STRINGSTRING
MAP2K3 MAP2K3 MAP2K1 MAP2K1 ARHGEF28 ARHGEF28 WIPF3 WIPF3 CRKL CRKL TBK1 TBK1 NFATC1 NFATC1 ITGA5 ITGA5 NFKBIA NFKBIA PKN2 PKN2 TRAF6 TRAF6 Actg1 Actg1 RAC1 RAC1 IL10 IL10 ELMO1 ELMO1 IKBKB IKBKB RPS6KA2 RPS6KA2 I3M4W8_ICTTR I3M4W8_ICTTR GIT2 GIT2 Rhoa Rhoa Wipf1 Wipf1 BCAR1 BCAR1 ARHGEF1 ARHGEF1 CXCL8 CXCL8 WASF2 WASF2 FOS FOS AKT2 AKT2 FN1 FN1 Map2k2 Map2k2 IL1B IL1B Pik3r2 Pik3r2 WASL WASL MAPK10 MAPK10 PIK3CB PIK3CB MAPK3 MAPK3 Cdc42 Cdc42 PIP5K1A PIP5K1A TAB1 TAB1 VAV3 VAV3 ROCK2 ROCK2 MAP3K7 MAP3K7 BAIAP2 BAIAP2 RPS6KA1 RPS6KA1 RPS6KA6 RPS6KA6 ENSSTOP00000031475 ENSSTOP00000031475 LOC101966144 LOC101966144 PTK2 PTK2 PIP5K1C PIP5K1C WIPF2 WIPF2 ENSSTOP00000031001 ENSSTOP00000031001 MAPK9 MAPK9 MAP2K7 MAP2K7 ENSSTOP00000030397 ENSSTOP00000030397 PTK2B PTK2B ACTR2 ACTR2 Pik3cd Pik3cd Pik3r3 Pik3r3 NFATC2 NFATC2 AKT1 AKT1 ACTR3B ACTR3B ENSSTOP00000028111 ENSSTOP00000028111 ARHGEF7 ARHGEF7 ENSSTOP00000027636 ENSSTOP00000027636 IKBKG IKBKG PIK3R1 PIK3R1 LAT LAT PKN1 PKN1 IRAK1 IRAK1 LOC101968118 LOC101968118 CRK CRK DOCK1 DOCK1 NLRC4 NLRC4 MAPK13 MAPK13 GSK3B GSK3B MAPK14 MAPK14 ARF6 ARF6 CD4 CD4 PIP5K1B PIP5K1B LOC101969207 LOC101969207 VAV2 VAV2 I3NCC6_ICTTR I3NCC6_ICTTR JUN JUN SKAP2 SKAP2 WAS WAS LOC101968765 LOC101968765 Rhoc Rhoc ROCK1 ROCK1 I3N4S4_ICTTR I3N4S4_ICTTR ACTL7B ACTL7B ACTRT1 ACTRT1 LOC101959358 LOC101959358 IRF3 IRF3 LOC101960206 LOC101960206 MAP2K4 MAP2K4 ACTL8 ACTL8 LOC101971713 LOC101971713 I3N090_ICTTR I3N090_ICTTR TLR4 TLR4 RELA RELA LOC101954496 LOC101954496 RAC2 RAC2 RHOG RHOG ACTRT2 ACTRT2 ACTL7A ACTL7A I3MVL6_ICTTR I3MVL6_ICTTR NFATC3 NFATC3 TAB2 TAB2 IL18 IL18 I3MSG9_ICTTR I3MSG9_ICTTR LOC101965906 LOC101965906 LCP2 LCP2 CHUK CHUK IL2 IL2 ARHGEF12 ARHGEF12 LPXN LPXN MAPK11 MAPK11 MAPK12 MAPK12 Actb Actb MAPK1 MAPK1 PXN PXN RAC3 RAC3 Irak4 Irak4 MYD88 MYD88 ITGB1 ITGB1 PYCARD PYCARD I3MKE3_ICTTR I3MKE3_ICTTR PIK3CA PIK3CA TNF TNF ELMO2 ELMO2 LIMK1 LIMK1 MAPK8 MAPK8 TRAF2 TRAF2 PLCG1 PLCG1 NFKB1 NFKB1 CD8A CD8A ACTR3 ACTR3 ZAP70 ZAP70 VAV1 VAV1 AKT3 AKT3 RPS6KA3 RPS6KA3 ACTL9 ACTL9 NLRP3 NLRP3 ITGA4 ITGA4 LOC101962660 LOC101962660
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1704 aa)
WIPF3WAS/WASL interacting protein family member 3. (442 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TBK1TANK binding kinase 1. (729 aa)
NFATC1Nuclear factor of activated T cells 1. (941 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1105 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
PKN2Protein kinase N2. (982 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
Actg1Uncharacterized protein. (375 aa)
RAC1Rac family small GTPase 1. (211 aa)
IL10Interleukin 10. (178 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
GIT2GIT ArfGAP 2. (752 aa)
RhoaRas homolog family member A. (193 aa)
Wipf1WH2 domain-containing protein. (58 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (874 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (972 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
WASF2WASP family member 2. (497 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FN1Fibronectin 1. (2474 aa)
Map2k2Mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (498 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
Pik3r2Uncharacterized protein. (724 aa)
WASLWASP like actin nucleation promoting factor. (504 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
Cdc42Uncharacterized protein. (191 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (537 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
BAIAP2BAI1 associated protein 2. (535 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
RPS6KA6Ribosomal protein S6 kinase. (830 aa)
ENSSTOP00000031475Uncharacterized protein; Belongs to the actin family. (173 aa)
