(40 nodes) Aldosterone-regulated sodium reabsorption network (Ictidomys tridecemlineatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MAPK3	Mitogen-activated protein kinase. (361 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
	ATP1A1	Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
	LOC101954605	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (271 aa)
	IGF1	Insulin like growth factor 1. (166 aa)
	Pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
	Pik3r3	Uncharacterized protein. (461 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
	FXYD4	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (88 aa)
	ATP1A2	Sodium/potassium-transporting ATPase subunit alpha. (1023 aa)
	LOC101968118	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
	I3NC46_ICTTR	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (397 aa)
	ATP1B2	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
	Ins	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	Fxyd2	FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (64 aa)
	LOC101965906	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
	Sgk1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (454 aa)
	HSD11B2	Hydroxysteroid 11-beta dehydrogenase 2. (398 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (248 aa)
	MAPK1	Mitogen-activated protein kinase. (331 aa)
	SCNN1A	Sodium channel epithelial 1 alpha subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (668 aa)
	Atp1b3	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (265 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (556 aa)
	SLC9A3R2	SLC9A3 regulator 2. (226 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	NEDD4L	NEDD4 like E3 ubiquitin protein ligase. (962 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (668 aa)
	ATP1B1	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
	LOC101962660	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
	ATP1A4	Sodium/potassium-transporting ATPase subunit alpha. (987 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (649 aa)
	NR3C2	Nuclear receptor subfamily 3 group C member 2. (985 aa)
	Atp1a3	Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
	KCNJ1	Potassium voltage-gated channel subfamily J member 1. (391 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (603 aa)
	ATP1B4	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (353 aa)
	Pik3r2	Uncharacterized protein. (724 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	INSR	Tyrosine-protein kinase receptor. (1359 aa)

Your Current Organism:

Ictidomys tridecemlineatus

NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP1A1	ATP1A2	ENSSTOP00000031415	ENSSTOP00000025067	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.917
ATP1A1	ATP1A4	ENSSTOP00000031415	ENSSTOP00000006727	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.894
ATP1A1	ATP1B1	ENSSTOP00000031415	ENSSTOP00000010292	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.993
ATP1A1	ATP1B2	ENSSTOP00000031415	ENSSTOP00000017627	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.959
ATP1A1	ATP1B4	ENSSTOP00000031415	ENSSTOP00000002067	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.937
ATP1A1	Atp1a3	ENSSTOP00000031415	ENSSTOP00000003626	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.927
ATP1A1	Atp1b3	ENSSTOP00000031415	ENSSTOP00000011861	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.823
ATP1A1	FXYD4	ENSSTOP00000031415	ENSSTOP00000025614	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.514
ATP1A1	Fxyd2	ENSSTOP00000031415	ENSSTOP00000015976	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.982
ATP1A1	LOC101954605	ENSSTOP00000031415	ENSSTOP00000031198	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.965
ATP1A1	MAPK1	ENSSTOP00000031415	ENSSTOP00000013254	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.819
ATP1A1	MAPK3	ENSSTOP00000031415	ENSSTOP00000000787	Sodium/potassium-transporting ATPase subunit alpha.	Mitogen-activated protein kinase.	0.819
ATP1A2	ATP1A1	ENSSTOP00000025067	ENSSTOP00000031415	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.917
ATP1A2	ATP1A4	ENSSTOP00000025067	ENSSTOP00000006727	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.894
ATP1A2	ATP1B1	ENSSTOP00000025067	ENSSTOP00000010292	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.992
ATP1A2	ATP1B2	ENSSTOP00000025067	ENSSTOP00000017627	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.968
ATP1A2	ATP1B4	ENSSTOP00000025067	ENSSTOP00000002067	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.938
ATP1A2	Atp1a3	ENSSTOP00000025067	ENSSTOP00000003626	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit alpha.	0.929
ATP1A2	Atp1b3	ENSSTOP00000025067	ENSSTOP00000011861	Sodium/potassium-transporting ATPase subunit alpha.	Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.	0.823
ATP1A2	FXYD4	ENSSTOP00000025067	ENSSTOP00000025614	Sodium/potassium-transporting ATPase subunit alpha.	FXYD domain-containing ion transport regulator; Belongs to the FXYD family.	0.514