STRINGSTRING
JUN JUN MAPK14 MAPK14 CALM2 CALM2 MAPK13 MAPK13 TMED3 TMED3 ENSSTOP00000025043 ENSSTOP00000025043 IRAK1 IRAK1 ENSSTOP00000025426 ENSSTOP00000025426 C1QC C1QC SERPING1 SERPING1 LOC101977784 LOC101977784 CALM3 CALM3 CXCL6 CXCL6 Tmed7 Tmed7 ENSSTOP00000029069 ENSSTOP00000029069 Cfl1 Cfl1 ENSSTOP00000029727 ENSSTOP00000029727 ENSSTOP00000029937 ENSSTOP00000029937 C2 C2 MAPK9 MAPK9 ENSSTOP00000031001 ENSSTOP00000031001 ENSSTOP00000031310 ENSSTOP00000031310 C1QA C1QA ENSSTOP00000032237 ENSSTOP00000032237 RELA RELA IL1B IL1B C1R C1R FOS FOS CASP7 CASP7 ITGAM ITGAM CXCL8 CXCL8 Casp3 Casp3 Rhoa Rhoa I3M4W8_ICTTR I3M4W8_ICTTR IL12B IL12B IL10 IL10 C4BPA C4BPA TRAF6 TRAF6 MAPK3 MAPK3 ITGA5 ITGA5 CALML3 CALML3 GNAI3 GNAI3 IRF1 IRF1 TIRAP TIRAP NLRP3 NLRP3 EFCAB3 EFCAB3 NFKB1 NFKB1 GNAI1 GNAI1 MAPK8 MAPK8 TNF TNF C5 C5 PYCARD PYCARD ITGB1 ITGB1 MYD88 MYD88 Irak4 Irak4 IL12A IL12A C4a C4a MAPK1 MAPK1 C1S C1S MAPK12 MAPK12 MAPK11 MAPK11 CALML4 CALML4 IL23A IL23A GNAI2 GNAI2 CALM1 CALM1 NOD1 NOD1 I3MVL6_ICTTR I3MVL6_ICTTR CALML6 CALML6 C1QB C1QB CD14 CD14 NOS2 NOS2 IL1A IL1A TLR4 TLR4 I3N090_ICTTR I3N090_ICTTR LOC101960206 LOC101960206 IRF3 IRF3 LOC101959358 LOC101959358 Rhoc Rhoc I3N6Q6_ICTTR I3N6Q6_ICTTR CCDC125 CCDC125 IRF8 IRF8 TICAM2 TICAM2 ITGB2 ITGB2 Cfl2 Cfl2 MAPK10 MAPK10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
CALM2Calmodulin 2; Belongs to the calmodulin family. (149 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
TMED3Transmembrane p24 trafficking protein 3. (215 aa)
ENSSTOP00000025043Uncharacterized protein. (518 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
ENSSTOP00000025426A2M_N_2 domain-containing protein. (103 aa)
C1QCComplement C1q C chain. (245 aa)
SERPING1Serpin family G member 1; Belongs to the serpin family. (474 aa)
LOC101977784C-type lectin domain-containing protein. (248 aa)
CALM3Calmodulin 3. (149 aa)
CXCL6C-X-C motif chemokine. (129 aa)
Tmed7GOLD domain-containing protein. (225 aa)
ENSSTOP00000029069EF-hand domain-containing protein. (222 aa)
Cfl1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (203 aa)
ENSSTOP00000029727ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (152 aa)
ENSSTOP00000029937Uncharacterized protein; Belongs to the calmodulin family. (67 aa)
C2Complement C2; Belongs to the peptidase S1 family. (770 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
ENSSTOP00000031310Uncharacterized protein; Belongs to the peptidase C14A family. (233 aa)
C1QAComplement C1q A chain. (240 aa)
ENSSTOP00000032237Uncharacterized protein; Belongs to the calmodulin family. (148 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (705 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (303 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1120 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
Casp3Uncharacterized protein; Belongs to the peptidase C14A family. (277 aa)
RhoaRas homolog family member A. (193 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
IL10Interleukin 10. (178 aa)
C4BPAComplement component 4 binding protein alpha. (540 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
GNAI3G protein subunit alpha i3. (354 aa)
IRF1Interferon regulatory factor. (326 aa)
TIRAPTIR domain containing adaptor protein. (222 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
EFCAB3EF-hand calcium binding domain 3. (432 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
GNAI1G protein subunit alpha i1. (354 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
C5Complement C5. (1643 aa)
PYCARDPYD and CARD domain containing. (194 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
C4aUncharacterized protein. (1744 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
C1SComplement C1s; Belongs to the peptidase S1 family. (695 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CALML4Calmodulin like 4. (153 aa)
IL23AInterleukin 23 subunit alpha. (185 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CALM1Calmodulin 1; Belongs to the calmodulin family. (148 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (951 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
CALML6Calmodulin like 6. (172 aa)
C1QBComplement C1q B chain. (246 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (373 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
LOC101960206Uncharacterized protein. (207 aa)
IRF3Interferon regulatory factor 3. (420 aa)
LOC101959358Uncharacterized protein. (193 aa)
RhocUncharacterized protein. (193 aa)
I3N6Q6_ICTTRADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (160 aa)
CCDC125Coiled-coil domain containing 125. (512 aa)
IRF8Interferon regulatory factor 8. (423 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
ITGB2Integrin beta. (769 aa)
Cfl2ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (167 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.