STRINGSTRING
Casp3 Casp3 COL4A4 COL4A4 CCND1 CCND1 EDN1 EDN1 SERPINE1 SERPINE1 NOX3 NOX3 Cdc42 Cdc42 MAPK3 MAPK3 Cdk4 Cdk4 TGFB2 TGFB2 PIK3CB PIK3CB PLCD1 PLCD1 MAPK10 MAPK10 Pik3r2 Pik3r2 IL1A IL1A IL1B IL1B VEGFC VEGFC FN1 FN1 AKT2 AKT2 PRKCA PRKCA CXCL8 CXCL8 SMAD2 SMAD2 COL4A6 COL4A6 COL4A1 COL4A1 F3 F3 PRKCD PRKCD I3M4W8_ICTTR I3M4W8_ICTTR NOX1 NOX1 PLCG2 PLCG2 VEGFD VEGFD JAK2 JAK2 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 RAC1 RAC1 NFATC1 NFATC1 NOX4 NOX4 STAT1 STAT1 VEGFA VEGFA SELE SELE PLCD3 PLCD3 KRAS KRAS Foxo1 Foxo1 LOC101962660 LOC101962660 TGFB1 TGFB1 SMAD3 SMAD3 AKT3 AKT3 COL1A2 COL1A2 NFKB1 NFKB1 PLCG1 PLCG1 PRKCB PRKCB PRKCE PRKCE MAPK8 MAPK8 TNF TNF PIK3CA PIK3CA TGFBR1 TGFBR1 BAX BAX VEGFB VEGFB MAPK1 MAPK1 MAPK12 MAPK12 MAPK11 MAPK11 PLCB1 PLCB1 LOC101965906 LOC101965906 CDKN1B CDKN1B NRAS NRAS PLCE1 PLCE1 BCL2 BCL2 I3MVL6_ICTTR I3MVL6_ICTTR EGR1 EGR1 MMP2 MMP2 SMAD4 SMAD4 AGT AGT AGTR1 AGTR1 RELA RELA I3N090_ICTTR I3N090_ICTTR LOC101960206 LOC101960206 Vcam1 Vcam1 XK XK I3N4S4_ICTTR I3N4S4_ICTTR COL4A2 COL4A2 PIM1 PIM1 ERAS ERAS JUN JUN LOC101969207 LOC101969207 TGFB3 TGFB3 CYBB CYBB MAPK14 MAPK14 MAPK13 MAPK13 ENSSTOP00000024190 ENSSTOP00000024190 PLCD4 PLCD4 PLCB4 PLCB4 LOC101968118 LOC101968118 TGFBR2 TGFBR2 AGER AGER COL1A1 COL1A1 PIK3R1 PIK3R1 ICAM1 ICAM1 PLCB2 PLCB2 LOC101975023 LOC101975023 AKT1 AKT1 HRAS HRAS MFF MFF Pik3r3 Pik3r3 Pik3cd Pik3cd MAPK9 MAPK9 PLCB3 PLCB3 NOS3 NOS3 Csde1 Csde1 COL3A1 COL3A1 ENSSTOP00000031310 ENSSTOP00000031310 LOC101966144 LOC101966144
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
COL4A4Collagen type IV alpha 4 chain. (1583 aa)
CCND1Cyclin D1. (250 aa)
EDN1Endothelin 1. (202 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
NOX3NADPH oxidase 3. (567 aa)
Cdc42Uncharacterized protein. (191 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
Cdk4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (417 aa)
FN1Fibronectin 1. (2474 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
COL4A6Collagen type IV alpha 6 chain. (1686 aa)
COL4A1Collagen type IV alpha 1 chain. (1671 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (293 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
NOX1NADPH oxidase 1. (561 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (359 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
STAT5BSignal transducer and activator of transcription. (765 aa)
STAT5ASignal transducer and activator of transcription. (773 aa)
STAT3Signal transducer and activator of transcription. (748 aa)
RAC1Rac family small GTPase 1. (211 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
NOX4NADPH oxidase 4. (578 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (392 aa)
SELESelectin E. (495 aa)
PLCD3Phosphoinositide phospholipase C. (782 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
Foxo1Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (535 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
COL1A2Collagen type I alpha 2 chain. (1366 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (184 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
PLCE1Phosphoinositide phospholipase C. (2298 aa)
BCL2BCL2 apoptosis regulator. (195 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MMP2Matrix metallopeptidase 2. (662 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
LOC101960206Uncharacterized protein. (207 aa)
Vcam1Vascular cell adhesion molecule 1. (657 aa)
XKXK-related protein. (443 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
ERASES cell expressed Ras. (227 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
LOC101969207C-C motif chemokine. (136 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
ENSSTOP00000024190Protein kinase domain-containing protein. (266 aa)
PLCD4Phosphoinositide phospholipase C. (783 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
AGERAdvanced glycosylation end-product specific receptor. (450 aa)
COL1A1Collagen type I alpha 1 chain. (1268 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ICAM1Intercellular adhesion molecule 1. (531 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
LOC101975023CSD_1 domain-containing protein. (729 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
MFFMitochondrial fission factor. (316 aa)
Pik3r3Uncharacterized protein. (461 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1228 aa)
Csde1Uncharacterized protein. (555 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
LOC101966144Uncharacterized protein. (147 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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