STRINGSTRING
IL1A IL1A NCF2 NCF2 IFNGR2 IFNGR2 MAPK3 MAPK3 TGFB2 TGFB2 ITGB2 ITGB2 IL1B IL1B TAB1 TAB1 FOS FOS ITGAM ITGAM HLA-DOB HLA-DOB HLA-DPA1 HLA-DPA1 HLA-DPB1 HLA-DPB1 Fcgr3a Fcgr3a IL12B IL12B IL10 IL10 NCF1 NCF1 JAK2 JAK2 TRAF6 TRAF6 NFKBIA NFKBIA Eef1a1 Eef1a1 STAT1 STAT1 HLA-DMA HLA-DMA Ptgs2 Ptgs2 HLA-DQB1 HLA-DQB1 LOC101968486 LOC101968486 LOC101968188 LOC101968188 ITGA4 ITGA4 TGFB1 TGFB1 ELK1 ELK1 HLA-DRA HLA-DRA HLA-DOA HLA-DOA NFKB1 NFKB1 MARCKSL1 MARCKSL1 TNF TNF ITGB1 ITGB1 MYD88 MYD88 Irak4 Irak4 IL12A IL12A MAPK1 MAPK1 IFNG IFNG MAPK12 MAPK12 MAPK11 MAPK11 LOC101970595 LOC101970595 I3MSG9_ICTTR I3MSG9_ICTTR TAB2 TAB2 Ncf4 Ncf4 NOS2 NOS2 RELA RELA IFNGR1 IFNGR1 TLR4 TLR4 NFKBIB NFKBIB EEF1A2 EEF1A2 FAM229A FAM229A JAK1 JAK1 LOC101957991 LOC101957991 LOC101959667 LOC101959667 JUN JUN TLR2 TLR2 TGFB3 TGFB3 LOC101966442 LOC101966442 CYBB CYBB MAPK14 MAPK14 MAPK13 MAPK13 NOXA1 NOXA1 I3NHR2_ICTTR I3NHR2_ICTTR CYBA CYBA IRAK1 IRAK1 ENSSTOP00000027636 ENSSTOP00000027636 ENSSTOP00000028111 ENSSTOP00000028111 ENSSTOP00000028274 ENSSTOP00000028274 ENSSTOP00000029279 ENSSTOP00000029279 ENSSTOP00000029387 ENSSTOP00000029387 PTPN6 PTPN6 LOC101970873 LOC101970873 ENSSTOP00000032295 ENSSTOP00000032295 MAP3K7 MAP3K7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1AInterleukin-1; Belongs to the IL-1 family. (268 aa)
NCF2Neutrophil cytosolic factor 2. (525 aa)
IFNGR2Interferon gamma receptor 2. (306 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ITGB2Integrin beta. (769 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (502 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ITGAMIntegrin subunit alpha M; Belongs to the integrin alpha chain family. (1120 aa)
HLA-DOBMajor histocompatibility complex, class II, DO beta. (282 aa)
HLA-DPA1Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family. (254 aa)
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (288 aa)
Fcgr3aUncharacterized protein. (253 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
IL10Interleukin 10. (178 aa)
NCF1Neutrophil cytosolic factor 1. (405 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
Eef1a1Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
HLA-DMAMajor histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (292 aa)
Ptgs2EGF-like domain-containing protein. (605 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 1. (269 aa)
LOC101968486Ig-like domain-containing protein; Belongs to the MHC class II family. (255 aa)
LOC101968188Ig-like domain-containing protein. (266 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ELK1ETS transcription factor ELK1. (428 aa)
HLA-DRAMajor histocompatibility complex, class II, DR alpha; Belongs to the MHC class II family. (254 aa)
HLA-DOAMajor histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (220 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
MARCKSL1MARCKS like 1. (178 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (798 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
LOC101970595Ig-like domain-containing protein. (264 aa)
I3MSG9_ICTTRIg-like domain-containing protein. (186 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (692 aa)
Ncf4Neutrophil cytosolic factor 4. (294 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
NFKBIBNFKB inhibitor beta. (359 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (426 aa)
FAM229AFamily with sequence similarity 229 member A. (130 aa)
JAK1Tyrosine-protein kinase. (1142 aa)
LOC101957991Ig-like domain-containing protein. (249 aa)
LOC101959667Ig-like domain-containing protein. (272 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC101966442Uncharacterized protein. (370 aa)
CYBBCytochrome b-245 beta chain. (549 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
NOXA1NADPH oxidase activator 1. (492 aa)
I3NHR2_ICTTRUncharacterized protein. (435 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (195 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
ENSSTOP00000027636Ig-like domain-containing protein. (165 aa)
ENSSTOP00000028111Ig-like domain-containing protein. (135 aa)
ENSSTOP00000028274Tr-type G domain-containing protein. (113 aa)
ENSSTOP00000029279Tr-type G domain-containing protein. (419 aa)
ENSSTOP00000029387Tr-type G domain-containing protein. (422 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LOC101970873Ig-like domain-containing protein. (251 aa)
ENSSTOP00000032295Uncharacterized protein. (488 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.