138 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	SHC1	SHC adaptor protein 1. (583 aa)
	I3LWF9_ICTTR	SH2 domain-containing protein. (118 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (326 aa)
	MAPK3	Mitogen-activated protein kinase. (361 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	KRT24	Keratin 24; Belongs to the intermediate filament family. (360 aa)
	KRT25	Keratin 25; Belongs to the intermediate filament family. (450 aa)
	KRT27	Keratin 27; Belongs to the intermediate filament family. (453 aa)
	KRT10	Keratin 10; Belongs to the intermediate filament family. (563 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
	Map2k2	Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	GABBR1	Gamma-aminobutyric acid type B receptor subunit 1. (984 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
	SHC4	SHC adaptor protein 4. (630 aa)
	I3M249_ICTTR	Uncharacterized protein. (683 aa)
	HSPA8	Heat shock protein family A (Hsp70) member 8; Belongs to the heat shock protein 70 family. (646 aa)
	GABBR2	Gamma-aminobutyric acid type B receptor subunit 2. (822 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	CREB3	cAMP responsive element binding protein 3. (374 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (805 aa)
	SP1	Sp1 transcription factor. (788 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
	POMC	Proopiomelanocortin. (212 aa)
	MMP9	Matrix metallopeptidase 9. (667 aa)
	EGFR	Receptor protein-tyrosine kinase. (1192 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (593 aa)
	Gnao1	G protein subunit alpha o1. (344 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	HSP90AA1	Heat shock protein 90 alpha family class A member 1. (733 aa)
	LOC101962660	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (522 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	Hspa1a	Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa)
	CCDC170	Coiled-coil domain containing 170. (629 aa)
	LOC101976426	IF rod domain-containing protein; Belongs to the intermediate filament family. (347 aa)
	KRT39	Keratin 39; Belongs to the intermediate filament family. (454 aa)
	KRT35	Keratin 35; Belongs to the intermediate filament family. (402 aa)
	Krt33a	IF rod domain-containing protein; Belongs to the intermediate filament family. (404 aa)
	KRT12	Keratin 12; Belongs to the intermediate filament family. (459 aa)
	KRT23	Keratin 23; Belongs to the intermediate filament family. (422 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
	KRT32	Keratin 32; Belongs to the intermediate filament family. (453 aa)
	KRT36	Keratin 36; Belongs to the intermediate filament family. (386 aa)
	I3MMU3_ICTTR	IF rod domain-containing protein; Belongs to the intermediate filament family. (387 aa)
	KRT15	Keratin 15; Belongs to the intermediate filament family. (465 aa)
	KCNJ3	Potassium voltage-gated channel subfamily J member 3. (499 aa)
	KRT19	Keratin 19; Belongs to the intermediate filament family. (397 aa)
	KRT16	Keratin 16; Belongs to the intermediate filament family. (476 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (394 aa)
	MAPK1	Mitogen-activated protein kinase. (331 aa)
	EBAG9	Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
	CALML4	Calmodulin like 4. (153 aa)
	KRT18	Keratin 18; Belongs to the intermediate filament family. (431 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	CALM1	Calmodulin 1; Belongs to the calmodulin family. (148 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	Ctsd	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (411 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (442 aa)
	LOC101965906	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
	NRAS	NRAS proto-oncogene, GTPase. (189 aa)
	BCL2	BCL2 apoptosis regulator. (195 aa)
	CALML6	Calmodulin like 6. (172 aa)
	MMP2	Matrix metallopeptidase 2. (662 aa)
	IFITM10	Interferon induced transmembrane protein 10. (200 aa)
	Hspa1b	Heat shock protein family A (Hsp70) member 1B. (641 aa)
	KCNJ5	Potassium voltage-gated channel subfamily J member 5. (419 aa)
	HSPA1L	Heat shock protein family A (Hsp70) member 1 like; Belongs to the heat shock protein 70 family. (641 aa)
	LOC101958852	Uncharacterized protein. (579 aa)
	PGR	Progesterone receptor. (932 aa)
	FKBP5	Peptidylprolyl isomerase. (457 aa)
	ERAS	ES cell expressed Ras. (227 aa)
	NCOA2	Nuclear receptor coactivator. (1465 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	HSP90AB1	Heat shock protein 90 alpha family class B member 1. (724 aa)
