STRINGSTRING
HK1 HK1 HKDC1 HKDC1 MAPK3 MAPK3 INSR INSR PIK3CB PIK3CB MAPK10 MAPK10 Pik3r2 Pik3r2 HK2 HK2 GCK GCK TNIK TNIK HK3 HK3 SOCS4 SOCS4 PRKCD PRKCD CACNA1B CACNA1B IKBKB IKBKB PARP8 PARP8 PARP6 PARP6 SLC2A4 SLC2A4 CACNA1E CACNA1E LOC101962660 LOC101962660 SLC2A2 SLC2A2 SOCS3 SOCS3 SOCS2 SOCS2 CRADD CRADD PRKCE PRKCE MAPK8 MAPK8 TNF TNF PIK3CA PIK3CA MAPK1 MAPK1 CACNA1C CACNA1C ADIPOQ ADIPOQ LOC101965906 LOC101965906 Ins Ins KCNJ11 KCNJ11 LOC101975126 LOC101975126 IRS1 IRS1 SOCS1 SOCS1 MAFA MAFA PDX1 PDX1 CACNA1G CACNA1G IRS4 IRS4 LOC101968118 LOC101968118 PIK3R1 PIK3R1 CACNA1A CACNA1A Pik3r3 Pik3r3 Pik3cd Pik3cd CACNA1D CACNA1D PKLR PKLR MAPK9 MAPK9 PKM PKM MTOR MTOR ABCC8 ABCC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HK1Hexokinase 1. (920 aa)
HKDC1Hexokinase domain containing 1. (917 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
HK2Hexokinase 2. (917 aa)
GCKPhosphotransferase. (467 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
HK3Hexokinase 3. (867 aa)
SOCS4Suppressor of cytokine signaling 4. (439 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2316 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PARP8Poly [ADP-ribose] polymerase. (893 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2312 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa)
SOCS3Suppressor of cytokine signaling 3. (227 aa)
SOCS2Suppressor of cytokine signaling 2. (159 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2193 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
LOC101975126Uncharacterized protein. (498 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
MAFAMAF bZIP transcription factor A. (360 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2379 aa)
IRS4Insulin receptor substrate 4. (1228 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2092 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2179 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (565 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
ABCC8ATP binding cassette subfamily C member 8. (1624 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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