STRINGSTRING
ARRB2 ARRB2 COL3A1 COL3A1 Shc2 Shc2 Csde1 Csde1 NOS3 NOS3 Gng14 Gng14 PLCB3 PLCB3 MAPK9 MAPK9 ADCY8 ADCY8 MAP2K7 MAP2K7 SOS1 SOS1 Pik3cd Pik3cd ATF6B ATF6B Pik3r3 Pik3r3 MFF MFF PRKACB PRKACB ADCY7 ADCY7 HRAS HRAS AKT1 AKT1 LOC101975023 LOC101975023 LOC101967288 LOC101967288 PLCB2 PLCB2 CREB5 CREB5 Gnas Gnas PIK3R1 PIK3R1 COL1A1 COL1A1 TGFBR2 TGFBR2 LOC101968118 LOC101968118 PLCB4 PLCB4 CEP152 CEP152 ADCY5 ADCY5 SHC1 SHC1 COL4A4 COL4A4 I3LWF9_ICTTR I3LWF9_ICTTR EDN1 EDN1 RXFP4 RXFP4 MAPK3 MAPK3 GNG3 GNG3 PIK3CB PIK3CB MAPK10 MAPK10 Pik3r2 Pik3r2 VEGFC VEGFC PRKACA PRKACA Map2k2 Map2k2 ADCY4 ADCY4 AKT2 AKT2 FOS FOS SHC4 SHC4 SMAD2 SMAD2 COL4A6 COL4A6 ADCY6 ADCY6 COL4A1 COL4A1 GNG13 GNG13 GNG12 GNG12 ADCY2 ADCY2 RXFP1 RXFP1 ADCY9 ADCY9 GNB4 GNB4 CREB3 CREB3 PTRHD1 PTRHD1 ADCY3 ADCY3 MMP9 MMP9 VEGFD VEGFD EGFR EGFR NFKBIA NFKBIA GNGT2 GNGT2 Gnao1 Gnao1 FBXO21 FBXO21 MMP1 MMP1 MMP13 MMP13 GNG5 GNG5 GNAI3 GNAI3 ADCY1 ADCY1 VEGFA VEGFA MAP2K1 MAP2K1 EDNRB EDNRB KRAS KRAS GNGT1 GNGT1 GNG11 GNG11 LOC101962660 LOC101962660 CREB3L2 CREB3L2 TGFB1 TGFB1 GNB1 GNB1 AKT3 AKT3 RXFP2 RXFP2 COL1A2 COL1A2 I3MH86_ICTTR I3MH86_ICTTR NFKB1 NFKB1 Arr3 Arr3 GNAI1 GNAI1 MAPK8 MAPK8 GRB2 GRB2 CREB3L1 CREB3L1 PIK3CA PIK3CA TGFBR1 TGFBR1 GNB5 GNB5 ATF2 ATF2 VEGFB VEGFB CREB3L4 CREB3L4 MAPK1 MAPK1 MAPK12 MAPK12 MAPK11 MAPK11 ACTA2 ACTA2 GNB3 GNB3 GNG4 GNG4 PLCB1 PLCB1 GNAI2 GNAI2 INSL5 INSL5 CREB1 CREB1 CREB3L3 CREB3L3 LOC101965906 LOC101965906 GNB2 GNB2 GNG2 GNG2 NRAS NRAS Rxfp3 Rxfp3 I3MUP6_ICTTR I3MUP6_ICTTR RLN3 RLN3 MMP2 MMP2 GNG8 GNG8 NOS2 NOS2 RELA RELA MAP2K4 MAP2K4 I3N418_ICTTR I3N418_ICTTR COL4A2 COL4A2 ERAS ERAS JUN JUN GNA15 GNA15 GNG7 GNG7 MAPK14 MAPK14 Gng10 Gng10 NOS1 NOS1 MAPK13 MAPK13 ATF4 ATF4 ARRB1 ARRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ARRB2Arrestin beta 2. (409 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
Shc2Uncharacterized protein. (581 aa)
Csde1Uncharacterized protein. (555 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
Gng14Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1334 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
ATF6BActivating transcription factor 6 beta. (708 aa)
Pik3r3Uncharacterized protein. (461 aa)
MFFMitochondrial fission factor. (316 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
LOC101967288Uncharacterized protein. (848 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
GnasUncharacterized protein. (244 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
COL1A1Collagen type I alpha 1 chain. (1268 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
CEP152Centrosomal protein 152. (1507 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
SHC1SHC adaptor protein 1. (583 aa)
COL4A4Collagen type IV alpha 4 chain. (1583 aa)
I3LWF9_ICTTRSH2 domain-containing protein. (118 aa)
EDN1Endothelin 1. (202 aa)
RXFP4Relaxin family peptide/INSL5 receptor 4. (374 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
SHC4SHC adaptor protein 4. (630 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL4A6Collagen type IV alpha 6 chain. (1686 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
COL4A1Collagen type IV alpha 1 chain. (1671 aa)
GNG13G protein subunit gamma 13. (67 aa)
GNG12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
RXFP1Relaxin family peptide receptor 1. (755 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNB4G protein subunit beta 4. (340 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
MMP9Matrix metallopeptidase 9. (667 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (359 aa)
EGFRReceptor protein-tyrosine kinase. (1192 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
Gnao1G protein subunit alpha o1. (344 aa)
FBXO21F-box protein 21. (477 aa)
MMP1Matrix metallopeptidase 1. (449 aa)
MMP13Matrix metallopeptidase 13. (417 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (443 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GNB1G protein subunit beta 1. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RXFP2Relaxin family peptide receptor 2. (737 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
I3MH86_ICTTRUncharacterized protein. (310 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
Arr3Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity). (393 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
GNB5G protein subunit beta 5. (386 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (184 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
GNB3G protein subunit beta 3. (340 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (77 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI2G protein subunit alpha i2. (355 aa)
INSL5Insulin like 5. (135 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
GNB2G protein subunit beta 2. (371 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
Rxfp3G_PROTEIN_RECEP_F1_2 domain-containing protein. (468 aa)
I3MUP6_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
RLN3Relaxin 3. (142 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
I3N418_ICTTRGuanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (59 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ERASES cell expressed Ras. (227 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
GNA15G protein subunit alpha 15. (325 aa)
GNG7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
Gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1329 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
ATF4Activating transcription factor 4. (352 aa)
ARRB1Arrestin beta 1. (418 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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