	HSPA6	Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (643 aa)
	CALM2	Calmodulin 2; Belongs to the calmodulin family. (149 aa)
	LOC101975245	HATPase_c domain-containing protein. (733 aa)
	LOC101959317	IF rod domain-containing protein; Belongs to the intermediate filament family. (453 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	FKBP4	Peptidylprolyl isomerase. (459 aa)
	HBEGF	Heparin binding EGF like growth factor. (208 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	CEP152	Centrosomal protein 152. (1507 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	TGFA	Transforming growth factor alpha. (159 aa)
	LOC101968118	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
	LOC101976712	IF rod domain-containing protein; Belongs to the intermediate filament family. (302 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	Gnas	Uncharacterized protein. (244 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
	CALM3	Calmodulin 3. (149 aa)
	KCNJ9	Potassium voltage-gated channel subfamily J member 9. (393 aa)
	KRT28	Keratin 28; Belongs to the intermediate filament family. (287 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	LOC101967288	Uncharacterized protein. (848 aa)
	LOC101975023	CSD_1 domain-containing protein. (729 aa)
	LOC101976142	IF rod domain-containing protein; Belongs to the intermediate filament family. (313 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	Pik3r3	Uncharacterized protein. (461 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	ESR2	Estrogen receptor 2. (525 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
	ENSSTOP00000029937	Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
	KCNJ6	Potassium voltage-gated channel subfamily J member 6. (426 aa)
	NCOA3	Nuclear receptor coactivator. (1413 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
	KRT26	Keratin 26; Belongs to the intermediate filament family. (402 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
	Csde1	Uncharacterized protein. (555 aa)
	Shc2	Uncharacterized protein. (581 aa)
	NCOA1	Nuclear receptor coactivator. (1442 aa)
	ENSSTOP00000032237	Uncharacterized protein; Belongs to the calmodulin family. (148 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSSTOP00000007821	ENSSTOP00000004376	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.599
ADCY1	ADCY3	ENSSTOP00000007821	ENSSTOP00000005426	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.843
ADCY1	ADCY4	ENSSTOP00000007821	ENSSTOP00000002179	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.587
ADCY1	ADCY5	ENSSTOP00000007821	ENSSTOP00000000037	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.580
ADCY1	ADCY6	ENSSTOP00000007821	ENSSTOP00000003745	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.580
ADCY1	ADCY7	ENSSTOP00000007821	ENSSTOP00000028572	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.619
ADCY1	ADCY8	ENSSTOP00000007821	ENSSTOP00000030610	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.843
ADCY1	ADCY9	ENSSTOP00000007821	ENSSTOP00000004525	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.833
ADCY1	AKT1	ENSSTOP00000007821	ENSSTOP00000028457	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY1	AKT2	ENSSTOP00000007821	ENSSTOP00000002612	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY1	AKT3	ENSSTOP00000007821	ENSSTOP00000009513	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY1	CALM1	ENSSTOP00000007821	ENSSTOP00000014633	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 1; Belongs to the calmodulin family.	0.674
ADCY1	CALM2	ENSSTOP00000007821	ENSSTOP00000023145	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 2; Belongs to the calmodulin family.	0.674
ADCY1	CALM3	ENSSTOP00000007821	ENSSTOP00000027029	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin 3.	0.674
ADCY1	CALML3	ENSSTOP00000007821	ENSSTOP00000007300	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.883
ADCY1	CALML4	ENSSTOP00000007821	ENSSTOP00000013905	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 4.	0.867
ADCY1	CALML6	ENSSTOP00000007821	ENSSTOP00000016185	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.901
ADCY1	Csde1	ENSSTOP00000007821	ENSSTOP00000031051	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.439
ADCY1	ENSSTOP00000029937	ENSSTOP00000007821	ENSSTOP00000029937	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.674
ADCY1	ENSSTOP00000032237	ENSSTOP00000007821	ENSSTOP00000032237	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.674