(74 nodes) Cortisol synthesis and secretion network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	KCNA1	Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (476 aa)
	KCNK3	Potassium two pore domain channel subfamily K member 3; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (364 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (461 aa)
	LOC101968373	Uncharacterized protein; Belongs to the cytochrome P450 family. (514 aa)
	PRKACA	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (334 aa)
	ADCY4	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (955 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	CREB3	cAMP responsive element binding protein 3. (374 aa)
	SP1	Sp1 transcription factor. (788 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1144 aa)
	POMC	Proopiomelanocortin. (212 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (350 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (282 aa)
	CYP11A1	Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (519 aa)
	LDLR	Low density lipoprotein receptor. (863 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
	CREB3L2	cAMP responsive element binding protein 3 like 2. (522 aa)
	KCNK2	Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (422 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (519 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (504 aa)
	CYP17A1	Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (508 aa)
	CREB3L4	cAMP responsive element binding protein 3 like 4. (394 aa)
	CYP21A2	Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (492 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
	PDE8A	Phosphodiesterase. (766 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	CREB3L3	cAMP responsive element binding protein 3 like 3. (442 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (598 aa)
	GNAQ	G protein subunit alpha q. (313 aa)
	Cacna1h	Uncharacterized protein. (2259 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1981 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (477 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	LOC101960216	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	KCNA10	Potassium voltage-gated channel subfamily A member 10; Belongs to the potassium channel family. (511 aa)
	Pde8b	Phosphodiesterase. (865 aa)
	LOC101959454	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	CACNA1I	Calcium voltage-gated channel subunit alpha1 I. (1804 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (430 aa)
	KCNA4	Potassium voltage-gated channel subfamily A member 4; Belongs to the potassium channel family. (654 aa)
	Mrap	Uncharacterized protein. (108 aa)
	GNA11	G protein subunit alpha 11. (359 aa)
	PBX4	PBX homeobox 4. (355 aa)
	KCNA2	Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
	KCNA3	Potassium voltage-gated channel subfamily A member 3; Belongs to the potassium channel family. (495 aa)
	CACNA1G	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (482 aa)
	LOC101967418	Uncharacterized protein. (2364 aa)
	MC2R	Melanocortin 2 receptor. (296 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
	ENSSTOP00000025283	Uncharacterized protein; Belongs to the potassium channel family. (501 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
	PBX1	PBX homeobox 1. (430 aa)
	Gnas	Uncharacterized protein. (244 aa)
	CREB5	Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
	LOC101967288	Uncharacterized protein. (848 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1795 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
	ATF6B	Activating transcription factor 6 beta. (708 aa)
	LOC101959938	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
	ENSSTOP00000030023	BTB domain-containing protein; Belongs to the potassium channel family. (530 aa)
	ADCY8	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSSTOP00000007821	ENSSTOP00000004376	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.599
ADCY1	ADCY3	ENSSTOP00000007821	ENSSTOP00000005426	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.843
ADCY1	ADCY4	ENSSTOP00000007821	ENSSTOP00000002179	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.587
ADCY1	ADCY5	ENSSTOP00000007821	ENSSTOP00000000037	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.580
ADCY1	ADCY6	ENSSTOP00000007821	ENSSTOP00000003745	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.580
ADCY1	ADCY7	ENSSTOP00000007821	ENSSTOP00000028572	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.619
ADCY1	ADCY8	ENSSTOP00000007821	ENSSTOP00000030610	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.843
ADCY1	ADCY9	ENSSTOP00000007821	ENSSTOP00000004525	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.833
ADCY1	CACNA1G	ENSSTOP00000007821	ENSSTOP00000022216	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]	0.610
ADCY1	Gnas	ENSSTOP00000007821	ENSSTOP00000026819	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.851
ADCY1	LOC101967288	ENSSTOP00000007821	ENSSTOP00000027327	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.926
ADCY1	PDE8A	ENSSTOP00000007821	ENSSTOP00000013363	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.846
ADCY1	POMC	ENSSTOP00000007821	ENSSTOP00000005490	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Proopiomelanocortin.	0.437
ADCY1	PRKACA	ENSSTOP00000007821	ENSSTOP00000002080	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.889
ADCY1	PRKACB	ENSSTOP00000007821	ENSSTOP00000028928	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.892
ADCY1	PTRHD1	ENSSTOP00000007821	ENSSTOP00000005391	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.787
ADCY1	Pde8b	ENSSTOP00000007821	ENSSTOP00000032330	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.846
ADCY2	ADCY1	ENSSTOP00000004376	ENSSTOP00000007821	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.599
ADCY2	ADCY3	ENSSTOP00000004376	ENSSTOP00000005426	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.542
ADCY2	ADCY4	ENSSTOP00000004376	ENSSTOP00000002179	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.766