LOC101966144Uncharacterized protein. (147 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1137 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
WIPF2WAS/WASL interacting protein family member 2. (439 aa)
ENSSTOP00000031001Uncharacterized protein. (178 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (469 aa)
ENSSTOP00000030397Uncharacterized protein; Belongs to the actin family. (148 aa)
PTK2BProtein tyrosine kinase 2 beta. (968 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
Pik3r3Uncharacterized protein. (461 aa)
NFATC2Nuclear factor of activated T cells 2. (844 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (417 aa)
ENSSTOP00000028111Ig-like domain-containing protein. (135 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (713 aa)
ENSSTOP00000027636Ig-like domain-containing protein. (165 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
LATLinker for activation of T cells. (234 aa)
PKN1Protein kinase N1. (947 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1849 aa)
NLRC4NLR family CARD domain containing 4. (841 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
CD4CD4 molecule. (451 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (452 aa)
LOC101969207C-C motif chemokine. (136 aa)
VAV2Vav guanine nucleotide exchange factor 2. (745 aa)
I3NCC6_ICTTRUncharacterized protein; Belongs to the actin family. (340 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
SKAP2Src kinase associated phosphoprotein 2. (359 aa)
WASWASP actin nucleation promoting factor. (503 aa)
LOC101968765Uncharacterized protein. (187 aa)
RhocUncharacterized protein. (193 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
I3N4S4_ICTTRUncharacterized protein. (162 aa)
ACTL7BActin like 7B; Belongs to the actin family. (418 aa)
ACTRT1Actin related protein T1; Belongs to the actin family. (377 aa)
LOC101959358Uncharacterized protein. (193 aa)
IRF3Interferon regulatory factor 3. (420 aa)
LOC101960206Uncharacterized protein. (207 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
LOC101971713Uncharacterized protein; Belongs to the actin family. (1238 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LOC101954496Uncharacterized protein. (346 aa)
RAC2Rac family small GTPase 2. (192 aa)
RHOGRas homolog family member G. (191 aa)
ACTRT2Actin related protein T2; Belongs to the actin family. (435 aa)
ACTL7AActin like 7A; Belongs to the actin family. (440 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
NFATC3Nuclear factor of activated T cells 3. (1075 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
I3MSG9_ICTTRIg-like domain-containing protein. (186 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1518 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
ActbActin beta. (375 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
PXNPaxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (424 aa)
RAC3Rac family small GTPase 3. (185 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
PYCARDPYD and CARD domain containing. (194 aa)
I3MKE3_ICTTRUncharacterized protein. (721 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
LIMK1LIM domain kinase 1. (628 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1290 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
CD8ACD8a molecule. (238 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ZAP70Tyrosine-protein kinase. (608 aa)
VAV1Vav guanine nucleotide exchange factor 1. (822 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
ACTL9Actin like 9; Belongs to the actin family. (415 aa)
NLRP3NLR family pyrin domain containing 3. (1035 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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