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ARNTL ARNTL DRD3 DRD3 PPP2R5E PPP2R5E PPP3CA PPP3CA GNAL GNAL SLC18A1 SLC18A1 Arr3 Arr3 LOC101965228 LOC101965228 AKT3 AKT3 PPP2CA PPP2CA GNB1 GNB1 CREB3L2 CREB3L2 GNG11 GNG11 GNGT1 GNGT1 PPP1CC PPP1CC PPP2R3C PPP2R3C GRIA3 GRIA3 CAMK2A CAMK2A ADCY5 ADCY5 GRIA4 GRIA4 CAMK2B CAMK2B PPP1R1B PPP1R1B GSK3A GSK3A GRIN2B GRIN2B GNG3 GNG3 PPP2R1A PPP2R1A MAPK10 MAPK10 PRKACA PRKACA AKT2 AKT2 FOS FOS PRKCA PRKCA DRD2 DRD2 DDC DDC GNG13 GNG13 GNG12 GNG12 CACNA1B CACNA1B MAOA MAOA MAOB MAOB GNB4 GNB4 CREB3 CREB3 SLC18A2 SLC18A2 CALY CALY GNGT2 GNGT2 Gnao1 Gnao1 CALML3 CALML3 GNG5 GNG5 GNAI3 GNAI3 GRIA1 GRIA1 GNAI2 GNAI2 DRD4 DRD4 GNG8 GNG8 PPP1CB PPP1CB PPP2R2A PPP2R2A PLCB1 PLCB1 GNG4 GNG4 GNB3 GNB3 CALML4 CALML4 MAPK11 MAPK11 MAPK12 MAPK12 CACNA1C CACNA1C PPP2R3A PPP2R3A CREB3L4 CREB3L4 KCNJ3 KCNJ3 ATF2 ATF2 GNB5 GNB5 PPP2R5A PPP2R5A CREB3L1 CREB3L1 MAPK8 MAPK8 PPP2R2D PPP2R2D PRKCB PRKCB SCN1A SCN1A KCNJ5 KCNJ5 ARSI ARSI COMT COMT I3N418_ICTTR I3N418_ICTTR SLC6A3 SLC6A3 PPP2R5D PPP2R5D DRD5 DRD5 PPP2R5B PPP2R5B TH TH I3NDK4_ICTTR I3NDK4_ICTTR CAMK2D CAMK2D GNG7 GNG7 MAPK14 MAPK14 CALM2 CALM2 Gng10 Gng10 GSK3B GSK3B GRIN2A GRIN2A MAPK13 MAPK13 ATF4 ATF4 ARRB2 ARRB2 ARRB1 ARRB1 ITPR2 ITPR2 CAMK2G CAMK2G PLCB4 PLCB4 KIF5B KIF5B ITPR3 ITPR3 PRKCG PRKCG GRIA2 GRIA2 PPP1CA PPP1CA PPP2R1B PPP2R1B Gnas Gnas CREB5 CREB5 CALM3 CALM3 KCNJ9 KCNJ9 KIF5A KIF5A ITPR1 ITPR1 PLCB2 PLCB2 LOC101967288 LOC101967288 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 CACNA1A CACNA1A KIF5C KIF5C PPP2R5C PPP2R5C AKT1 AKT1 PRKACB PRKACB ATF6B ATF6B PPP2R2C PPP2R2C CACNA1D CACNA1D ENSSTOP00000029937 ENSSTOP00000029937 KCNJ6 KCNJ6 PPP2R2B PPP2R2B ENSSTOP00000030497 ENSSTOP00000030497 MAPK9 MAPK9 PLCB3 PLCB3 Gng14 Gng14 ENSSTOP00000032237 ENSSTOP00000032237 ENSSTOP00000032383 ENSSTOP00000032383 PPP3CB PPP3CB CALM1 CALM1 CREB1 CREB1 CREB3L3 CREB3L3 PPP3CC PPP3CC GNB2 GNB2 GNG2 GNG2 DRD1 DRD1 I3MUP6_ICTTR I3MUP6_ICTTR CALML6 CALML6 GNAI1 GNAI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (445 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
GNALG protein subunit alpha L. (378 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
Arr3Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity). (393 aa)
LOC101965228Uncharacterized protein. (191 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
GNB1G protein subunit beta 1. (340 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
GRIA3Glutamate ionotropic receptor AMPA type subunit 3. (899 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
GRIA4Glutamate ionotropic receptor AMPA type subunit 4. (902 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (666 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (203 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (395 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
DDCDopa decarboxylase. (432 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2316 aa)
MAOAAmine oxidase. (527 aa)
MAOBAmine oxidase. (520 aa)
GNB4G protein subunit beta 4. (340 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
SLC18A2Solute carrier family 18 member A2. (518 aa)
CALYCalcyon neuron specific vesicular protein. (218 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Gnao1G protein subunit alpha o1. (344 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI3G protein subunit alpha i3. (354 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (837 aa)
GNAI2G protein subunit alpha i2. (355 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (374 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
GNB3G protein subunit beta 3. (340 aa)
CALML4Calmodulin like 4. (153 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
PPP2R3AProtein phosphatase 2 regulatory subunit B''alpha. (1149 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
GNB5G protein subunit beta 5. (386 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (439 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1998 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
ARSIArylsulfatase family member I. (572 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (265 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (587 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (603 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (480 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa)
THTyrosine hydroxylase. (497 aa)
I3NDK4_ICTTRUncharacterized protein. (258 aa)
CAMK2DCalcium/calmodulin dependent protein kinase II delta. (514 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1423 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
ATF4Activating transcription factor 4. (352 aa)
ARRB2Arrestin beta 2. (409 aa)
ARRB1Arrestin beta 1. (418 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (512 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
GRIA2Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
GnasUncharacterized protein. (244 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
CALM3Calmodulin 3. (149 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1039 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
LOC101967288Uncharacterized protein. (848 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (426 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
ENSSTOP00000030497SER_THR_PHOSPHATASE domain-containing protein. (298 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
ENSSTOP00000032383Uncharacterized protein. (131 aa)
PPP3CBSerine/threonine-protein phosphatase. (523 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
PPP3CCSerine/threonine-protein phosphatase. (487 aa)
GNB2G protein subunit beta 2. (371 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (445 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
CALML6Calmodulin like 6. (172 aa)
GNAI1G protein subunit alpha i1. (354 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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