STRINGSTRING
TBC1D4 TBC1D4 PPP1R3G PPP1R3G I3MVL6_ICTTR I3MVL6_ICTTR GFPT1 GFPT1 PTEN PTEN SLC27A2 SLC27A2 PPP1R3A PPP1R3A PPP1R3D PPP1R3D LOC101965906 LOC101965906 CREB3L3 CREB3L3 CREB1 CREB1 PCK1 PCK1 PRKAG1 PRKAG1 CREB3L4 CREB3L4 PYGB PYGB GYS1 GYS1 CPT1B CPT1B NFU1 NFU1 PDPK1 PDPK1 PIK3CA PIK3CA TNF TNF CPT1A CPT1A CREB3L1 CREB3L1 MAPK8 MAPK8 PRKCE PRKCE OGT OGT PYGL PYGL NFKB1 NFKB1 PPARA PPARA SOCS3 SOCS3 AKT3 AKT3 RPS6KA3 RPS6KA3 SLC2A2 SLC2A2 PRKAA2 PRKAA2 TNFRSF1A TNFRSF1A CREB3L2 CREB3L2 LOC101962660 LOC101962660 Foxo1 Foxo1 PPP1CC PPP1CC PRKAB1 PRKAB1 SLC2A4 SLC2A4 TRIB3 TRIB3 NFKBIA NFKBIA PCK2 PCK2 G6PC2 G6PC2 G6PC3 G6PC3 NOSTRIN NOSTRIN STAT3 STAT3 PRKAG3 PRKAG3 GYS2 GYS2 IKBKB IKBKB RPS6KA2 RPS6KA2 CREB3 CREB3 ACACB ACACB I3M4W8_ICTTR I3M4W8_ICTTR PRKCD PRKCD SLC27A5 SLC27A5 MLX MLX AKT2 AKT2 TNIK TNIK GFPT2 GFPT2 Pik3r2 Pik3r2 MAPK10 MAPK10 MLXIP MLXIP PTPA PTPA PIK3CB PIK3CB INSR INSR MTOR MTOR SLC27A6 SLC27A6 RPS6KA1 RPS6KA1 RPS6KA6 RPS6KA6 PRKAB2 PRKAB2 NOS3 NOS3 MAPK9 MAPK9 ENSSTOP00000030497 ENSSTOP00000030497 PPARGC1B PPARGC1B Pik3cd Pik3cd SREBF1 SREBF1 Pik3r3 Pik3r3 AKT1 AKT1 NR1H2 NR1H2 NR1H3 NR1H3 PPP1R3E PPP1R3E PTPRS PTPRS SLC2A1 SLC2A1 PRKAG2 PRKAG2 CREB5 CREB5 LOC101978624 LOC101978624 PPARGC1A PPARGC1A PPP1CA PPP1CA PIK3R1 PIK3R1 CD36 CD36 PTPRF PTPRF Oga Oga LOC101968118 LOC101968118 PYGM PYGM PRKAA1 PRKAA1 CRTC2 CRTC2 GSK3B GSK3B Rps6kb1 Rps6kb1 PPP1R3B PPP1R3B SLC27A3 SLC27A3 PTPN1 PTPN1 PTPN11 PTPN11 SLC27A4 SLC27A4 LOC101974931 LOC101974931 PRKCQ PRKCQ LOC101960206 LOC101960206 SLC27A1 SLC27A1 MLXIPL MLXIPL IRS1 IRS1 I3N090_ICTTR I3N090_ICTTR PPP1CB PPP1CB RELA RELA PPP1R3C PPP1R3C Ins Ins AGT AGT RPS6KB2 RPS6KB2 G6PC G6PC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBC1D4TBC1 domain family member 4. (1299 aa)
PPP1R3GProtein phosphatase 1 regulatory subunit 3G. (334 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (699 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SLC27A2Solute carrier family 27 member 2. (620 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1110 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (284 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CREB3L3cAMP responsive element binding protein 3 like 3. (442 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
CREB3L4cAMP responsive element binding protein 3 like 4. (394 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (649 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (254 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (556 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (519 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SOCS3Suppressor of cytokine signaling 3. (227 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (521 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (522 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
G6PC3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (346 aa)
NOSTRINNitric oxide synthase trafficking. (505 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (490 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
CREB3cAMP responsive element binding protein 3. (374 aa)
ACACBAcetyl-CoA carboxylase beta. (2328 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
SLC27A5Solute carrier family 27 member 5. (690 aa)
MLXMAX dimerization protein MLX. (294 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
GFPT2Glutamine-fructose-6-phosphate transaminase 2. (682 aa)
Pik3r2Uncharacterized protein. (724 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
MLXIPMLX interacting protein. (850 aa)
PTPASerine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (288 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
INSRTyrosine-protein kinase receptor. (1359 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2577 aa)
SLC27A6Solute carrier family 27 member 6. (619 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
RPS6KA6Ribosomal protein S6 kinase. (830 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000030497SER_THR_PHOSPHATASE domain-containing protein. (298 aa)
PPARGC1BPPARG coactivator 1 beta. (1033 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1152 aa)
Pik3r3Uncharacterized protein. (461 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (444 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (282 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1855 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (542 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (467 aa)
LOC101978624Uncharacterized protein. (906 aa)
PPARGC1APPARG coactivator 1 alpha. (803 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CD36CD36 molecule; Belongs to the CD36 family. (473 aa)
PTPRFProtein tyrosine phosphatase receptor type F. (1908 aa)
OgaUncharacterized protein. (565 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
PRKAA1Non-specific serine/threonine protein kinase. (561 aa)
CRTC2CREB regulated transcription coactivator 2. (693 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
Rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (284 aa)
SLC27A3Solute carrier family 27 member 3. (667 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (413 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
SLC27A4Solute carrier family 27 member 4. (643 aa)
LOC101974931Tyrosine-protein phosphatase non-receptor type. (433 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LOC101960206Uncharacterized protein. (207 aa)
SLC27A1Solute carrier family 27 member 1. (577 aa)
MLXIPLMLX interacting protein like. (817 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (318 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
InsInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (485 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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