63 items (Ictidomys tridecemlineatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADRB1	Adrenoceptor beta 1. (418 aa)
	PNPLA2	Patatin like phospholipase domain containing 2. (489 aa)
	PTGER3	Prostaglandin E receptor 3. (388 aa)
	LOC101968118	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (138 aa)
	NPY	Neuropeptide Y. (97 aa)
	IRS4	Insulin receptor substrate 4. (1228 aa)
	ADORA1	Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa)
	PLAAT3	Phospholipase A and acyltransferase 3. (189 aa)
	MGLL	Monoglyceride lipase. (311 aa)
	NPR1	Guanylate cyclase. (1037 aa)
	ENSSTOP00000032295	Uncharacterized protein. (488 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	PRKG1	cGMP-dependent protein kinase. (686 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	Adrb3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (404 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	LOC101967288	Uncharacterized protein. (848 aa)
	Gnas	Uncharacterized protein. (244 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	Pik3r3	Uncharacterized protein. (461 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	INSR	Tyrosine-protein kinase receptor. (1359 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	PTGS1	Prostaglandin-endoperoxide synthase 1. (578 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	ABHD5	Abhydrolase domain containing 5. (349 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
	Aqp7	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (223 aa)
	I3MA50_ICTTR	Uncharacterized protein. (220 aa)
	PMP2	Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	FABP9	Fatty acid binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (131 aa)
	Fabp4	Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). FABPs are important elements related to the hibernating state in mammals. (132 aa)
	FABP12	Fatty acid binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	GNAI3	G protein subunit alpha i3. (354 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	Ptgs2	EGF-like domain-containing protein. (605 aa)
	LOC101962660	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
	I3MF93_ICTTR	Uncharacterized protein. (186 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	I3MGY8_ICTTR	AGC-kinase C-terminal domain-containing protein. (107 aa)
	Lipe	Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. (763 aa)
	GNAI1	G protein subunit alpha i1. (354 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PDE3B	Phosphodiesterase. (1046 aa)
	GNAI2	G protein subunit alpha i2. (355 aa)
	LOC101965906	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
	ADRB2	Adrenoceptor beta 2. (416 aa)
	Ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	LOC101975126	Uncharacterized protein. (498 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	PLIN1	Perilipin; Belongs to the perilipin family. (517 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD5	Lipe	ENSSTOP00000001853	ENSSTOP00000010392	Abhydrolase domain containing 5.	Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.	0.560
ABHD5	MGLL	ENSSTOP00000001853	ENSSTOP00000019904	Abhydrolase domain containing 5.	Monoglyceride lipase.	0.682
ABHD5	PLIN1	ENSSTOP00000001853	ENSSTOP00000017898	Abhydrolase domain containing 5.	Perilipin; Belongs to the perilipin family.	0.946
ABHD5	PNPLA2	ENSSTOP00000001853	ENSSTOP00000025960	Abhydrolase domain containing 5.	Patatin like phospholipase domain containing 2.	0.955
ADCY1	ADCY2	ENSSTOP00000007821	ENSSTOP00000004376	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.599
ADCY1	ADCY3	ENSSTOP00000007821	ENSSTOP00000005426	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.843
ADCY1	ADCY4	ENSSTOP00000007821	ENSSTOP00000002179	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.587
ADCY1	ADCY5	ENSSTOP00000007821	ENSSTOP00000000037	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.580
ADCY1	ADCY6	ENSSTOP00000007821	ENSSTOP00000003745	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.580
ADCY1	ADCY7	ENSSTOP00000007821	ENSSTOP00000028572	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.619
ADCY1	ADCY8	ENSSTOP00000007821	ENSSTOP00000030610	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.843
ADCY1	ADCY9	ENSSTOP00000007821	ENSSTOP00000004525	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.833
ADCY1	AKT1	ENSSTOP00000007821	ENSSTOP00000028457	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY1	AKT2	ENSSTOP00000007821	ENSSTOP00000002612	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY1	AKT3	ENSSTOP00000007821	ENSSTOP00000009513	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.859
ADCY1	GNAI1	ENSSTOP00000007821	ENSSTOP00000010973	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i1.	0.890
ADCY1	GNAI2	ENSSTOP00000007821	ENSSTOP00000014501	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i2.	0.891
ADCY1	GNAI3	ENSSTOP00000007821	ENSSTOP00000007797	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha i3.	0.887
ADCY1	Gnas	ENSSTOP00000007821	ENSSTOP00000026819	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.851
ADCY1	I3MA50_ICTTR	ENSSTOP00000007821	ENSSTOP00000006837	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.630