STRINGSTRING
ITPR2 ITPR2 PLCB4 PLCB4 LOC101968118 LOC101968118 TRPC5 TRPC5 ITPR3 ITPR3 PRKCG PRKCG PIK3R1 PIK3R1 KCNJ9 KCNJ9 ITPR1 ITPR1 PLCB2 PLCB2 KISS1 KISS1 LOC101975023 LOC101975023 CACNA1S CACNA1S AKT1 AKT1 HRAS HRAS TRPC4 TRPC4 Pik3r3 Pik3r3 TRPC1 TRPC1 Pik3cd Pik3cd CACNA1D CACNA1D ESR2 ESR2 KCNJ6 KCNJ6 PLCB3 PLCB3 Csde1 Csde1 GPER1 GPER1 KCNJ11 KCNJ11 SPP1 SPP1 CACNA1F CACNA1F Cacna1h Cacna1h GNAQ GNAQ KISS1R KISS1R Kcnn4 Kcnn4 NRAS NRAS LOC101965906 LOC101965906 PLCB1 PLCB1 CACNA1C CACNA1C MAPK1 MAPK1 KCNJ3 KCNJ3 LOC101978140 LOC101978140 PIK3CA PIK3CA PRKCB PRKCB Arr3 Arr3 KCNN1 KCNN1 AKT3 AKT3 LOC101962660 LOC101962660 KRAS KRAS MAP2K1 MAP2K1 HCN3 HCN3 HCN1 HCN1 GNRH1 GNRH1 GABBR2 GABBR2 HCN2 HCN2 PRKCA PRKCA AKT2 AKT2 GABBR1 GABBR1 Map2k2 Map2k2 Pik3r2 Pik3r2 PIK3CB PIK3CB MAPK3 MAPK3 CACNA1I CACNA1I KCNJ5 KCNJ5 CGA CGA Kcnn2 Kcnn2 ERAS ERAS GNA11 GNA11 CACNA1G CACNA1G KCNN3 KCNN3 LOC101967418 LOC101967418 ARRB2 ARRB2 ARRB1 ARRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (974 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2671 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (393 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2748 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
KISS1KiSS-1 metastasis suppressor. (135 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1795 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (977 aa)
Pik3r3Uncharacterized protein. (461 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (748 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
ESR2Estrogen receptor 2. (525 aa)
KCNJ6Potassium voltage-gated channel subfamily J member 6. (426 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
Csde1Uncharacterized protein. (555 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
SPP1Secreted phosphoprotein 1. (309 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1981 aa)
Cacna1hUncharacterized protein. (2259 aa)
GNAQG protein subunit alpha q. (313 aa)
KISS1RKISS1 receptor. (396 aa)
Kcnn4CaMBD domain-containing protein. (167 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (499 aa)
LOC101978140Luteinizing hormone beta subunit. (141 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
Arr3Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity). (393 aa)
KCNN1Potassium calcium-activated channel subfamily N member 1. (516 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (780 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (832 aa)
GNRH1Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. (92 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (822 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (838 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (984 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
Pik3r2Uncharacterized protein. (724 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
CACNA1ICalcium voltage-gated channel subunit alpha1 I. (1804 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
Kcnn2CaMBD domain-containing protein. (258 aa)
ERASES cell expressed Ras. (227 aa)
GNA11G protein subunit alpha 11. (359 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
KCNN3Potassium calcium-activated channel subfamily N member 3. (724 aa)
LOC101967418Uncharacterized protein. (2364 aa)
ARRB2Arrestin beta 2. (409 aa)
ARRB1Arrestin beta 1. (418 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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