STRINGSTRING
TLR2 TLR2 AKT3 AKT3 CASP8 CASP8 NFKB1 NFKB1 GNAL GNAL MAPK1 MAPK1 IFNG IFNG MAPK12 MAPK12 MAPK11 MAPK11 CCL5 CCL5 IL2 IL2 PLCB1 PLCB1 GNAI2 GNAI2 CHUK CHUK LOC101965906 LOC101965906 GNAQ GNAQ I3MVL6_ICTTR I3MVL6_ICTTR CD3D CD3D C1QB C1QB BDKRB2 BDKRB2 NOS2 NOS2 RELA RELA IFNGR1 IFNGR1 TLR4 TLR4 PPP2R2A PPP2R2A I3N090_ICTTR I3N090_ICTTR MAP2K4 MAP2K4 LOC101960206 LOC101960206 KNG1 KNG1 LOC101960961 LOC101960961 CD247 CD247 LOC101968765 LOC101968765 GNA11 GNA11 CASP10 CASP10 JUN JUN PPP2CA PPP2CA LOC101969207 LOC101969207 TGFB3 TGFB3 GNA15 GNA15 MAPK14 MAPK14 LOC101968434 LOC101968434 MAPK13 MAPK13 LOC101961439 LOC101961439 PLCB4 PLCB4 FADD FADD LOC101968118 LOC101968118 TGFBR2 TGFBR2 CFLAR CFLAR IRAK1 IRAK1 C1QC C1QC PIK3R1 PIK3R1 PPP2R1B PPP2R1B Gnas Gnas IKBKG IKBKG PLCB2 PLCB2 LOC101967288 LOC101967288 Ppp2cb Ppp2cb ENSSTOP00000027631 ENSSTOP00000027631 AKT1 AKT1 Pik3r3 Pik3r3 PPP2R2C PPP2R2C Pik3cd Pik3cd PPP2R2B PPP2R2B MAPK9 MAPK9 PLCB3 PLCB3 C1QA C1QA ENSSTOP00000032383 ENSSTOP00000032383 LOC101967545 LOC101967545 IFNGR2 IFNGR2 SERPINE1 SERPINE1 MAPK3 MAPK3 IL12A IL12A Irak4 Irak4 MYD88 MYD88 TGFBR1 TGFBR1 LOC101968303 LOC101968303 PIK3CA PIK3CA GNAI1 GNAI1 TNF TNF MAPK8 MAPK8 PPP2R2D PPP2R2D PPP2R1A PPP2R1A TGFB2 TGFB2 PIK3CB PIK3CB MAPK10 MAPK10 Pik3r2 Pik3r2 IL1B IL1B AKT2 AKT2 FOS FOS CXCL8 CXCL8 SMAD2 SMAD2 I3M4W8_ICTTR I3M4W8_ICTTR IL12B IL12B IKBKB IKBKB IL10 IL10 TRAF6 TRAF6 NFKBIA NFKBIA Faslg Faslg Gnao1 Gnao1 GNA14 GNA14 GNAI3 GNAI3 ADCY1 ADCY1 CALR CALR ACE ACE LOC101962660 LOC101962660 TGFB1 TGFB1 TNFRSF1A TNFRSF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (520 aa)
NFKB1Nuclear factor kappa B subunit 1. (985 aa)
GNALG protein subunit alpha L. (378 aa)
MAPK1Mitogen-activated protein kinase. (331 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (173 aa)
MAPK12Mitogen-activated protein kinase. (325 aa)
MAPK11Mitogen-activated protein kinase. (325 aa)
CCL5C-C motif chemokine ligand 5. (91 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
GNAI2G protein subunit alpha i2. (355 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (769 aa)
LOC101965906Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (970 aa)
GNAQG protein subunit alpha q. (313 aa)
I3MVL6_ICTTRUncharacterized protein. (192 aa)
CD3DCD3d molecule. (170 aa)
C1QBComplement C1q B chain. (246 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1070 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
IFNGR1Interferon gamma receptor 1. (476 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (840 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
I3N090_ICTTRUncharacterized protein. (207 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (360 aa)
LOC101960206Uncharacterized protein. (207 aa)
KNG1Kininogen 1. (651 aa)
LOC101960961Calreticulin. (437 aa)
CD247CD247 molecule. (144 aa)
LOC101968765Uncharacterized protein. (187 aa)
GNA11G protein subunit alpha 11. (359 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (480 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
LOC101969207C-C motif chemokine. (136 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GNA15G protein subunit alpha 15. (325 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC101968434Angiotensin-converting enzyme. (729 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
LOC101961439TIR domain-containing protein. (1051 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
LOC101968118Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (932 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (488 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (715 aa)
C1QCComplement C1q C chain. (245 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (658 aa)
GnasUncharacterized protein. (244 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (492 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1182 aa)
LOC101967288Uncharacterized protein. (848 aa)
Ppp2cbSerine/threonine-protein phosphatase. (274 aa)
ENSSTOP00000027631SER_THR_PHOSPHATASE domain-containing protein. (235 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
Pik3r3Uncharacterized protein. (461 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (451 aa)
Pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1045 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (509 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1255 aa)
C1QAComplement C1q A chain. (240 aa)
ENSSTOP00000032383Uncharacterized protein. (131 aa)
LOC101967545C-C motif chemokine. (93 aa)
IFNGR2Interferon gamma receptor 2. (306 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (402 aa)
MAPK3Mitogen-activated protein kinase. (361 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (204 aa)
Irak4Interleukin 1 receptor associated kinase 4. (457 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
LOC101968303C-C motif chemokine. (93 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GNAI1G protein subunit alpha i1. (354 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (439 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
MAPK10Mitogen-activated protein kinase. (492 aa)
Pik3r2Uncharacterized protein. (724 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (200 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (467 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
I3M4W8_ICTTRUncharacterized protein. (207 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (327 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
IL10Interleukin 10. (178 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (530 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
FaslgTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (69 aa)
Gnao1G protein subunit alpha o1. (344 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAI3G protein subunit alpha i3. (354 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
CALRCalreticulin. (418 aa)
ACEAngiotensin-converting enzyme. (1309 aa)
LOC101962660Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (824 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
TNFRSF1ATNF receptor superfamily member 1A. (437 aa)
Your Current Organism:
Ictidomys tridecemlineatus
NCBI taxonomy Id: 43179
Other names: Citellus tridecemlineatus, I. tridecemlineatus, Spermophilus tridecemlineatus, thirteen-lined ground squirrel
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