoxygenase. (663 aa)
HTR2C5-hydroxytryptamine receptor 2C. (462 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
LOC101976849Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
LOC101972885Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
HTR1A5-hydroxytryptamine receptor 1A. (423 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1981 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC101978322Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
ALOX5Arachidonate 5-lipoxygenase. (663 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
GNB2G protein subunit beta 2. (371 aa)
LOC101971054Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
DUSP1Dual specificity phosphatase 1. (272 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
GNAI2G protein subunit alpha i2. (355 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101978105Uncharacterized protein; Belongs to the cytochrome P450 family. (487 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
GNB3G protein subunit beta 3. (340 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
HTR5A5-hydroxytryptamine receptor 5A. (357 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
PLA2G4FPhospholipase A2. (840 aa)
PLA2G4DPhospholipase A2. (827 aa)
PLA2G4EPhospholipase A2. (876 aa)
GNB5G protein subunit beta 5. (386 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (509 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
GNAI1G protein subunit alpha i1. (354 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
LOC101963157Uncharacterized protein. (662 aa)
LOC101975536G_PROTEIN_RECEP_F1_2 domain-containing protein. (370 aa)
GNB1G protein subunit beta 1. (340 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GABRB1Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (474 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI3G protein subunit alpha i3. (354 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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